Endocrine Abstracts

Introduction: Differenziated thyroid carcinomas (DTC), particularly papillary thyroid carcinomas (PTCs), usually have an indolent behavior, howewer 10-20% of the patients develop recurrences, following surgery. There are several histological features associated with more frequent recurrences as the hystopathological variants of PTCs, the presence of vascular invasion or lymph node metastases and the presence of extrathyroidal extension (ETE). Case history: a 56yrs old male pat...

Background: Postpartum depression (PPD) is a common mental health disorder with a major impact on maternal health and wellbeing and offspring development. Thyroperoxidase antibody (TPOAb) positivity is a major risk factor for postpartum thyroiditis and via this link, it is hypothesized that TPOAb positivity is a risk factor for PPD. However, the results of currently available single center studies are heterogeneous and affected by major study limitations.<p class="abstext"...

Introduction: MTC is a rare neuroendocrine tumor arising from thyroid parafollicular cells. After initial treatment, patients should be divided according to their clinical status in cured, biochemical persistence (BIO) and structural persistence (STR) of the disease. Concerning BIO patients less is known about the structural disease appearance rate and the time elapsed between the first evaluation after surgery and the appearance of structural disease.Me...

Objective: The treatment with proton pump inhibitors (PPI; omeprazole, pantoprazole, lansoprazole) used for gastritis, gastric ulcer, etc. could lead to L-thyroxine (L-T4) malabsorption issues, that is induced by the increased gastric pH. Many factors like age, way of assumption (during breakfast or with food), other drugs interferences, drug-kinetics, adherence to therapy, could impair the L-T4 absorption.Methods: The study involved 27 hypothyroid patie...

Aims: Surgery is the only curative treatment for medullary thyroid cancer (MTC) patients and the gold standard practice is still represented by total thyroidectomy and prophylactic central neck compartment lymphnode dissection. As it happened for differentiated thyroid cancer, in the last years some authors proposed less aggressive and extent surgical modality as hemithyroidectomy and ipsilateral neck compartment dissection in unilateral and solitary sporadic MTC cases. Few st...

In late pregnancy the mother must mobilise considerable energy stores to support fetal growth. Failure to appropriately nourish the fetus has significant obstetric consequences – gestational diabetes and fetal growth restriction (FGR). Despite this, relatively little is known about how metabolic responses are stimulated in the mother, and how they may go wrong. We previously found that high levels of the product of an imprinted gene, Delta-like homologue-1 (D...

Introduction: The development of pituitary gland is orchestrated by genetic signals, transcription factors and signaling molecules with a crucial role in cell proliferation and differentiation. Anterior pituitary gland is formed by both granular (secretory) and agranular cells represented mainly by follicular-stellate cells. It is known that these cells form a supporting network around secretory cells and produce many kind of growth factors, but their major function remains un...

A 52-year-old female patient with no previous history of interest, and with no prescribed habitual chronic treatment, was admitted to our hospital to be studied for symptomatic hypoglycemias of one month of evolution. Symptoms consisted of malaise, hunger, tremors and profuse sweating that disappeared with food ingestion. She referred hypoglycemic (up to 40 mg/dl) episodes daily, both in fasting and postprandial periods. She even suffered nocturnal episodes that woke her up. O...

Introduction: An increased Body Mass Index (BMI) has been associated with higher prevalence of many cancers, including differentiated thyroid cancer. However, no data have been reported about potential impact of BMI on aggressiveness of presentation and clinical outcome of medullary thyroid cancer (MTC).Aim: To evaluate the potential influence of BMI on clinical presentation and outcome of MTC.Methods: We reviewed anthropometric an...

Background: Several studies have investigated the effects of GH replacement therapy (GHRT) on thyroid function in children with GH deficiency (GHD) leading to contrasting results. Indeed, GHRT has been reported to affect the peripheral metabolism of thyroid hormones, to alter TSH secretion by pituitary and to unmask secondary hypothyroidism.Objective: To evaluate long-term effects of GHRT on thyroid function in a large cohort of GHD children.<p class...