Endocrine Abstracts

Introduction: Thyrotoxicosis as well as its treatment with Carbimazole (CBZ) or Propylthiouracil (PTU) have been reported to result in myopathy. Onset of myalgia during the treatment of thyrotoxicosis may cause a diagnostic challenge in distinguishing the thyrotoxic from the drug-induced myopathy. We report such a case where myopathy was induced by treatment with both CBZ and PTU.Case report: We report the case of a 26-year-old Chinese lady presenting wi...

Significant hyperglycaemia suppresses beta cell replication and cell cycle progression. Acute beta cell failure is caused by several mechanisms involving oxidative and endoplasmic stress leading to DNA damage response (collectively termed glucotoxicity) (1). Short-term glycaemic control unmasks the regenerative potential of beta cells, leading to recovery and potentially weaning off Insulin therapy (1, 2, 3). We present a case of a 62-year-old woman with ...

Introduction: Amenorrhea is a frequent cause of Endocrinology clinic attendances. While causes like menopause, thyroid disorders and hyperprolactinemia are common, less common aetiologies need to be considered, especially the inherited ones that could affect a patient’s family. Identifying rare conditions requires constant vigilance, as well as clinical experience and the knowledge of the diagnostic criteria.Case report: We report the case of a 39-y...

Numerous studies have identified several extra-skeletal health outcomes to be associated with vitamin D deficiency, yet a definitive causal link is yet to be discovered. Our recent 3D LC-nESI-FTMS proteomic analysis among normal and overweight but apparently healthy adult Saudis identified apolipoproteins, a known independent cardiovascular risk factor, as one of the serological molecular signatures that modulate vitamin D levels. The present interventional study aims to compa...

Introduction: Majority of patients with neuroendocrine tumors (NET) harbor hepatic metastases at presentation, posing therapeutic challenge. Multiple liver-directed treatment modalities have been employed with variable success. Herein is presented successful outcome in a patient whose recurrent metastatic liver metastases from NET was managed using multidisciplinary approach.Case report: We present long-term18-years course of a patient with liver metasta...

Kallmann syndrome is a rare congenital hypogonadotropic hypogonadism with variable degrees of hyposomia to anosmia. This syndrome can be transmitted as autosomal dominant, autosomal recessive and X-linked inheritance pattern. We are reporting two cases of young male siblings (17 and 16 years old) who are the offspring of unrelated parents, presenting with delayed puberty and both were complaining of hyposmia. Their older brother, aged 24 years, was diagnosed with isolated hypo...

Introduction: Short stature and hypothyroidism and are frequent complications of thalassemia major (TM).Patients and methods: We recorder growth parameters and investigated the thyroid function in TM patients attending our Pediatric Endocrine Clinics for 12 years. Definitions: overt hypothyroidism (low FT4 and increased TSH levels >5 μIU/ml); subclinical hypothyroidism (normal FT4, TSH between 5–10 μIU/ml) and cen...

Hypovitaminosis D is associated with an increased prevalence of diabetes mellitus type 2 (DMT2) and the metabolic syndrome. The purpose of this study was to examine the association between 25-hydroxy-vitamin D (25-OH-VitD) levels and adipocytokines and other indices of insulin resistance in a Saudi population with DMT2. One-hundred and fifty-five male and female Saudi adults aged 26–80 were randomly selected from the existing Biomarkers Screening in Riyadh Program (RIYADH...

We studied the association between RBP4 and various markers related to insulin resistance and diabetic complications as well as inflammatory markers in Saudi population suffering from type 2 diabetes and coronary heart disease. Patients with type 2 diabetes were divided into 3 groups according to the type of treatment and involvement of coronary artery disease. Serum TNF-α, insulin, CRP, resistin, leptin and adiponectin were analysed in all samples. RBP4 plasma levels inc...

Objectives: This study was conducted to evaluate the effect of lamotrigine (LTG) & carbamazepine (CBZ) on reproductive hormones (follicle-stimulating hormone (FSH), luteinizing hormone (LH) & total testosterone), lipid profiles (total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) & very low density lipoprotein (VLDL)), ovarian weight & histology in non epileptic female rats.Materials an...