Endocrine Abstracts

Objective: To determine the prevalence and analyze the predictive value of erectile dysfunction (ED) in the occurrence of fictional disorders (MD) in men with diabetes mellitus (DM).Patients and Methods: Cross-sectional study of 90 men presenting with DM. A comparative analysis was performed between two subgroups: G1 (n=75) with MD vs G2 (n=15) without MD.Results: G1 patients were older than G2 (59.7±10.3 vs 58...

Introduction: Stiff-Person Syndrome (SPS) is a rare autoimmune neurological disorder that can be associated with other autoimmune diseases including type 1 diabetes mellitus (T1DM). The presence of alternative forms of autoimmune diabetes, such as latent autoimmune diabetes in adults (LADA) in SPS, is not well described.Case Report: A 63 years old male patient, his medical and family histories were non-specific. He developed progressive rigidity in trunc...

Introduction: Paragangliomas are a diverse group of neuroendocrine tumors arising from chromaffin cells within paraganglionic tissues of the autonomic nervous system.The aim of this study is to review our experience in the management of these tumors.Methods: The medical records of 12 patients with 13 paraganliomas was performed in a a single academic hospital over a period of 32 years from 1990 to 2022.Result...

Introduction: Sarcoidosis may affect the central and peripheral nervous systems in 5–16% of patients. In most cases, such involvement occurs within a multi-systemic disease. Neurological involvement is rare but a potentially life-threatening form of sarcoidosis. The endocrine manifestations of neurosarcoidosis include hypothalamic dysfunction, diabetes insipidus, hypopituitarism, and amenorrhea–galactorrhea syndrome. Herein, we report the case of a patient with hypop...

Case Summary: A 53-year-old lady who was normally fit and well, presented with a 3 months history of polydipsia and excessive polyuria up to 13 litres a day. A water deprivation test confirmed a cranial diabetes insipidus, and she was started on desmopressin. Apart from hypothyroidism that was well controlled with levothyroxine replacement, the rest of her pituitary profile was unremarkable for a lady of her age. The rest of her investigations showed persistent increased infla...

Background: Paragangliomas are rare neuroendocrine tumours arising in the autonomic nervous system, which can secrete excess catecholamines, causing cardiovascular complications. Malignancy occurs in up to 23% of paragangliomas, resulting in a poor prognosis with a 5-year mortality of 43–63%. There’s a limited evidence base for their treatment, with no official guidelines. Peptide Receptor Radionuclide Therapy (PRRT) is a proven treatment for neuroendocrine tumours o...

Thyroid hormone plays a critical role in the production and maintenance of myelin, the lipid-rich sheath that surrounds the outer surface of axons. Myelin is made from processes that extend from oligodendrocytes (OL), a glia cell that comprises about 20% of the cells in the adult central nervous system (CNS). Mature, myelinating OL are produced from a differentiation pathway that begins with neural stem cells and involves the differentiation of oligodendrocyte progenitor cells...

Mitochondrial disorders are the result of mitochondrial respiratory chain dysfunction and caused by mutations of genes encoded by the nuclear or the mitochondrial DNA. They affect approximately 1 in 5000 of the population and are the most common group of inborn errors of metabolism. Most of them involve multiple organ systems with predominant central nervous system features including ptosis, external ophthalmoplegia and sensorineural hearing loss.Introdu...

Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors derived from chromaffin cells of the adrenal medulla and paraganglia of the autonomic nervous system, respectively. Despite a common origin, these tumors are quite heterogeneous in terms of driver mutations, copy number alterations and activated downstream-signaling pathways. Genome wide expression analysis has identified at least three main tumor clusters: a pseudo-hypoxic cluster, one with activation ...

Background: The differential diagnosis of retroperitoneal tumors includes lymphoid, germ cell and neurogenic tumors such as paraganglioma. Paragangliomas are rare neuroendocrine tumors of the autonomic nervous system, which may secrete catecholamines and their metabolites. Clinical features include sustained or paroxysmal hypertension, headaches, sweating and palpitations. Here we present an unusual case of a retroperitoneal tumor entrapping a sympathetic nerve ganglion and mi...