Endocrine Abstracts

Objective: Prolactin has been adversely associated with arterial function in postmenopausal women but its vascular effects in reproductive women are unknown. Furthermore, although both circulating prolactin levels and markers of vascular function follow menstrual cycle (MC) phases, their possible inter-correlation has not been explored.Methods: Sixty healthy premenopausal women were evaluated in two distinct phases of their MC (follicular, F and luteal p...

Objectives: Patients suffering from pulmonary or/and neoplastic disease are at higher risk of developing serious illness from SARS-CoV-2. TC patients with lung metastases are classified as high-risk for severe CoV-2 disease. Aim of this study was to investigate SARS-CoV-2 prevalence and severity in this particular subgroup of patients.Methods: Out of 28 patients with metastatic Differentiated Thyroid Cancer (DTC) and 21 patients with met...

Introduction: The maximum period of bisphosphonate use has not been determined, as their long-term appliance has been associated with adverse effects, such as osteonecrosis of the jaw (ONJ) and atypical femoral fractures (AFF).The aim of this study was to systematically present existent data regarding the effect of bisphosphonate discontinuation on fracture risk and bone mineral density (BMD).Methods/design: MEDLINE, Scopus, EMBASE...

Introduction: The aim of this study was to investigate the incidence of glycemic disorders in patients undergoing coronary angiography with no prediagnosed type 2 diabetes (T2D), as well as the association of the glycemic status with the extent of the coronary artery disease (CAD).Patients and methods: We studied 170 consecutive patients (134M/36W), 63.9±13.1 (23–95) years old, with not known T2D, who underwent coronary angiography. HbA1c was m...

Introduction: T regulatory lymphocytes (Tregs) are defined as CD4+CD25high T lymphocytes and are thought to regulate immune tolerance. The Foxp3 protein level in Tregs is proportional to CD25 protein surface expression and regulatory function, but inversely proportional to IL-7R (CD127) level, the receptor for the growth and survival of T cells. We investigated possible differences in Tregs between newly diagnosed type 1 diabetes (DM1) patients and contro...

Introduction: Discontinuation of denosumab may rarely lead to rebound fractures, although the evidence is low, since available data have derived from case reports and post-hoc analyses.Case presentation: A 45-year old Caucasian male was presented at the outpatient clinic in February 2016 for evaluation and management of severe osteoporosis, which had been complicated with multiple vertebral low energy fractures at the 10 th to 12th ...

Introduction: Patients with multiple sclerosis (MS) demonstrate, in a number of studies, increased risk of acquiring another autoimmune disease compared to general population. Autoimmune thyroid diseases, type 1 diabetes, psoriasis and inflammatory bowel disease are the most common reported. The aim of our study is to determine potential factors that affect the presence of autoimmune endocrinopathies in patient with relapsing and remitting MS.Methods: We...

Objective: Flash Glucose Monitoring (FGM) is becoming increasingly popular among children with Type 1 diabetes. Our aim was to evaluate real-life data from children using FGM followed in our center.Methods: We studied 37 patients (51.4% males), with a mean±S.D. age of 10.1±3.9 years at FGM start for a period of 10.1±6.5 months. HbA1c, BMI z-score, number of self-reported and severe hypoglycemias, total insulin daily dose/kg ...

Introduction: Several markers based on anthropometric and biochemical parameters like fatty liver index (FLI), lipid accumulation product (LAP) index and visceral adiposity index (VAI), have been proposed for the detection of nonalcoholic fatty liver disease (NAFLD).Objective: To evaluate the diagnostic performance of FLI, LAP and VAI as markers of NAFLD in premenopausal women with and without polycystic ovary syndrome (PCOS), assessed for hepatic steato...

Introduction: Thyroid hormones and irisin increase energy expenditure and induce browning of adipose tissue. However, little is known about irisin physiology and regulation. Here we aim to elucidate whether thyroid hormones alter circulating irisin concentrations in humans.Design and subjects: One cross-sectional (case-control) evaluation and two interventions were performed independently from each other, including previously thyroidectomized patients. C...