Endocrine Abstracts

De novo lipogenesis (DNL) is recognised as potentially contributory to pathogenesis of non-alcoholic fatty liver disease (NAFLD), and could be a factor in the progression of simple steatosis to steatohepatitis, although it contributes a relatively minor amount of whole body fat compared to dietary lipid. Consequently understanding the lipidome during induced DNL may provide insight into potential biomarkers of DNL that could be clinically relevant in those at risk of ...

Introduction: Iodine may aggravate maternal autoimmune thyroid diseases during and after pregnancy, but selenium could defend against it’s harmful effect. Objective: to study the course and complications of Hashimoto’s thyroiditis in pregnant and lactating women receiving iodine and selenium therapy. Material and method. Serum TSH, free-T4 and anti-thyroid peroxidase-antibody were measured in 30 women with chronic autoimmune thyroiditis in every gestational trimester...

Tuberous sclerosis complex is characterised by non-malignant tumours in the skin, brain, kidneys, heart, eyes, lung, but sometimes angiomyolipomas may develop in the adrenals, ovaries, thyroid, and rarely neuroendocrine tumours in the pancreas, pituitary gland, parathyroids. The case of a 46-years-old female patient suffering of tuberous sclerosis and endocrine disturbances is presented. She is known with temporal lobe epilepsy since early childhood, and anxious depressive dis...

Insulin resistance has a pivotal role in the pathogenesis of polycystic ovarian syndrome (PCOS), thus insulin sensitizer therapy is beneficial. Purpose. Our purpose was to study the effectiveness of metformin in PCOS women, including those without insulin resistance. Matherials and methods. This study was conducted on 24 pacients (12 obese or overweight and 12 lean women), aged 21–31 years, diagnosed and treated with PCOS at the Clinical Department of Endocrinology Targu-...

: Thyroid cancers represent approximately 1% of new cancer diagnoses. Thyroid malignancies are divided into papillary carcinomas (80%), follicular carcinomas (10%), medullary carcinomas (5–10%), anaplastic carcinomas (1–2%) other rare tumours (primary thyroid lymphomas, primary thyroid sarcomas). The main therapeutic options are surgery (mainly total thyreoidectomy), radioiodine treatment (depending on the type and stage of the tumour), levothyroxine therapy (thyroid...

Introduction: In iodine deficient regions maternal iodine supply is indispensable for the normal development of the fetus, but it might aggravate autoimmune thyroid diseases in the mother during pregnancy and postpartum. Selenium might be beneficent in these thyroid diseases by defending against the harmful effect of iodine on maternal thyroiditis.Objective: To study the course of Hashimoto’s thyroiditis in pregnant women, under combined therapy wit...

Introduction: The urinary iodine excretion (UIE) from fasting morning urine sample is a good epidemiologic indicator for iodine state, used in populational groups (schoolchildren, pregnant women) at risk to develop iodine deficiency disorders. It is not adequate to evaluate individual iodine intake. In pregnant women, especially with chronic autoimmune thyroiditis, it is important to estimate iodine state.Objectives: To evaluate the individual iodine sta...

We report the case of a 25-year-old woman (K.Cs.) hospitalized in our clinic for endocrinological investigation, presenting a spontaneous abortion 3 weeks before hospitalization. From medical history, we mention a cerebral thrombophlebitis with intracranian hypertension syndrome, appeared after oral contraceptive drug (Diane 35R) used for 5 months. The clinically asymptomatic patient presented diffuse goiter (I. gr.), overweight and virilism, without other clinical ...

Regular red blood cell transfusions for thalassemia major leads to iron overload in endocrine glands, inducing deficient function of the pituitary, thyroid, parathyroid etc. In thalassemia intermedia these endocrine disturbances may appear due to increased intestinal iron absorption and occasional transfusions, but are less frequent and milder. We have no data about their presence in thalassemia minor.We present the case of a young woman known with mild ...

Objective: To study thyroid microcarcinomas in surgical samples obtained by thyroidectomy.Material and methods: We studied 311 patients thyroidectomized for different thyroid diseases in 2007, histology being made in the Institute of Pathology Tg.Mures.Results: Surgery was made for uni- and multinodular goiter in 278, for Graves-disease in 28, and for other forms of hyperthyro-i-dism in 5 cases. Thyroid cancer was diagnosed in 65 c...