Endocrine Abstracts

Vitamin D and calcium are necessary for proper modelling and remodelling of osseous tissue and optimal bone mass depends on their appropriate supplementation.Aim of study, materials and methods: The goal of the study was an evaluation of serum vitamin D concentrations (vit. D) in 106 healthy women, aged 20–30 years plus a monthly evaluation – for 3 months – of the effects of calcium (500 mg) and vit. D (1500 IU) administration in women wit...

Introduction: Thyrotropin-secreting pituitary tumors (TSH-omas) are a rare disorder and an infrequent cause of hyperthyroidism. The prevalence in the general population being 1 to 2 cases per million. However, recents studies have demonstrated an increase of TSH-omas over time. The increased number of cases principally results from the ultrasensitive TSH immunometric assays and from improved general practioner endocrinologist awaress. There is an inappropriate secretion of TSH...

Introduction: Subclinical hyperthyreosis (SH) affects about 1.5% population at least. The diagnosis of this disease leans on the laboratory criteria only: decreased of TSH and normal FT3 and FT4 levels. SH increases mortality and there is no unequivocal procedure algorithm to manage patients with this desease.Aim: To estimate an influence of cure of SH on heart rate and on autonomous nervous sytem and to find the relationships between parameters of Holte...

Pasireotide is a a synthetic polypeptide second-generation somatostatin analogue that can be used in the treatment of GH- and ACTH- secreting pituitary neuroendocrine tumors (PitNETs), however, there are single reports of pasireotide treatment in other subtype of PitNETs. We present a case series of aggressive, giant PitNETs treated with pasireotide alone or as multimodal therapy.Case 1: A 33-year-old male reported to the Clinic due to severe headaches a...

Background: Obesity poses a considerable threat to health, increasing the likelihood of accompanying conditions such as type 2 diabetes, hypertension, dyslipidemia, and cancer. Ageing results in the accumulation of damaging factors leading to the development of chronic diseases. Inflammation levels, telomere length, level of neurocognitive function, metabolic age serve as acknowledged indicators of biological aging. The prevalence of premature ageing in obesity has been eviden...

Follicular thyroid carcinoma (FTC) is the second most common type of thyroid cancer, making up about 10 to up to 15% of all thyroid cancers. It is called a ‘well differentiated’ thyroid carcinoma, like papillary thyroid cancer, but it is typically more aggressive than this. We report the case of a 75-year-old man with personal history of Type 1 Diabetes since he was 25 years old, with severe nonproliferative diabetic retinopathy (blindness) and multinodular goiter. I...

Obesity is defined as a state of chronic low-grade inflammation. It is associated with pro-inflammatory activity of visceral adipose tissue, regarded as a neuroendocrine organ that secretes cytotoxins and other pro-inflammatory factors, impairing metabolic pathways. The corollary of these changes is the risk of developing comorbidities. There are many similarities in the mechanisms of ageing and in obesity. The process of ageing leads to the accumulation of pro-inflammatory fa...

Introduction: Dumping syndrome is a phenomenon produced by the alteration of the pyloric sphincter. It occurs in 20% of pyloroplasty or distal gastrectomies. The syndrome is attributed to the rapid emptying of the chyme in the intestine. The osmotic gradient attracts fluid to the intestine, and this releases vasoactive hormones, such as serotonin or vasoactive intestinal polypeptide.Case report: We present a 82-year-old woman with gastric intervention in...

Introduction: Several investigations proved the presence of receptors for androgens, estrogens and progesterone in vocal folds. The most common endocrine disorder causing alterations in the aforementioned hormones concentrations is polycystic ovary syndrome (PCOS), which, according to several studies, can cause voice changes, especially deepening of its timbre. Over last few years, vocal changes accompanying many different disorders have been a subject of research with the use...

Introduction: Treatment of hypothyroidism with levothyroxine is effective and simple; however, international guidelines advise starting with low doses in case of severe hypothyroidism, cardiac illness and aged population. Interestingly, and in contradiction to this dogma, high doses of levothyroxine have been given to patients with myxedema coma without untoward effects. The difference between myxedema coma, which deserves an intensive treatment, and longstanding severe hypoth...