Endocrine Abstracts

The ability of thyroid hormones to regulate body temperature is well established. While the active hormone T3 can act peripherally to induce thermogenesis in fat and muscle, it also acts centrally in the brain to increase body temperature through the sympathetic nervous system. Most remarkably, recent studies show that T3 treatment in mice causes an elevated body temperature even at 10°C, far below thermoneutrality, suggesting that the T3 effect constitutes pyrexia rather...

Introduction: Paragangliomas (PGLs) are tumors originating from neural crest-derived cells situated in the region of the autonomic nervous system ganglia. Head-and-neck PGLs (HNPGLs) originate from the sympathetic and parasympathetic paraganglia, most frequently from the carotid bodies and jugular, tympanic and vagal paraganglia, and are usually non-catecholamine secreting.Case report: We present the case of a 60 years old male patient, which was admitte...

Introduction: Adrenoleukodystrophy (ALD) is a rare, X-linked inherited, genetic disease, characterized by a disorder of peroxisome metabolism, leading to the accumulation of very long-chain fatty acids (VLCFAs) mainly at the central nervous system and the adrenal glands. It usually occurs in childhood, but there are types of the disease that manifest later in life.Case: A 57-year-old man with a history of progressive spastic paresis, starting at the age ...

Introduction: Aniridia is a rare congenital condition which is characterized by a complete or partial absence of the iris and fovea and malformations of the lens and anterior chamber. It is usually related to mutations in PAX6, a member of a multigene family of transcription factors, which is important for the development of the nervous system, the eyes and also the endocrine pancreas and it is found to be associated with mild glucose intolerance. Complete loss of insulin secr...

Introduction: Sulphonylureas (SU) are an effective therapy for type 2 diabetes (T2DM). As insulin secretagogues, hypoglycemia is a potencial adverse effect. Hypoglycemia may cause neuroglycopenic brain injury, which can mimetize stroke and infections of the central nervous system. Case ReportThe authors report the case of an autonomous 71 year-old woman, with medical history of hypertension and T2DM, treated with enalapril and gliclazide, that was admitted in the Emergency Roo...

Introduction: Adrenocortical carcinoma (AC) is a rare malignant endocrine tumor of the adrenal cortex. The psychiatric manifestations observed in AC are associated with a delayed diagnosis.Case presentation: A 27-year-old women with medical history of severe psychosis resistant to antipsychotic medications, was hospitalized in our unit for Cushing’s syndrome (CS). The physical examination revealed classical signs of CS. The Laboratory results showed...

Introduction: Pituitary adenoma and meningioma are the most benign tumors in the central nervous system (meningioma 35,9%, pituitary tumor: 15,5%). Pituitary adenoma associated with meningioma without a history of radiotherapy is extremely rare.Case: A 70 years old man operated for post-traumatic subdural hematoma in whom the brain MRI (magnetic resonance imaging) had also shown a macroadenoma, completed with an MRI of the sellar region which were confir...

Introduction: Neurofibromatosis type 2 (NF2) is an autosomal dominant genetic disorder that cause a growth of noncancerous tumors in the nervous system, it associates cranial schwannomas, meningiomas, and skin and ophthalmologic lesions. It is a rare condition and its association with an intrasellar arachnoidocele has not been reported yet. We report the case of a patient who presents a NF2 associated with hypopituitarism related to an intrasellar arachnoidocele.<p class="...

Introduction: ACTH-secreting pituitary adenomas occasionally present as aggressive pituitary tumors (APT), with invasion of surrounding structures, rapid growth, resistance to conventional therapies and multiple recurrences. In rare cases they can progress to pituitary carcinomas (PC) in several years, diagnosis being made upon the documentation of systemic or central nervous system (CNS) metastatic spread. Among pituitary carcinomas, the most common malignant subtypes are lac...

Introduction: Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with diverse manifestations. Patients with NF1 are particularly prone to developing tumors of the central nervous system (CNS) and endocrine disorders. Herein we report a case of pituitary hyperplasia in a woman with NF1.Observation: A 55-year-old woman was referred to our department for the exploration of recurrent hypoglycemia. Her past medical history included NF1, asthma t...