Searchable abstracts of presentations at key conferences in endocrinology

ea0032p234 | Clinical case reports – Pituitary/Adrenal | ECE2013

Combined choroidal neovascularization and hypopituitarism in a patient with homozygous mutation in methylenetetrahydrofolate reductase gene

Aydogdu Aydogan , Haymana Cem , Baskoy Kamil , Durukan Ali Hakan , Ozgur Gokhan , Azal Omer

Introduction: Hypopituitarism is defined as either partial or complete deficiency of anterior or posterior pituitary hormone secretion or both. Hypopituitarism itself may increase the risk of thromboembolism/hypercoagulopathy, and underlying mechanisms of hemostatic dysfunctions in hypopituitarism are mostly unknown. Reduced enzymatic activity due to methylenetetrahydrofolate reductase (MTHFR) gene mutations are associated with hyperhomocysteinemia and have been linked to both...

ea0022p148 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Searching for the metabolic syndrome criteria in young adults with hypogonadism

Sonmez Alper , Haymana Cem , Bolu Erol , Tapan Serkan , Barcin Cem , Aydogdu Aydogan , Taslipinar Abdullah , Kutlu Mustafa

Introduction: The evidence shows that the prevalence of metabolic syndrome is increased in patients with hypogonadism. However, much of the data regarding this association comes from the elderly patients with obesity, hypertension or type 2 diabetes. The total testosterone levels alter physiologically in these conditions and thus can falsify the association. We aimed to investigate the prevalence of the metabolic syndrome in young adults with hypogonadism who do not have any c...

ea0041ep542 | Diabetes therapy | ECE2016

Add on exenatide treatment in obese type 2 diabetic patients under intensive insulin regiments

Sonmez Alper , Dinc Mustafa , Taslipinar Abdullah , Aydogdu Aydogan , Meric Coskun , Basaran Yalcin , Haymana Cem , Demir Orhan , Azal Omer

Introduction: Intensive insulin treatment in obese patients with type 2 diabetes (T2DM) is often difficult. Insulin dosages are much higher, which further increase weight gain and the risk of hypoglycemia. Glucagon like peptide 1 receptor agonists (GLP-1RAs) are the promising treatment modalities causing weight loss and reducing the risk of hypoglycemia. There is no published data about the effect of adding on GLP1RAs to obese T2DM patients with un-controlled glucose levels un...

ea0056p566 | Obesity | ECE2018

Does follicle stimulating hormone effect adiposity in patients with hypergonadotrophic hypogonadism: a retrospective study

Demirci Ibrahim , Haymana Cem , Gulcelik Nese Ersoz , Sonmez Yusuf Alper , Meric Coskun , Aydogdu Aydogan , Demir Orhan , Azal Omer

Introduction: Recent studies showed that post-menopausal osteoporosis and weight gain starts at the perimenopause stage, a period characterized by relatively stable estrogen and rising FSH levels. FSH is found to be associated with adiposity in women, which is also a great risk factor for type 2 DM. There is also a sharp increase in visceral adiposity during this life stage, which coincides with the emergence of disrupted energy balance and reduced physical activity. There is ...

ea0056p962 | Male Reproduction | ECE2018

Hematological indices in congenital hypogonadism and the effect of testosterone replacement therapy: A retrospective study

Haymana Cem , Demirci Ibrahim , Dinc Mustafa , Demir Orhan , Akin Onur , Meric Coskun , Aydogdu Aydogan , Sonmez Alper , Azal Omer

Introduction: Patients with hypogonadism are at increased risk for cardiovascular diseases. Mean platelet volume (MPV), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) are hematological indices that are surrogate markers of adverse cardiovascular outcomes. This study investigated the platelet count, MPV levels, PLR, and NLR in patients with congenital hypogonadotrophic hypogonadism (CHH) and also studied the effect of testosterone replacement thera...

ea0049ep362 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Identifiying underdiagnosed or undertreated patients with familial hypercholesterolemia from the central laboratory registries

