Endocrine Abstracts

In most countries in the world, an increasing number of people suffer from the metabolic syndrome, normally defined as obesity, high blood sugar, high blood fats and high blood pressure. The new understanding that adult humans possess active brown adipose tissue has led to hope that a (re)activation of this tissue (browning) may be helpful in ameliorating the metabolic syndrome. Brown adipose tissue has the ability to combust (extra) food intake in a direct way, due to the uni...

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of reproductive age women and is characterized by reproductive, metabolic and psychological features exacerbated by weight gain. Weight management in PCOS is challenged by propensity to weight gain and lack of sustainable dietary interventions. Body weight is regulated by calorie intake and the rate of energy expenditure. Metabolically active brown adipose tissue (BAT), contributing to energy dissipation, has b...

Background: Long-term safety data (1998 to mid-2016) are reported for adult patients with GHD treated with GH (Norditropin® (somatropin), Novo Nordisk) as prescribed by treating physicians in the real-life clinical setting and enrolled in NordiNet® International Outcome Study (IOS) (NCT00960128), a non-interventional, multicentre study.Objective and hypotheses: To describe and report safety data and incidence rates (IRs) (...

Introduction: Von Hippel–Lindau syndrome (VHL) is an autosomal dominantly inherited neoplastic disorder with marked phenotypic variability, characterized by a broad spectrum of clinical manifestations in central nervous system (CNS) and viscera. Specific gene mutation can be demonstrated; however imaging plays an important role in diagnosis. 68Ga-labelled somatostatin analog (68Ga-DOTANOC) PET-CT is routinely employed for somatostatin receptor (SSTR) imaging, mainly for n...

Introduction: Woodhouse-Sakati Syndrome (WSS) is a very rare autossomic recessive disorder caused by mutations in DCAF17 gene that primarily affects the endocrine and the nervous systems. It is associated with hypogonadism, diabetes mellitus, hypothyroidism, sensorineural hearing loss, alopecia and extrapyramidal findings. Treatment is symptomatic and managed by multidisciplinary teams. Less than 80 cases are reported to date.Case repor...

Objective: To determine the hypoglycaemia prevalence in an old-patient hospitalized and to stablish the factors associated with its appearance and to study the association between the hypoglycaemia with the stay in hospital and the mortality during the hospitalization.Material and method: A retrospective study in which all patients, older than 65 years old that were hospitalized during 2014 and at least two glycemic control have been realised, were inclu...

Introduction: Langerhans cell histiocytosis (LCH) is a very rare disease in adults and as well a very rare cause of sellar expansion. The clinical presentation can be heterogeneous, from a single bone lesion to potentially fatal, widespread disease. We describe the difficulties with the evaluation and the treatment of LCH.Case: 39 years old woman has had amenorrhea for 2 years and higher intake of fluids (5–7 l/day) for 6 years. Non-functioning pitu...

Background: Craniopharyngioma is a rare epithelial tumor of the central nervous system, affecting both children and adults and associated with significant morbidity.Objective: To study the posttreatment evolution of craniopharyngioma in children and adults in a large mixed cohort.Material and Methods: We performed a retrospective review of craniopharyngioma patients evaluated in the National Institute of Endocrinology in Bucharest ...

Introduction: The ongoing, international, open, longitudinal, non-interventional study, PATRO Adults, aims to determine the long-term safety and efficacy of Omnitrope® (Sandoz), a recombinant human growth hormone (rhGH). Safety data from an interim analysis are presented here.Methods: Eligible patients are male or female adults who are receiving treatment with Omnitrope® and who have provided informed consent. Patients tre...

Pituitary carcinoma (PC) is defined by the presence of pituitary tumor that is either not contiguous with the primary sellar tumor and/or has metastasized to distant sites. It is very rare and associated with poor prognosis, with a median survival of 12 months when systemic metastases are present, and 30 months when metastases are confined to the central nervous system. A 20 years-old man was first diagnosed with a nonfunctioning pituitary macroadenoma in 1981 and submitted to...