Endocrine Abstracts

Introduction: Calcitriol-mediated hypercalcemia is one of the most common paraneoplastic syndromes associated with lymphoma.Aim: Evaluate clinical and biochemical manifestations as well on the management of hypercalcemia in patients with lymphoma.Materials and methods: Prospective analysis of patients with lymphoma who developed hypercalcemia during September-2011 and January-2016.Results: Two hundred and six...

Introduction: Mutations activating USP8 have been detected in a high proportion of pituitary adenomas causing Cushing’s disease and have been linked to an increase of ACTH production in corticotroph cells. Whether USP8 mutations are involved in the tumorigenesis of the ectopic Cushing’s syndrome (ECS) caused by neuroendocrine tumors has not been studied.Patients and methods: In this work we evaluate the role of USP8 in a series of 17 t...

Introduction: Recent studies have pointed out a possible role of vitamin D in carcinogenesis. Vitamin D deficiency may be related to a major cancer incidence and mortality. This association would be more relevant for breast and colorectal cancer. Obesity acts as a risk factor for these type of neoplasms on which vitamin D could influence.Subjects and methods: A cross-sectional study of consecutive out-patients with newly diagnosed cancer: urological, col...

Introduction: New treatments of diabetes, such as dapagliflozin, improve global metabolic status beyond glycemic control.Aim: To evaluate tolerance to dapagliflozin and its effects on metabolic control in type 2 diabetes and obese patients attended in endocrinology offices.Material and method: A prospective study of patients with type 2 diabetes and obesity. In an intra-subject analysis, clinical and analytical data were evaluated ...

In our centre, thyroid core-biopsy (CB) has replaced fine needle aspiration biopsy (FNAB) in the study of thyroid nodules because its better accuracy. International guidelines recommend repeating the FNA in cases of inadequate or insufficient first specimen, but nothing is published about the case in failed CB.Objective: To study the differences between nodules with inadequate and diagnostic thyroid Core Biopsy and the accuracy of repeating a CB after a ...

Transsphenoidal adenomectomy (TSA) is the recommended primary therapy in most patients with acromegaly and results in remission for majority of microadenomas and a proportion of macroadenomas depending on extent of surgically accessible disease. Acromegaly is associated with significant mortality and morbidity, hence a combination of treatment modalities may be needed to achieve disease control.Methods: A retrospective casenotes review was conducted and ...

Context: Insulin resistance is an important component of polycystic ovary syndrome (PCOS). Local cytokine production in adipose tissue increases local insulin resistance. The effect of testosterone on local adipose tissue cytokine production has not been explored thoroughly.Aim: To evaluate cytokine expression in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) from PCOS and control women and evaluate the response to testosterone on th...

Rationale: Low level of vitamin D can results in secondary hyperparathyroidism (SH) that has been linked to increased cardiovascular risk in general population. However, the spectrum of cardiovascular risk associated with SH in HIV-infected adults remains uncertain. Our main aim was to determine its potential association with different markers of cardiovascular risk in HIV-infected adults.Methods: Cross-sectional study. Clinical data related to obesity, ...

GLP-1 is a gut hormones with insulinotropic effects. GLP-1 is expressed at the hypothalamus having regulatory functions in food intake and neuroendocrine corticoadrenal axis (HPA). Energy balance and HPA have deep influence in the gonadal function of mammals. Exendin-4 (Ex4) is a potent agonist for the GLP-1 receptor.Objectives: To evaluate the effects of native GLP-1 (7–36)-NH2(GLP-1) and Ex4 in the function of the reproductive system in adulthood ...

Rationale: Type 2 diabetes mellitus (T2DM) is a well known independent prognosis factor associated with cirrhosis. Nevertheless, few studies are focused on the association between glucose metabolism and liver fibrosis in HCV/HIV patients and their conclusions are contradictory. The aim of our study was to investigate the relationship between glucose homeostasis and liver fibrosis in these patients.Methods: In a cross-sectional study, we compared prevalen...