Searchable abstracts of presentations at key conferences in endocrinology

ea0077p71 | Metabolism, Obesity and Diabetes | SFEBES2021

Lipopolysaccharide signalling modulates brown fat transcriptome and cytokine secretion

Omran Farah , Murphy Alice , McTernan Philip , Christian Mar

Background: Brown adipose tissue (BAT) thermogenesis offers an appealing prospect to combat obesity. Obesity is characterised by a state of chronic inflammation in adipose tissue mediated by the secretion of a range of inflammatory-cytokines. Our previous work has highlighted that a gut-derived inflammatory agent, lipopolysaccharide (LPS), reduces brown adipocyte activity, insulin sensitivity and mitochondrial-function and is increased with obesity and type 2 diabetes mellitus...

ea0037ep155 | Reproduction, endocrine disruptors and signalling | ECE2015

Lower peripheral fat persists in HIV-infected subjects despite viral suppression in the era of highly-active antiretroviral therapy

Gangcuangco Louie Mar , Wong Jennifer , Chow Dominic , Shikuma Cecilia

Background: We compared body composition parameters in older HIV-positive individuals on stable antiretroviral therapy to age-matched HIV-seronegative individuals to assess whether differences in body composition parameters persist in the era of potent antiretroviral therapy.Methods: Inclusion criteria to the ageing HIV cohort required subjects to be >40 years old and be on stable antiretroviral therapy for >6 months. Only subjects with undetecta...

ea0070aep933 | Thyroid | ECE2020

Thyroid hormone resistance and succesful gestation with unaffected fetus: A case report

Eugenia López Valverde María , Manzanares Cordova Rossana , Rodriguez Pilar , Inés Velasco López María

Thyroid hormone resistance (THR) is a rare dominantly inherited syndrome characterized by a reduced response of target tissues to thyroid hormone receptor. In most cases, THR is related to mutations in the thyroid hormone receptor beta gene (THRb). Management may be challenging in cases of gestation. Here we report the case of a pregnant patient with a possible not previously described mutation and negative genotype fetus.Case report: Thirty-two year old...

ea0070aep175 | Bone and Calcium | ECE2020

Normocalcemic primary hyperparathyroidism in patients with elevated parathormone (PTH) in a regional health area. A laboratory based approach.

Santana Borja , Alberto Vázquez Luis , Alio Lavín Gómez Bernardo , Pesquera Carlos , Piedra María , García-Unzueta María Teresa

Normocalcemic primary hyperparathyroidism (nPHPT) is still a poorly understood entity, characterized by increased circulating parathormone (PTH) and normal total and ionic calcium, excluding secondary causes.Aim: To characterize the cases of nPHPT detected for a whole year from laboratory records of PTH in a tertiary referral centre, with the purpose of assessing a preliminary estimation and describing their main features.Material ...

ea0070oc9.1 | Reproductive and Developmental Endocrinology | ECE2020

Identification of a novel hypothalamic miRNA/Kisspeptin pathway as pathophysiological mechanism and putative target for management of obesity-induced hypogonadism

Perdices López Cecilia María , Avendaño Herrador María Soledad , Vázquez Villar María Jesús , Barroso Romero Alexia , Ruiz Pino Francisco , Morrugares Carmona Rosario , Correa Sáez Alejandro , Antonio Calzado Marco , Castellano Rodríguez Juan Manuel , Briones Alonso Ana María , Tena-Sempere Manuel

Among its numerous comorbidities, obesity is often linked to central hypogonadism in men, i.e., low circulating levels of gonadotropins and testosterone. While this condition of obesity-induced hypogonadism (OIH) is frequently neglected, it has been suggested to contribute to the metabolic complications of male obesity. However, the mechanisms of OIH, and even its actual role in the metabolic alterations of obesity remain ill defined. Our recent data suggest that OIH is bound ...

ea0070ep18 | Adrenal and Cardiovascular Endocrinology | ECE2020

Adrenal adenoma with hyperandrogenism and virilization in a postmenopausal women

Laura García María , Genovesi Elbio , Rella Noelia , Speroni Romina

Hyperandrogenism and virilization are infrecuent in postmenopausal women and may result from androgen-producing tumors. Androgen-secreting adrenal tumors are rare in clinical practice and often diagnosed as adrenocortical carcinoma, while benign androgen-secreting adrenal tumors are even more rare.Case presentation: A 63-year-old postmenopausal woman in follow-up for hypothyroidism reported hair loss, increased libido accompanied by deepening of the voic...

ea0020p549 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

High TSH levels in healthy pregnant women are related to a decrease in motor development of their children at 14 months of age

Alvarez Mar , Julvez Jordi , Guxens Monica , Rodriguez Agueda , Martorell Rosa , Espada Mercedes , Sunyer Jordi

Objectives: The fetus is dependent on maternal thyroid hormones during pregnancy and an adequate thyroid function during pregnancy is essential for the normal brain development. The effects of subclinical hypothyroidism during pregnancy are poorly known. The present study assesses the association between thyroid hormones and thyrotropin in healthy pregnant women from the general population, and the neurodevelopment of their children at the age of 14 months.<p class="abstex...

ea0073aep542 | Pituitary and Neuroendocrinology | ECE2021

Descriptive analysis of patients with Multiple Endocrine Neoplasia type 1. Experience at a tertiary hospital

Rosa María García Moreno , Gomes-Porras Mariana , Lecumberri Beatriz , Cristina Álvarez Escolá

BackgroundMultiple Endocrine Neoplasia type 1 (MEN 1) is a genetic syndrome caused by inactivating mutations of the menin gene, which predisposes to the development of endocrine tumors. The causative mutations, clinical manifestations, and age of tumor development are highly variable. The objective of this study is to describe the characteristics of patients with MEN1 in our hospital.Material and methodsWe pe...

ea0099p58 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Biometric and metabolic changes at one-year follow-up in patients with obesity and steatotic liver disease undergoing endoscopic sleeve gastroplasty-endosleeve (apollo method)

Schwarzstein Diego , Batista Lissette , Goncalves Patricia , Yip Luis , Bustillos Leoniana , Bacardit Mar , Colomer Cristina , Merlo Josep

Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly called non-alcoholic fatty liver disease, NAFLD) is a leading cause of chronic liver disease, affecting 25% adult population worlwide. Its most advanced form is the metabolic dysfunction-associated steatohepatitis, or MASH which may progress to cirrhosis. It has no approved pharmacotherapy yet, and weight reduction is an important therapeutic option. Few studies have evaluated the effect of...

ea0070aep317 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Pancreas-kidney transplantation improves quality of life in type 1 diabetes patients

Dolores Alcántara-Laguna María , Durán-Martínez Manuel , Calleja-Lozano Rafael , Manuel Sánchez-Hidalgo Juan , Ángeles Gálvez-Moreno María

Introduction: Diabetes is increasing its prevalence as an enhancement of treatment options arises and mortality declines. Pancreas transplantation has been postulated as one of them, specifically indicated for cases with end-stage renal failure where kidney transplantation is required besides. It has been analysed whether there is a clinical benefit in terms of quality of life (QoL) in patients undergoing pancreas-kidney transplantation (PKT) compared to dyalisis population or...