Endocrine Abstracts

Introduction: Since DI was reported to be associated to increase mortality, the aim of this study is to evaluate the presence of autonomic dysfunction (AD) in patients with DI.Methods: We enrolled 12 patients (six females) with central idiopathic DI and 12 controls, matched for age, sex and common cardiovascular risk factors, who were evaluated using the tilt, lying-to-standing, hand grip, deep breath, Valsalva maneuver and Stroop tests.<p class="abs...

Introduction: The endocrine system is often affected in the course of HIV infection. However, hypopituitarism and diabetes insipidus are uncommon disorders in these patients and have been related to drugs, infections of the central nervous system and neoplastic infiltration, in extremely rare cases.Case report: We present a case of a 42-year-old man with HIV infection known since 2005, but undergoing antiretroviral therapy only since 2010 (emtricitabine/...

Introduction: Optimization of iodine intake aims to prevent the irreversible damage that iodine deficiency (ID) can cause in the central nervous system during its development, as well as thyroid disorders that can be induced by both ID and excessive micronutrient intake. The Spanish legal regulation stipulates that iodized salt (IS) must contain 60 mg of iodine per kg of salt (60 ppm), allowing a tolerance of ±15%. The aim of this study is to address the iodine content of...

Introduction: Hypothyroidism can affect the nervous system, commonly causing mono and polyneuropathies which show a variable frequency and pattern. Its mechanisms are not fully understood. Symptoms usually correlate better with the duration of the dysfunction rather than with its severity and typically improve significantly after medical therapy.Case report: A 58-year-old woman was admitted at our hospital with a one-year history of progressive weakness ...

Fifty-five years old patient with background of type 2 DM, referred by the GP with low serum Cortisol levels (<50), when was investigated for his ongoing symptoms of tiredness with low energy level. He also noticed reduced sexual drive and erectile dysfunction worsening over years along with reduced shaving frequency, to twice a week and sparse hair growth on his body. He denied any trouble with his peripheral vision or any significant headaches, but did feel dizzy on occa...

The endocrine cells of the gastrointestinal system are scattered amongst the mucosal cells and respond to luminal influences via projecting microvilli. They also respond to a rich neural supply through the submucous plexus. These two influences, luminal nutriments and local innervation, compete with control by circulating hormones and also nutriment concentrations. The gut endocrine cells are widely scattered down the mucosa (diffuse endocrine system) and their response is pro...

Background: Management of patients with CAH remains challenging. There is increasing evidence to suggest that failure to optimize treatment during childhood not only affects final height but also leads to psychological and psychiatric problems. Previous qualitative structural T2-weighted MRI studies have identified white matter hyper-intensities in up to 46% of CAH patients. The nature and functional relevance of these abnormalities remains unknown.Objec...

Background: Craniopharyngioma is a rare epithelial tumor of the central nervous system, affecting both children and adults and associated with significant morbidity.Objective: To study the potential differences in the clinical and radiological presentation of craniopharyngioma in children versus adults in a large mixed cohort.Material and methods: We performed a retrospective review of craniopharyngioma patients evaluated in the Na...

Introduction: Primary amenorrhea is defined as the absence of menses at age 15 years in the presence of normal growth and secondary sexual characteristics, or at 13 years, if there is no breast development. We retrospectively assessed the causes of primary amenorrhea in a series from an academic center of adult endocrinology.Patients and methods: We retrieved data from the files of 111 consecutive patients with primary amenorrhea evaluated in our center ...

Adrenoleukodystrophy (ALD) is an X-linked, widely heterogeneous, neurodegenerative disorder of peroxisomal metabolism characterised by the accumulation of very-long-chain fatty acids (VLCFA). A mutation in the ABCD1 gene is responsible. ALD has both a neurological and an endocrine interface as VLCFA deposit in the central and peripheral nervous system as well as the adrenal cortex and testis. ALD can present in childhood with a cerebral form or later in life as an adrenomyelon...