Endocrine Abstracts

Background and objectives: Hyperglycaemic emergencies (HE) are the most common acute complication of diabetes and are associated with relative or absolute insulin deficiency, volume depletion, impaired mental status and metabolic derangements. Hyperglycaemic emergencies are associated with high morbidity and mortality if not properly managed. We investigated the pattern of hyperglycaemic emergencies at Obafemi Awolowo University Teaching Hospital, Ile-Ife, South-western Nigeri...

Neuroendocrine tumours have a number of different classification and staging systems. I will present the latest of these, which include the latest WHO system with the implications for new entities and how they are diagnosed pathologically and any difficulties that arise from this. There will also be a more general discussion about areas that are difficult for the pathologist and where we can add value to the MDT discussion....

An increasing proportion of people living in our 24/7 culture complain about insomnia symptoms, i.e., they experience problems to fall and/or stay asleep. As demonstrated by epidemiological studies, chronic sleep loss is correlated with weight gain. To investigate whether sleep loss would alter energy metabolism in favour of weight gain, my lab therefore performed a series of sleep loss experiments in metabolically healthy normal-weight subjects. These studies demonstrated tha...

Recent advances in tridimensional (3D) tissue imaging and development of reporter proteins have provided new insight into the dynamic relationship between tissue structure, function and dysfunction in a number of fields of research. In developmental biology 3D microscopy has enabled building of quantitative 3D atlases of embryo morphology and gene expression at cellular resolution and in neuroscience ‘connectomics’, the building of 3D brain connectivity maps is a rap...

Three independent studies identified SNPs in the first intron of the gene FTO as being strongly and consistently associated with BMI and/or obesity at significance levels (P=10−7 to P=10−30) unobserved so far in genetics of obesity. The three studies estimated the putative effect around 1% of the total variance of BMI. So far, this represents the strongest effect for a common variant in obesity.This result ...

Glucocorticoids act within the pituitary gland to maintain the blood levels of glucocorticoids within appropriate limits by negative feedback on the secretion of corticotrophin (ACTH). Annexin 1 (ANXA1) is a calcium- and phospholipid binding protein which was originally identified as a mediator of the anti-inflammatory actions of glucocorticoids in the host defence system. Subsequent work has shown that it that plays an important role in the early delayed (30 min-3 h) feedback...

Background & Aims: NutriAct is a 36-month randomized controlled multi-center trial aiming to analyze the effects of a dietary pattern focusing on a high-protein and high-unsaturated fatty acids (UFA) intake on healthy aging. We aimed to explore changes in intake of macronutrients and determine factors associated with a successful modulation of dietary pattern after 36 months in elderly community dwelling participants.Methods: 502 participants were ra...

BackgroundOrthodox religious fasting (OF) is a variation of the classical Mediterranean Diet during which meat and other animal products are restricted, whereas fish are occasionally and sea food are always allowed. The aim of this prospective study was to assess sex-specific differences in changes of lipid concentrations in a cohort of metabolically healthy adults following OF and investigate a potential role of vitamin D status in mediating these varia...

Aim: To analyze the safety, efficacy and dosimetry of Lu-177 labeled prostate specific membrane antigen (PSMA) ligand 617 in patients with progressive metastatic castration-resistant prostate cancer (mCRPC), in comparison with Lu-177 PSMA I&T.Methods: Lu-177 PSMA-617 radioligand therapy (PRLT) was performed in 64 mCRPC patients. The median administered activity per treatment was 6 GBq. Ga-68 PSMA PET/CT was used for patient selection and follow-up. H...

Over the past several years, growing evidence suggested that serum cortisol is associated with increased cardiovascular (CVD) mortality in patients with chronic heart failure. The prognostic significance of serum cortisol concentration (SCC) in patients with acute coronary syndrome (ACS) however is unknown.In the prospective Ludwigshafen Risk and Cardiovascular Health (LURIC) study 3316 patients (median age: 63.5 (56.3–70.6) years; 30.2% women) were...