Endocrine Abstracts

Plasticisers such as bisphenol A (BPA), bisphenol S (BPS), and phthalates (PAE) are commonly used in daily life in electronic equipment, cans, plastic food containers, and bottles. These substances can interact with oestrogen receptors as well as androgen receptors and therefore they are called endocrine disrupting chemicals (EDC). The aim of this study was to evaluate serum concentrations of BPA, BPS, and selected PAE in healthy women and women with polycystic ovary syndrome ...

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, that lead to infertility, type 2 diabetes and coronary heart disease.Bisphenol A (BPA) is one of the most abundant chemicals produced worldwide and is used as a plasticizer in daily life. Nowadays it is also well know that it can interact with estrogen receptors, androgen receptors and peroxisome proliferator-activated receptors γ (PPARγ). Therefore...

The aim of the study was to estimate thresholds of android fat mass and android to gynoid fat mass ratio at which metabolic disorders and blood pressure typical of metabolic syndrome appear. Classification and Regression Trees models were used to estimate these thresholds for glucose, HDL cholesterol, triglycerides and systolic and diastolic blood pressure.Methods: healthy postmenopausal women were recruited for the study. Blood samples were collected fo...

The aim was to assess associations among metabolic abnormalities in polycystic ovary syndrome (PCOS) and NAFLD.Materials and methods: In 184 women with PCOS and 125 healthy premenopausal volunteers sex steroids, lipids, glucose, insulin, aminotranspherases, CRP, free androgen index (FAI), HOMA and E2:testosterone were calculated. Hepatic steatosis was determined by ultrasound. The analysis of multivariate (logistic regression) due to the prese...

Postmenopausal osteoporosis is a condition that appears as a result of a sudden reduction in E2 production by the ovaries. The earliest is manifested by the reduction of lumbar BMD; mostly consisted of trabecular bone. Proximal femur is built mostly of cortical bone, and so is aging more slowly, but femoral fracture more often lead to disability and death. The aim of the study was to check which from the anthropometric, hormonal and biochemical markers have the infl...

The aim of this study was to determine whether polymorphisms (TaqI, ApaI, BsmI, and FokI) of the vitamin D receptor (VDR) show a correlation with the serum level of the testosterone in the aging men population.A group of 224 men aged 65–90 years, randomly selected from the group of 5695 persons included in the PolSenior project was studied. We established genotype prevalence of the VDR gene polymorphisms (TaqI, rs10735810; ApaI, rs1544410; BsmI, rs7...

Recently, low serum adiponectin levels is created as a new risk factor for cardiovascular diseases in climacteric women. Our previous study shows that smoking, serum testosterone levels, blood pressure and BMI have the influence on serum adiponectin levels. Endocannabinoid system plays a role in regulation of food intake and fat accumulation, as well as lipid and carbohydrate metabolism. Menopause transition is related to metabolic disorders (e.g. obesity) and cause the increa...

Introduction: Mechanisms by which visceral obesity and insulin resistance (IR) contribute to atherogenesis are complex and not entirely known. One of the atherogenic factors involved in foam cells formation is scavenger receptor CD36 expressed on monocytes, endothelial cells, adipocytes and platelets, participating in oxidized LDLs absorption and foam cells formation – processes that initiate atheroslerosis. Many factors can influence the expression of receptor CD36.<...

Background/Aims: Calcium and vitamin D malabsorption in celiac disease predispose to skeletal demineralization. The aim of this study was to evaluate the prevalence of bone mineral density (BMD) and calcium deficiencies in adult patients with CD and assess whether a gluten-free diet is sufficiently effective for BMD restoration or whether calcium and vitamin D should be applied.Methods: BMD and biochemical parameters of bone and mineral metabolism were m...

Introduction: Polycystic ovary syndrome (PCOS) is associated with metabolic disorders such as insulin resistance, hyperinsulinemia, dyslipidemia and central obesity which increase the risk of cardiovascular diseases (CVD). Lipid accumulation product (LAP) and waist circumference to height ratio (WHtR) are novel CVD risk predictors based on the assessment of waist circumference, height and serum triglycerides. The aim of our study was to evaluate the LAP and WHtR associations w...