Endocrine Abstracts

Introduction: Ectopic thyroid tissue is a rare embryonic developmental defect that occurs during the thyroid transition from its initial position in the floor of the primitive bowel to a pre-tracheal location. This defect has a prevalence in the general population of 0.3–1/100,000 inhabitants, increasing to 0.5–1/4,000 patients with thyroid pathology. It is more common in women and can be diagnosed at any age, with diagnosis being more common in young individuals.</p...

Obesity is growing fast worldwide. Although environmental factors play a major role, endocrine dysfunction may contribute to the weight gain. We report an invasive macroprolactinoma diagnosed in obesity setting. A 35-year-old male was referred to our endocrine outpatient department due to grade 2 obesity (IMC 38.4 Kg/m2). His weight was increasing since the beginning of his professional activity at the age of 20 due to a sedentary lifestyle. On physical examination he had an h...

Introduction: Ophthalmopathy and dermatopathy are the most frequent manifestations of Graves Disease (GD). It is also known the relation between GD and other autoimmune diseases like myasthenia gravis. Thymus hyperplasia in GD is already documented on literature but it’s mechanism is not well understood. There are two possible explanations, one related to thyrotrophin receptors stimulation present on thymus, and other related to tissue stimulation due to generalized hyper...

IntroductionSimultaneous pancreas-kidney transplantation (PKT) has a beneficial effect on the evolution of chronic complications in type 1 diabetic (T1D) patients with terminal chronic kidney disease (CKD). However, the CKD-mineral and bone disorder (CKD-MBD) remains a frequent complication. There are a few studies addressing the long-term evolution of bone mineral density (BMD) in these patients.AimTo charac...

Morphometric-Vertebral Fractures (VFs), which were widely demonstrated to reduce overall-survival and respiratory function in the general population, have been recently reported to be highly prevalent in COVID-19 patients. Emerging data show negative respiratory sequelae at long-term follow-up in COVID-19 survivors. The aim of this study is to evaluate the VFs influence on respiratory function of COVID-19 survivors. We included COVID-19 patients admitted at San Raffaele-Hospit...

Medullary thyroid cancer (MTC) is a rare malignancy of the thyroid gland. MTCs originate from thyroid-C cells and account for 2-4% of all thyroid neoplasms. Originating from thyroid-C cells, the main secretory product of MTCs is calcitonin, used as sensitive and specific MTC-biomarker. Calcitonin is a hormone known to participate in calcium-bone metabolism suppressing bone-resorption by inhibiting the activity of osteoclasts, and inhibiting the kidney reabsorption of calcium a...

Background: Pituitary adenomas in children/adolescents represent around 3% of all intracranial neoplasms. They are more frequently hormone-secreting lesions, usually diagnosed in early childhood and late adolescence. Female gender is generally prevalent, because of most evident symptoms (i.e., irregular periods, galactorrhea, etc.). Giant pituitary adenomas (GA) very rarely occur in pediatric age, posing frequent challenges in their management.Patients a...

Growth hormone deficiency (GHD) has become increasingly recognized as a cause of metabolic syndrome, characterized by altered body composition and adverse cardiovascular risk. The effects of other pituitary hormone deficiencies or their replacement therapies on the metabolic profile in this clinical setting are still largely unclear. In this study, we aimed to evaluating the effects of replacement therapies of central hypoadrenalism and hypothyroidism on body composition in a ...

Over the last years, there has been evidence that acromegaly may cause skeletal fragility with high risk of vertebral fractures. The diagnostic approach to this complication is still a matter of uncertainty, since DXA measurement of bone mineral density (BMD) does not provide reliable information on fracture risk in acromegaly. The cone beam computed tomography (CBCT) technique offers three-dimensional images for the radiographed area with the advantage to use non-dedicated eq...

Introduction: Recent studies showed that morphometric vertebral fractures (VF) are an early and frequent complication in patients (pts) withhyperfunctioning pituitary adenomas and hypopituitarism (independently from the etiology). GH excess or severe deficiency play a negative key role on bone health in this clinical setting. Disease control or adequate replacement therapies still remain a cornerstone for the clinician to reduce the burden of osteo-metabolic complications. To ...