Endocrine Abstracts

Introduction: Paraganglioma (adrenal or extra-adrenal) in pregnancy is a rare condition with a high maternal and foetal mortality rate. A multidisciplinary approach is important as it will influence the maternal and foetal outcome. This is illustrated in the following case report.Case report and results: A 32-year-old woman was referred because of persistent hypertension at 33 weeks of pregnancy. There were no spontaneous complaints of headache, palpitat...

Dr David Unwin MbChB FRCGP Our GP practice of 9500 people has suffered an eight-fold increase in the number of patients with T2D since 1986. In addition, those affected now develop this condition decades earlier than was the norm back in 1986. A situation replicated all over the developed world. Nationally there are 122,780 children and young adults under the age of 40 years with type 2 diabetes, 1,560 (around 1.3 per cent) are under the age of 19 years. In 2013 our practice d...

Introduction: Various methods to quantify calcified coronary plaque have been used in common clinical practice in the past few decades to compliment cardiovascular risk assessment. The estimation of calcium load in other organs and conditions has been at best semi-quantitative. Patients with long-standing hypoparathyroidism are known to suffer with nephrocalcinosis and basal ganglia calcification. We attempted to quantify end-organ calcium burden in a series of patients with v...

Background and Objectives: Fasting causes a major change in the dietary habits including the frequency, the timing, and the patterns which will result in a major change in the metabolic response of the body. Physicians should advise the patients about the complications of diabetes mellitus during fasting especially hypoglycemia, the aim of this study is to determine the relation between type 2 diabetes mellitus and hypoglycemia and to evaluate whether this correlation is signi...

SIMBA (Simulation via Instant Messaging- Birmingham Advance) is a novel pedagogical simulation-based learning model which improves clinicians’ confidence in managing conditions in endocrinology and diabetes. More than 25 SIMBA sessions have been conducted between May 2020 and August 2022. Each session included 4 to 6 real-life anonymised case scenarios followed by an interactive discussion. SIMBA effectively adopts Kolb’s theory to provide the best possible experienc...

Introduction: US Food and Drug Administration (FDA) has recently approved bexagliflozin, a new SGLT2 inhibitor. We examined the outcomes and metabolic effects of Bexagliflozin across the published Randomised Controlled Trials (RCCTs)Methods: A comprehensive literature search was done to extract publications from Medline-PubMed and Cochrane library, since inception till January 20, 2023, then screened and reviewed by two independent reviewers. Data includ...

Some hypoparathyroid women report the appearance or intensification of hypocalcemia symptoms at the time of menses. It is still unknown whether this is the result of premenstrual syndrome or fluctuations in serum calcium levels. Studies have not found a relationship between fluctuations in levels of sex hormones and serum calcium and phosphorus and it appears probable that they affect neuromuscular excitability through a separate mechanism. Alterations in serum calcium levels ...

Background and Aim: Diabetic neurogenic bladder (DNB) is a frequent complication affecting up to 45% of patients suffering from diabetes mellitus (DM). Our study aims to evaluate the impact of DNB on the quality of life (QoL) in this population.Patients and Methods: We conducted a descriptive cross-sectional study involving 200 patients with DNB. Their QoL was assessed using the Ditrovie scale.Results: The mean age was 59.3±10.6...

Objective: to analyze the dietary and metabolic factors predictive of the occurrence of pancreatitis in patients with type 1 diabetes mellitus (T1DM).Patients and Methods: Analytical case-control study of 31 T1DM patients separated into two subgroups: G1 (n=10): T1DM cases with pancreatitis. G2 (n=21): T1DM controls without pancreatitis.Results: The age at diagnosis of T1DM was comparable between the two groups. A...

Introduction: Musculoskeletal disease is one of the common symptoms observed in people with diabetes. Shoulder pain is found to be the most common symptom and can lead to hindrance in daily activities that can directly or indirectly influence the metabolic processes of our body affecting the quality of life. Hence, we studied the prevalence of shoulder pain and its functional limitations among patients with uncontrolled diabetes mellitus (DM).Materials: ...