Endocrine Abstracts

Cellular Ca2+ signals have been proposed to activate signal for hormone secretion. In pancreatic β cell which produce insulin, Ca2+ signals have been known contributing insulin secretion. Prior to conduct this study, we confirmed calbindin-D9k (CaBP-9k) which responsible for regulation of the distribution offree calcium in the cytoplasm. Hypoxic condition induces endoplasmic reticulum(ER) stress, increase both insulin signaling and insulin resistance. Byexposing hypoxia, ...

Background: A variety of insulin analogs have been developed and used for the treatment of diabetes mellitus. We often experience elevated serum insulin levels when insulin analog is used, and thus have difficulty in assessing insulin resistance and secretion using serum insulin results. This study aimed to investigate the differences in serum fasting insulin level and insulin antibodies according to the type of insulin analogs.Method: We conducted a ret...

Background: Lipoprotein (a) (Lp(a)) is a low-density lipoprotein like particle which has proatherogenic and a prothrombotic properties. Therefore, increased Lp(a) levels have been reported to be associated with a higher cardiovascular risk in numerous studies. However, the association between Lp(a) and metabolic disorders such as diabetes or metabolic syndrome (MetS) is still controversial. This study aimed to examine the association between Lp(a) levels and presence of MetS i...

Congenital hypogonadotropic hypogonadism (CHH (MIM161110)) due to GnRH deficiency is a rare genetic disorder (affects ~1/30 000) characterised by abnormal pubertal development and infertility. Over 60% cases have anosmia (Kallmann syndrome) and some exhibit additional phenotypes. CHH is a genetically heterogeneous developmental disease. Most cases present sporadically, although familial forms (AD, AR, and X-linked) with incomplete penetrance and variable expressivity occur. Re...

Purpose: Aster spathulifolius Maxim is one of plants of chrysanthemum, which has shown an anti-obesity activity in diet induced mice model. We performed clinical trial for evaluating the anti-obesity efficacy and safety of Aster spathulifolius Maxim extract on obese human.Methods: This study was randomised, double-blind, placebo-controlled clinical trial in Korea. A total of 41 obese subjects (BMI 25–30 kg/m2) aged ≥20 years were ra...

Objective: Cathepsin L can control adipogenesis and relate to acute coronary syndrome. However, it is not clear whether cathepsin L can be affected by saturated fatty acid and decrease by curcumin. We examined the hypothesis that palmitate upregulates cathepsin L expression in adipose tissue and curcumin can be block that effect.Methods: 3T3-L1 cells were fully differentiated for 8 to 10 days and treated with palmitate, LPS, IL6, TNF-α, IL6 neutrali...

Background: Recently, the triglyceride glucose (TyG) index has been considered a surrogate marker of insulin resistance. Insulin resistance is a well known pathogenic factor in nonalcoholic fatty liver disease (NAFLD). However, few studies have investigated the relationship between the TyG index and liver fibrosis in subjects with NAFLD. Thus, we investigated the relationship between the TyG index and liver fibrosis in Korean adults.Methods: In total, 51...

Thyroid dysfunction is associated with increased risk of cardiovascular disease (CVD) in general population, but it remains controversial whether the treatment of differentiated thyroid cancer (DTC) including thyroidectomy and thyroid stimulating hormone suppression add any risk of CVD compared to general population. We performed a systematic review of observational studies reporting associations between DTC and CVD in MEDLINE, EMBASE, Web of Science and other source (PROSPERO...

Objectives: NTRK gene fusions are oncogenic drivers in many solid tumours, including thyroid cancers. In the phase 2 study STARTRK-2 (NCT02568267), entrectinib (a CNS-active tropomyosin receptor kinase [TRK] inhibitor) demonstrated efficacy in patients with NTRK-fp thyroid cancer (objective response rate [ORR]: 40%; clinical cut-off: 31 Oct 2018; n=5). We report updated data from a larger cohort with longer follow-up.Methods: A...

Objective: Apolipoprotein B/Apolipoprotein A-1 ratio (Apo B/Apo A-1) and lipoprotein (a) (Lp(a)) are known to be associated with atherosclerotic vascular disease. We investigated the influence of Apo B/Apo A-1 and Lp(a) on coronary artery calcification (CAC) among healthy Korean adults.Methods: A total of 1081 participants underwent cardiac computed tomography in health promotion center were enrolled. Anthropometric profiles and multiple cardiovascular r...