Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

Published by BioScientifica

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ea0026p207 | Pituitary | ECE2011

Mechanism of anterior pituitary gene regulation by LHX3 in paediatric combined pituitary hormone deficiency

Malik R , Hunter C , Colvin S , Rhodes S

LHX3, a member of the LIM-homeodomain family of developmental transcription factors, is required for establishment of mammalian anterior pituitary hormone-secreting cell types as well as the formation of specialized neurons of the nervous system. Paediatric patients with pituitary insufficiency are sometimes diagnosed with combined pituitary hormone deficiency disease (CPHD). This disease can be linked to mutations in essential pituitary developmental transcription factor gene...
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ea0016oc1.8 | Neuroendocrinology and pituitary | ECE2008

Differential sensitivity of men and women to anorexigenic and memory improving effects of intranasal insulin

Benedict Christian , Kern Werner , Schultes Bernd , Born Jan , Lehnert Hendrik , Hallschmid Manfred

Background: Central nervous insulin is critically involved in the regulation of body weight and memory processing. Long-term administration of intranasal insulin reduces body weight in men but not in women while improving hippocampus-dependent memory processing in both genders. Here, acute effects of intranasal insulin on food intake and memory functions were studied in men and women.Methods: Thirty-two healthy, normal-weight subjects (14 men, 18 women) ...
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ea0086cps1.3 | Section | SFEBES2022

What talks to brown fat?

Cannon Barbara

The thermogenic activity of brown adipose tissue (BAT) may be a major determinant of energy balance and thus of obesity versus slimness. The acute and chronic regulation of BAT may therefore be a significant issue in body weight control. From a classical aspect where BAT is only controlled by nervous input, we see today a growing array of factors that have been forwarded as being physiologically important regulators. These factors include both classical hormones such as thyroi...
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ea0086p257 | Neuroendocrinology and Pituitary | SFEBES2022

The modulatory role of curcumin and quercetin on Drosophila GSK-3: a potential therapeutic intervention in Parkinson’s disease

Olanrewaju John , Russell Steve

Aim: We explored the mechanistic interactions and potential therapeutic benefits of curcumin and quercetin co-administration with a specific focus on Glycogen synthase kinase 3 GSK-3 activity.Methods: We hypothesize that excess GSK-3 accumulation in the substantia nigra is driven by oxidative stress and aim to test the effects of these compounds on the localization and activity of GSK-3 in the well-established model organism Drosophila melanogaster. We p...
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ea0041s27.3 | Why do we gain weight; homeostasis and rewards of ingestive behaviour | ECE2016

How hypothalamus senses and stimulates food intake

Horvath Tamas L

Emerging evidence indicates that the hypothalamus is a key regulator of the adaptation of the central nervous system (CNS) to the changing environment in support of survival, with subsets of hypothalamic neurons acting as upstream regulators of brain regions classically considered as master determinants of CNS function, such as the cortex and hippocampus. The regulatory role of the hypothalamus in cortical and hippocampal functions is mediated via classical neuronal pathways a...
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ea0040lb20 | The bright and dark side of transthyretin, a thyroxine plasma transporter | ESEBEC2016

L20 – Biography

Maria João Mascarenhas Saraiva received a BSc in Biology from the University of Porto, Portugal, in 1976, and an MSc in Biochemistry from the University of London, in 1978. Between 1980 and 1984, she did a PhD in biochemistry at the University of Porto, and qualified as Professor of Biochemistry in the University of Porto in 1991. She worked for different periods as a Visiting Scientist at the ...
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ea0016p820 | Thyroid | ECE2008

Visual evoked potentials in children with hypothyroidism

Zak Teresa , Noczynska Anna , Klempous Joanna , Pilecki Witold , Szawronowicz Teresa

The clinical picture of hypothyroidism is well described. It is well known that thyroid hormones are very important to development and maturation of the central nervous system. They have influence on the synthesis of proteins and production of enzymes and myelin.Myelin synthesis is an important factor in determining the speed of impulse transmission along complex polysynaptic pathways, such as those mediating the evoked potentials....
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ea0014p539 | (1) | ECE2007

Incorporation and release of 3H-norepinephrine by granulosa cells: Novel functionality for endocrine cells

Greiner Monika , Lara Hernán E

Ovarian function in mammals is regulated by gonadotropins and by sympathetic nervous system. Norepinephrine (NE) is one of the major neurotransmitters present in the fibres innervating the gonad and regulates follicular development and ovarian steroids release. Surgical section of the sympathetic fibres partially decreased the release of NE as compared with non-denervated rats. The remnant release capability supposes the existence of an intraovarian compartment able to incorpo...
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ea0077p175 | Metabolism, Obesity and Diabetes | SFEBES2021

Pressure from pericytes: angiotensin II induced neuropathic pain development as a complication of hypertension

Hardowar Lydia , Sheavyn Matt , McTernan Philip , Bates Dave , Hulse Richard

The renin angiotensin system (RAS) is targeted as means of medical intervention for hypertensive associated complications of stroke, heart failure and obesity. Ultimately, the inhibition of Angiotensin II(ANGII)/Angiotensin II type 1 (AT1) receptor complex has been key in reducing raised blood pressure. Diabetic neuropathic pain (NP) is highly prevalent in the United Kingdom, associated with an increasingly aged population. There is growing acknowledgment that the vascular com...
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ea0077p180 | Metabolism, Obesity and Diabetes | SFEBES2021

Neurotensin improves glucose tolerance via activation of peripheral NTSR1-expressing neurons

Roberts Anna , Norton Mariana , Martin Alonso Aldara , Phuah Phyllis , Cheng Sijing , Smitherman-Cairns Tobias , Hanyaloglu Aylin , Murphy Kevin

Neurotensin is a 13-amino acid peptide expressed in both the brain and the gastrointestinal tract where it acts as a neuropeptide and gut hormone, respectively. Centrally, neurotensin plays a role in appetite, analgesia and thermoregulation, whereas peripheral neurotensin regulates lipid absorption, gastric emptying and exocrine pancreatic secretion. The role of neurotensin in the control of glucose homeostasis currently remains unclear. We found peripheral administration of n...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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