Endocrine Abstracts

Background: Rapid and accurate risk stratification in patients with community-acquired pneumonia (CAP) is an unmet clinical need. Cortisol to DHEA ratio was put forward as a prognostic marker in sepsis. We herein validated the prognostic value of DHEA and DHEAS and of cortisol/DHEA- and cortisol-DHEAS – ratios, respectively, in patients with CAP as the most common (disease resulting) sepsis-defining illness.Methods: We assessed clinical parameters a...

While bariatric surgery is the most effective treatment strategy to maintain long-term weight-loss and to improve survival, it has not been shown, that bariatric surgery is as effective in craniopharyngeoma patients with hypothalamic obesity. We retrospectively analyzed weight loss and metabolic parameters in 7 craniopharyngeoma patients and 14 controls who underwent gastric banding surgery in five centers in Germany and Austria. The last before and the first patient after the...

Due to limited treatment options the prognosis of patients with advanced hepatocellular cancer (HCC) has remained poor. We therefore examined the feasibility of radioiodine therapy of HCC after human sodium iodide symporter (hNIS) gene transfer, using the tumor-specific alpha-fetoprotein (AFP) promoter for transcriptional targeting. For this purpose NIS gene transfer was performed in vivo in human HCC cell (HepG2) xenografts, using replication-deficient adenoviral vecto...

Objective: Cinacalcet, a calcimimetic that reduces parathyroid hormone (PTH) secretion and serum calcium (S-Ca) levels by increasing the sensitivity of calcium-sensing receptors has been introduced for the treatment of patients with persistent or recurrent primary hyperparathyroidism (PHPT). Within a prospective, non-interventional cohort study we identified patients with newly diagnosed PHPT who have been started on cinacalcet. Patient characteristics, treatment indications a...

Objective: The Swiss Primary HyperParaThyroidism (PHPT) Cohort Study is an ongoing, prospective, non-interventional project collecting clinical, densitometric, biochemical and outcome data in patients with PHPT. The aims are to describe the profile of these patients particularly neurobehavioral and cognitive symptoms, changes in calcium and PTH over time and treatment modalities.Methods: Patients newly diagnosed with PHPT and with high serum calcium leve...

Context: An interaction between gut-derived ghrelin, which is implicated in the regulation of short- and long-term energy balance, and thyroid function has previously been reported in patients with hyperthyroidism, in whom ghrelin levels are reversibly suppressed. In the present study, we measured total serum ghrelin levels and pertinent metabolic indices in hypothyroid patients before end after L-thyroxin replacement.Patients and methods:...

OPUS is a population-based prospective cohort study of post-menopausal women from five European cities. We investigated whether TSH, fT4 and fT3 are associated with fracture risk, bone mineral density (BMD) at hip and spine, bone formation (osteocalcin, procollagen type 1 N-terminal propeptide), bone resorption (N- and C-telopeptides of type 1 collagen, NTX, CTX), pulse rate, grip strength and balance. Vertebral fractures were determined at baseline and 6 years follow-up. Usin...

(This poster is based on OC33)...

Background: Non-alcoholic fatty liver disease (NAFLD) is recognized as common liver disorder that represents the hepatic manifestation of the metabolic syndrome including visceral obesity, type 2 diabetes, insulin resistance and hyperlipidemia. Non-alcoholic steatohepatitis (NASH) is the progressive form of liver injury with the risk for progressive fibrosis, cirrhosis and end-stage liver disease. The pathophysiology that leads to NAFLD and NASH is not well understood. We hypo...

The mechanisms responsible for the progressive failure of hypoglycemia counter-regulation in type-1 diabetes (T1DM) are poorly understood. Alterations of brain energy metabolism could influence glucose sensing by the brain and, thus contribute to hypoglycemia associated autonomic failure. Thus, we measured intraneuronal kinetics of total ATP-synthesis from PCr (kfor) in T1DM patients and effects of hypo/hyperglycemia on this brain energy metabolism. Healthy n...