Endocrine Abstracts

25–30% of normotensive people have salt-sensitive blood pressure, which is an independent risk factor for cardiovascular mortality. The underlying mechanisms are not clear but impaired renal salt excretion and vascular (endothelial) dysfunction are currently viewed as important processes for salt-sensitivity.To add complexity, non-modulation of the hierarchical control systems that regulate renal and vascular function are critical to the development...

Introduction: Presentation of pituitary tumours can be variable.If is a functioning pituitary tumour the clinical manifestation will be that of excessive hormone secreted, and if is a non functioning pituitary tumour, the presentation will be that of target endocrine organ insufficiency.Bradycardia/complete heart block may be a non specific presentation of non functioning pituitary tumours.Cas...

25–30% of normotensive people have salt-sensitive blood pressure, which is an independent risk factor for cardiovascular mortality. The underlying mechanisms are not clear but impaired renal salt excretion and vascular (endothelial) dysfunction are currently viewed as important processes for salt-sensitivity.To add complexity, non-modulation of the hierarchical control systems that regulate renal and vascular function are critical to the development...

Introduction: Presentation of pituitary tumours can be variable.If is a functioning pituitary tumour the clinical manifestation will be that of excessive hormone secreted, and if is a non functioning pituitary tumour, the presentation will be that of target endocrine organ insufficiency.Bradycardia/complete heart block may be a non specific presentation of non functioning pituitary tumours.Cas...

Obesity is a leading global health concern. The gut-brain axis is critical to appetite regulation. The vagus nerve represents the major neural pathway between the gastrointestinal tract and the central nervous system, capable of rapidly communicating information about the nutrient content from different regions of the gastrointestinal tract, directly via nutrient receptors expressed on vagal afferents and indirectly by responding to gut hormones and enteric nervous system sign...

Von Hippel-Lindau (VHL) syndrome is a pathological condition that causes various clinical symptoms and is difficult to diagnose. The most common pathological lesions are hemangioblastomas of the central nervous system, retinal angiomas, renal clear cell carcinomas, and pheochromocytomas. Here we reposrt a case of likely to be VHL due to his family history.Case: A 33-year-old male suffering from hypertension and a history of hemangioblastoma operated in 2...

Introduction: Non-Hodgkin lymphoma (NHL) involving the hypothalamus and pituitary gland is rare. Central nervous system involvement by NHL may be either as a primary tumour or from systemic lymphoma. We report an interesting case of aggressive central nervous system (CNS) lymphoma presenting as pituitary macroadenoma.Case report: A 67-year-old Caucasian woman presented with sudden onset of left eye ptosis and diplopia. Examination showed left third nerve...

Background: X-linked adrenoleukodystrophy (ALD) is a peroxisomal disorder of beta-oxidation that results in accumulation of very long chain fatty acids (VLCFAs) in various tissues. The clinical phenotype of X-ALD in adults is variable and involves adrenal, gonadal and nervous system dysfunction (adrenomyeloneuropathy, AMN). Patients with AMN typically develop spastic paraparesis due to progressive degeneration of the cerebral white matter.Objective: To r...

Brown adipose tissue presently attracts broad interest due to the possibility that it may have the potential to counteract development of obesity and may have other positive metabolic effects, e.g. on glucose and lipid handling. As brown adipose tissue is found, to different extent, in nearly all humans up to middle age, the possibility to affect its activity may be of significance for human health. Brown adipose tissue is affected by several (neuro)endocrine factors. Best stu...

Perinatal action of estrogens or aromatizable steroids at the central nervous system level is responsible for brain development. 4-tert-octylphenol (OP) is knows as an endocrine disrupting chemical (EDC) that is widespread estrogenic chemical used in the costumer produces. Thus, we hypothesis that through early contact with the central nervous system, OP could alter the processes affecting behavior. In this study, primary cortical neurons were exposure to OP (10–6</...