Endocrine Abstracts

Aim: The primary objective of this study was to evaluate the structural and functional cardiac parameters with MRI in patients with primary hyperparathyroidism (pHPT) before and after successful surgery.Method: In this prospective study 16 patients with pHPT were included. Detailed cardiac magnetic resonance imaging (MRI) examinations were performed preoperatively and at six months post-surgery. Following parameters were measured: Left ventricle ejection...

Purpose: Cocaine and amphetamine-regulated transcript (CART) influences the appetite, obesity and pancreatic functions. The aim of this study is to determine the CART level of patients with PCOS and examine the relation with the insulin resistance in patients with PCOS.Methods: 41 patients with PCOS and and 39 healthy women were included in the study whose age and BMI matched. For PCOS diagnosis, 2003 Rotterdam criteria were used. The fasting serum gluco...

Introduction: Lipocalin-2 is abundantly expressed in mature adipocytes and causes insulin resistance. In the physiopathology of PCOS, insulin resistance has great importance. The purpose of this study was to determine serum lipocalin-2 levels in patients with PCOS and to investigate its relationship with body fat percentage, hs-CRP and insulin resistance.Methods and designs: This study was planned as a case controlled study. We enrolled 44 women with PCO...

Graves’ disease (GD) is an autoimmune disease caused by autoantibodies binding to and activating the thyroid-stimulating hormone receptor (TSHR). Chronic stimulation of the TSHR results in a hyperactive thyroid gland and hyperthyroidism. The purpose of this study was to determine the association between Rho-kinase (ROCK1 and ROCK2) gene polymorphisms and GD in a Turkish population. A total of 142 patients with HT and 163 healthy control subjects were in...

Graves’ disease (GD) is an organ-specific autoimmune disorder of the thyroid due to the presence of circulating anti-thyroid-stimulating-hormone receptor stimulating autoantibodies that lead to hyperthyroidism. Involvement of the genetic variants of RHO genes in GD has not been examined yet. Therefore, the aim of this study was to investigate possible associations between RHO gene polymorphisms and GD in a Turkish population. A total of 128 patients with GD and ...

Introduction: Although pericardial effusion is a common finding in primary hypothyroidism, massive pericardial effusion or pericardial tamponade are rare. Herein, we describe a newly diagnosed case of primary hypothyroidism initially presenting with massive pericardial effusion.Case report: A 64 years old male patient attended to the emergency unit with worsening dyspnea over the past 1 month. ECG showed a low voltage QRS wave. Chest X-ray showed increas...

Introduction: It is well known association between cardiovascular disease and PCOS. Approximately 17–43% of women with PCOS have hyperprolactinemia. Increased levels of prolactin often associated with an increased risk for thromboembolic events, but underline pathophisiological mechanism still unknown. The strong association between hyperprolactinemia and platelet aggregation is well known. Platelets play a key role in the development of atherothrombosis, a major contribu...

Introduction: Ectopic adrenocorticotropic hormone (ACTH) syndrome is characterized by hypercortisolism due to the hypersecretion of non-pituitary ACTH-secreting tumor leads to the Cushing’s syndrome. Herein, we present a case with Cushing’s syndrome, which is diagnosed ACTH-secreting renal malignant paraganglioma.Case: A 40-year-old woman presented with a 5 month history of newly diagnosed hypertension and diabetes, weakness, hyperpigmentation,...

Introduction: Common polymorphisms of the fat mass and obesity associated gene (FTO) is known to associate with increased obesity and diabetes mellitus type 2. This was the first study to investigate the association between the rs9939609 FTO gene polymorphism and gestational diabetes mellitus (GDM) in Turkish women.Patients and methods: The case-control study included 203 gestational diabetes and 191 non-diabetic pregnant controls. Anthropometric and bio...

Purpose: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive period, and it has been considered as a risk factor in cardiovascular disease due to increased prevalence of hypertension, dyslipidaemia, obesity, and insulin resistance. Platelets have a pivotal role in the development of atherothrombosis. Platelet distribution width (PDW) is a marker of platelet size that reflects the heterogeneity of the platelets. This arithmetical inde...