Endocrine Abstracts

Introduction: Turner syndrome (TS) is a chromosomal aberration with a total or partial loss of one of the two X chromosomes, occurring in 1/2000–1/2500 newborn girls. Primary ovarian insufficiency is a classic feature of this syndrome. Therefore, fertility preservation is proposed to girls or adolescents with TS. So far, no pregnancy has been reported in TS women after ovarian or oocyte freezing. The aim of our study was to evaluate the prevalence and the outcome of spont...

Introduction: Clinical features of severe headache, vision loss, and papilledema; normal neuroimaging and elevated opening pressure on lumbar puncture are diagnostic of idiopathic intracranial hypertensions (IIH) or pseudotumor cerebri. Etiology is often attributed to obesity in young female patients. We present a rare case of Pseudotumor cerebri in a non-obese female patient with severe hypocalcemia.Case: A 26 year old Hispanic female patient with past ...

Purpose: To determine the risk of developing hypopituitarism after cranial irradiation for skull base meningiomas. Cranial irradiation is often chosen as first treatment in skull base meningiomas to avoid risk to proximally-located critical structures. While cranial irradiation has been associated with high risk of inducing hypopituitarism, few studies concern meningiomas.Methods and materials: Fifty-two adult patients receiving photon-beam therapyfor sk...

Abundant evidence indicates that the three deiodinases (D1, D2 and D3) function at the pre-receptor level to influence both extracellular and intracellular thyroid hormone levels and hence thyroid hormone action. Indirect evidence supports the concept that a major function of the D1 is to generate T3 for export to plasma whereas the D2 generates T3 primarily for local use. To obtain direct evidence concerning their individual physiological roles we have g...

Polycystic ovary syndrome (PCOS) affects 5–10% of reproductive-aged women and is associated with hyperandrogenism and chronic anovulation. Leukocytes, together with granulosa cells, may contribute to the pathogenesis of PCOS via their ability to secrete an array of cytokines implicated in follicle growth.Aim: Using RT-PCR, we screened for the expression of a range of cytokines in ovarian biopsies obtained from PCOS patients and normal individuals to...

Background: Rathke’s cleft cysts (RCC) are benign intrasellar cysts that originate from the remnants of Rathke’s pouch and contain mucoid material. Most are asymptomatic, but some may compress adjacent structures leading to visual disturbances and endocrinopathies.Case Report: A 20-year-old gentleman had an MRI Head in view of headaches. This showed a 17.7 mm peripherally enhancing suprasellar lesion with no intrinsic T1 high signal pre- contra...

Objectives: The majority of patients with differentiated thyroid carcinoma (TC) have an excellent prognosis, with a 5-year survival rate of 98.3%, and only rarely reaches an advanced stage of disease. The present study aims to identify the clinicopathological and epidemiological features at the time of diagnosis of a group of patients who required to be treated with systemic therapy with tyrosine-kinase inhibitors (TKI).Methods: We retrospectively evalua...

Background and Aim: American Thyroid Association (ATA) guidelines do not consider age at diagnosis of differentiated thyroid cancer (DTC) as a prognostic factor in the estimation of risk of recurrence and persistent disease. While age at diagnosis has already been assessed in high-risk patients, it remains to be established whether there is a correlation between age at diagnosis and long term outcome in DTC patients.Methods: We retrospectively evaluated ...

Background: CV-PTC is often indolent with excellent long-term response, while TCV-PTC (≥50% of tall cells) have aggressive features and worse clinical behavior. Less is known about the clinical behavior of CV-PTC with tall cells <50% (TC/CV-PTC) that, so far, is considered as low risk tumor.Aim: To evaluate the histological presentation of CV-PTC, TC/CV-PTC, TCV-PTC and their clinical behavior after 6 years of follow up.M...

Introduction: Neurofibromatosis type 1 (NF1) is one of the most frequent genetic dominant syndrom in men with a prevalence of 1 in 2600 to 3000 individuals worldwide. NIH NF1 diagnostic criteria are driven by the most frequent manifestations of the disease (‘café au lait’ macules (CAL), neurofibromas, freckling, optic glioma, Lisch nodules and bone lesions). There are many clinical manifestations of NF1 (neurological, cardiovascular, gastrointestinal, endocrine ...