Endocrine Abstracts

Unilateral forms of primary aldosteronism (PA) should, by inference, have a contralaterally normal and therefore suppressed adrenal zona glomerulosa. However, there is no agreed definition of expected adrenal suppression. We hypothesized two biochemical definitions of adrenal suppression based upon measurements done during adrenal vein sampling. These were then applied to a PA–AVS-outcomes database to determine whether either definition proved useful for interpretation of...

Introduction: Recently, Th17 cells and their cytokines were identified to play an important role in the pathogenesis of thyroid autoimmunity. IL-23, produced by antigen presenting cells, is required for survival and differentiation of Th17 cells, and is known to guide T cells toward the Th17 phenotype. Its serum levels are increased in several autoimmune diseases, including Hashimoto’s thyroiditis (HT), however, the expression level of IL-23 within thyroid tissue assessed...

Objective: In our research we studied changes of gait and balance parameters and falls frequency in obese patients during weight loss.Materials and methods: We examined 37 patients aged 23–69 years (average age 53.6±11.1 years) with BMI ≥35 kg/m2 (average BMI 40.9±9.3 kg/m2). All patients received recommendations to adhere hypocaloric diet and perform physical exercises in order to reduce body weight. We evaluat...

Aim of the study was to estimate the effect of complex with 4 kinesiotherapy methods on body weight loss and carbohydrate metabolism in patients with obesity.Material and methods. 80 people were enrolled in the study. 40 people in the first group (G1) -54–63 years old with obesity (mean age 57 [54;63] years, weight 100.5 [89.5;114.8]kg, BMI 35.6 [32.8;43.2] kg/m2, waist circumference WC 105.5 [100.3...

Introduction: Squamous cell carcinoma (SCC) is a very rare thyroid carcinoma with aggressive behavior and poor prognosis. Diagnostic difficulties reside in differentiating SCC from other thyroid malignancies and also in establishing its primary or secondary nature, which are both important for treatment strategy.Case report: A 62-year-old woman, with unremarkable personal and family history, presented in October 2013 with progressive enlargement of a rig...

Background: Approximately 25% of patients with parathyroid carcinoma (PC) have metastases; the most frequent sites include cervical lymph nodes (30%) and lungs (40%). Less common are liver, bones and brain. Surgical resection of local or distant metastases (if possible) provides the best control of hypercalcemia and enhances long-term survival.Case description: A 70-year old patient was admitted to hospital with a primary hyperparathyroidism (PH). He did...

Introduction: Acromegaly impairs the hypothalamic-pituitary-gonadal (HPG) axis and reproductive function that causes amenorrhea and infertility. The mechanism of these disturbances is not clear. Kisspeptin and neurokinin B are very important neuropeptides regulating cyclic LH release from pituitary due to stimulation of GnRH.Aim: The purpose of this study was to assess the role of key reproductive neuropeptides in regulation of menstrual function in pati...

Introduction: Lymphoma of the thyroid gland is an uncommon condition occurring primarily in older women. Most patients have a short history of enlarging thyroid or a neck mass causing tracheal compression. There is also a strong association between thyroid lymphoma and Hashimoto’s thyroiditis. The diagnosis is established by biopsy. The conventional approach to treatment is combination of radiation therapy with multi-agent chemotherapy, while there is no significant role ...

Objective: To study the spectrum of chromosomal anomalies in three cases as related to the phenotypic variability of patients with anomalies of disorder of sexual development.Female 18 years old with secondary amenorrhea, stigmata of Turner’s syndrome, Tanner stage II. Ultrasound showed streak gonads. Hormonal analysis revealed elevated levels of FSH, LH and a low plasma estradiol level. The chromosomal investigation showed gonosomal mosaicism 45,X(...

Aim of the study was to estimate the effect of complex 3-week treatment with 4 kinesiotherapy methods on body weight loss and muscle function in patients with obesity.Material and methods: 80 men and women aged 21-69 years old with alimentary obesity were enrolled in the study (mean age 52.4±11 years, weight 111.3±24.5 kg, BMI 40.3±8.1 kg/m2, waist circumstance WC 113.4±16 cm, hip circumstance HC 124.2±16 cm). The comp...