Endocrine Abstracts

Morvan’s syndrome is a rare autoimmune disease characterised by peripheral nerve hyper excitability, central nervous system symptoms and autonomic dysfunction which can mimic other endocrine presentations with symptoms including hyperhidrosis, weight loss, neuromyotonia and insomnia. Morvan’s is associated with malignancy, in particular thymomas, suggesting a paraneoplastic aetiology. This case is the first to associate Morvan’s with renal carcinoma and proposes...

Background: Type 2 DM and chronic renal disease CKD are conditions associated with severe hypertension, loss of the blood pressure circadian rhythm (CR) and sympathetic nervous system (SNS) hyperactivity, suggesting a deficient dopaminergic modulation that could be reversed with dopamine agonists such as bromocriptine (BEC).Objective: The objective of this study was to evaluate the effect of bromocriptine in the blood pressure CR in patients with type 2 ...

Background: C-peptide therapy ameliorates sensory nerve function in T1DM neuropathy. Prolonged GLUT-4 translocation and delayed counter regulation can induce hypoglycemia. GLUT-2 protein is the primary hepatic liver transporter related to hepatic glucose regulation it also plays a role on glucose sensing by pancreatic beta cells, via hepatoportal sensors controlling the autonomic nervous system and stimulates glucagon secretion.Objective: To discuss the ...

Introduction: Interleukin (IL)-6 can activate signal transducer and activator of transcription (STAT)3-dependent signaling similar to leptin in neurons. Here we demonstrate that central application of IL-6 suppresses feeding and improves glucose tolerance in mice. Furthermore, we found that central IL-6 trans-signaling is enhanced in obese mice to improve anorexigenic and glucoregulatory effects of IL-6.Methods/design: Glucose tolerance and insulin sensi...

Abstract: Inflammation plays a contributing role in the pathogenesis of several metabolic disorders, including type 2 diabetes and obesity. Intriguingly, obesogenic diets induce markers of hypothalamic inflammation and neuronal injury in both rodents and humans, suggesting that targeting inflammatory pathways in the hypothalamus might represent a novel strategy to control energy metabolism. Unfortunately, the majority of steroid-based anti-inflammatory drugs are fraught with a...

Introduction: PATRO adults is an international, longitudinal, non-interventional study of the long-term safety and efficacy of recombinant human growth hormone (rhGH; Omnitrope®, Sandoz). The study will provide additional data on the long-term safety of rhGH in adult patients with severe GH deficiency (GHD). Here, we present safety data from an interim analysis.Methods: Eligible patients are adults who are receiving treatment with Omnitro...

Introduction: Since 2012, different heterozygous mutations in the THRA gene have been described in patients with resistance to thyroid hormone alpha (RTHα). The associating symptoms are reminiscent of untreated congenital hypothyroidism (growth retardation, psycho-neuromotor disorders, delayed bone development and bradycardia) but with raised T3/T4 ratio and normal TSH levels. All genetic abnormalities act in a dominant negative (DN) manner against functional rec...

Postural orthostatic tachycardia syndrome (PoTS) occurs as a consequence of the abnormal functioning of the autonomic nervous system (dysautonomia). Despite the many associated conditions, the assessment and relationship to reactive hypoglycaemia has not been explored in the clinical literature.The purpose of this retrospective observational-cohort study was to identify relationships between the physical and biochemical characteristics in potential carbo...

Introduction: Adrenomyeloneuropathy (AMN) is a form of X-linked adrenoleukodystrophy (X-ALD) a rare inherited disorder (estimated prevalence 1:20 000 to 1:50 000) characterized by the accumulation of very long chain fatty acids (VLCFA) and affects mainly the nervous system white matter and the adrenal cortex and nearly 100% penetrance in males. Widely varying phenotypes and prognoses often co-occur in a single kindred.Methods: We report a case diagnosed ...

Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder most commonly characterized by osteolytic bone lesions. Central nervous system (CNS) involvement observed at 6% and Diabetes insipidus (DI) one of the important signs of CNS involvement.A 40-years-old woman presented with polyuria, polydipsia and headache. Water deprivation test was compatible with DI. Magnetic resonance imaging (MRI) shows 4×4 mm focal thickening at the distal infun...