Haymana Cem , Berlik Hamza , Gunes Yalcin , Tuncez Orhan Enes , Aytekin Cihat , Tapikara Zafer , Guzel Huseyin , Ozturk Ozlem , Barcin Cem , Ozgurtas Taner , Azal Omer , Sonmez Alper

Objective: Familial hypercholesterolemia (FH) is a life-threatening genetic disease associated with elevated low density lipoprotein cholesterol (LDL-C) and premature coronary heart disease that is globally underdiagnosed and undertreated. This study aimed to search for the demographical characteristics, awareness and treatment adherence of underdiagnosed or undertreated FH patients from the records of the central biochemistry laboratory.Methods: Patient...

ea0049ep1165 | Male Reproduction | ECE2017

Endothelial dysfunction, inflammation and insulin resistance in patients with Klinefelter Syndrome

Haymana Cem , Aydogdu Aydogan , Demirci Ibrahim , Dinc Mustafa , Demir Orhan , Torun Deniz , Yesildal Fatih , Meric Coskun , Basaran Yalcin , Sonmez Alper , Azal Omer

Introduction: The prevalence of cardiometabolic disorders such as type 2 diabetes mellitus, dysipidemia and metabolic syndrome is increased in patients with Klinefelter syndrome (KS). The mechanism by which cardiometabolic risk increases in patients with KS remains to be completely elucidated. We investigated the presence of inflammation, insulin resistance and endothelial dysfunction in an unconfounded population of KS.Methods: A total of 31 patients wi...

ea0041ep716 | Male Reproduction | ECE2016

The investigation of oxidative stress-related parameters in congenital hypogonadism

Haymana Cem , Aydogdu Aydogan , Soykut Bugra , Erdem Onur , Ibrahimov Tural , Dinc Mustafa , Meric Coskun , Taslipinar Abdullah , Basaran Yalcin , Sonmez Alper , Azal Omer

Introduction: Patients with hypogonadism are at increased risk of cardiac and metabolic diseases. The pathogenesis of increased cardio-metabolic risk in hypogonadal patients is not clear. Oxidative stress plays an important role in the pathogenesis of cardio-metabolic diseases. The aim of this study was to search for any difference of the oxidative stress parameters between in patients with hypogonadism and healthy controls.Materials and Methods: Thirty ...

ea0056gp89 | Diabetes Epidemiology | ECE2018

Depression screening in adults with diabetes

Demirci Ibrahim , Haymana Cem , Sonmez Yusuf Alper , Bolu Abdullah , Kirnap Nazli Gulsoy , Demir Orhan , Dinc Mustafa , Meric Coskun , Aydogdu Aydogan , Azal Omer

Introduction: Elevated depressive symptoms and depressive disorders affect one in four patients with type 1 or type 2 diabetes (1). Thus, routine screening for depressive symptoms is indicated in this high-risk population. Current guidelines all recommend screening for depression in diabetic population(2). The Patient Health Questionnaire-9 (PHQ-9) is a valid screening tool for depression in individuals with diabetes (3). There is no specific data about the prevalence of depre...

ea0056p965 | Male Reproduction | ECE2018

Triglyceride-Glucose index levels in patients with congenital hypogonadism

Demirci Ibrahim , Haymana Cem , Demir Orhan , Kirnap Nazli Gulsoy , Meric Coskun , Sonmez Yusuf Alper , Gulcelik Nese Ersoz , Aydogdu Aydogan , Azal Omer

Introduction: It is well known that patients with hypogonadism are at increased risk for insulin resistance and cardiovascular diseases. In many studies homeostatic model assessment-insulin resistance (HOMA-IR) formulation is used for the evaluation of insulin resistance. Recently, a simple and inexpensive approach to evaluate for insulin resistance has been developed, the Triglyceride – Glucose (TyG) index. This particular index is based on measuring the levels of fastin...