Endocrine Abstracts

Background: Obesity is worldwide epidemics and the main risk factor for many diseases. Traditional methods of prevention and treatment of obesity often unfavorable and patients undergo to alternative treatment such as bariatric surgery. To better understanding the pathogenesis of obesity, we aimed to analyse the main abnormalities in blood serum in patients accepted to bariatric surgery.Material and Methods: 27 patients (13 men and 14 women) with obesity...

Background: Increasing of the level of circulating Antithyroid autoantibodies suggested about autoimmune destruction in thyroid gland and not always depends from thyroid status. We aimed to study the frequency of circulating antithyroid autoantibodies (ATAB) in people with the different thyroid diseases.Material and Methods: In 25 people with high level of circulating ATAB blood serum TSH, T3, T4, glucose, ALAT, protein, albumin levels were measured. Thy...

IntroductionNaKATPase is membrane bound enzyme, necessary for maintenance of the cell potential and volume, ion flow, neuronal signal transduction. Previous studies showed decreasing of its activity in patients with diabetes mellitus (DM). Mechanisms regulated enzymes activity in DM is not clear yet. We proposed that glycemia is a main regulator of NaKATPase activity in erythrocytes at the DM.Material and methods<p class="abste...

IntroductionProblems with thyroid cancer and its diagnosis are one of the current issues in modern endocrinology. Ultrasound examination detects thyroid nodules in 19-67%of the population, whereas the new classification of thyroid ultrasound examination proposed by the American Association of Thyroidologists – the use of TI-RADS in the diagnosis of thyroid cancer increases the diagnostic accuracy of this test by 91–95%. The aim of our study was...

Polycystic ovary syndrome (PCOS) is a highly prevalent and representing the most common endocrine-metabolic disorder in reproductive-aged women. PCOS ishighly correlated with insulin resistance and hyperandrogenism. Myo-inositol (MI) supplementation in women with PCOS has been evaluated over the last years. Many hormonal and reproductive impairments associated with this disorder seem relieved by the supplement.Material and Methods: The meta-analysis was ...

Introduction: In hypothyroidism bone turnover and osteoclastic resorption will be reduced which also aggravates Rheumatoid arthritis (RA) symptoms. In the literature shown data about relationship between RA and thyroid dysfunction. We aimed to discuss some possible causes and triggers that interplay in both conditions based on data from the literature.Material and methods: Data analysis was done using the systematic search performed in PubMed, MEDLINE, S...

Introduction: Thyroid surgery usually performed in 20% when traditional drug therapy was not effective, or development severe complications, or high risk/presence of cancer. New infection COVID19 affected whole body and probably thyroid results changes in clinical future and treatment. The aim of our study were investigate if frequency and type of thyroid surgery affected by COVID19 pandemics. Material and methods: We analysed and compared data from one ...

Introduction: Neurodegeneration is one of the most common condition accompanied Diabetes Mellitus, Parkinson’s and Alzheimer’s diseases. Although its mechanisms intensively studied for many years, some questions of pathogenesis remain unclear. The aim of the study was investigate the effects of thyroid hormones and some neurotransmitters on the cerebral cortex of rats with experimental neurodegeneration. Materials and methods: Series of experim...

Introduction: As were previously shown the erythrocytes glucose uptake is impaired in patients with the Diabetes Mellitus, obesity and polycystic ovarian syndrome due to insulin resistance. For further, study whether the erythrocytes glucose uptake will be impaired in rats with experimental metabolic syndrome were observed gradually.Material and methods: The 40 adult white male rats separated into 4 groups. In 10 rats diabetes were induced by injection o...

Background: People with type 2 Diabetes Mellitus (DM2) more predisposed to Non-Alcoholic Fatty Liver Disease (NAFLD). Accompanied chronic pancreatitis impaired glycemic control by affecting gastrointestinal absorption, also by affecting of pancreatic insulin secretion. We study the frequency of NAFLD in DM2 patients with accompanied chronic pancreatitis.Material and Methods: In 44 people with DM2 blood glucose, HbA1c, Cholesterol, triglycerides, LDLP, HD...