Endocrine Abstracts

Case history: A 16 month old boy was referred to Community Paediatrics with developmental delay. Bloods taken as part of a developmental delay screen, revealed a raised calcium, with an inappropriately normal parathyroid hormone (PTH) and a normal vitamin D. There was no family history of hypercalcaemia. Blood tests in the boy’s mother and grandmother also showed hypercalcaemia.Investigations: Calcium was raised at 3.46 mmol/l. A urinary calcium cre...

We present a 67 years old male originally from Cyprus who presented with Hypercalcemia. He had renal calculi twice and required Laparoscopic procedure. In his family history his 3 siblings had confirmed raised calcium and PTH and 2 other siblings had renal calculi. One of his brother, had surgery for primary hyperparathyroidism twice but no parathyroid adenoma was found and his calcium remained high. Patients’ calcium was 2.81 mmol/l (2.15–2.50), 25 HVD 82 nmol/l (75...

Objective: Maxillofacial manifestations of acromegaly are well described (prognathism, inter-dental space enlargement, occlusion disorder, macroglossia, prominent cheekbones…) [1] but the dental and periodondal impact of this disease has been poorly investigated. The scientific literature on this topic is scarce, with controversies about gingival and cement enlargement. Our goal is to describe the oro-dental state of these patients as precisely as possible and to study t...

Management of Graves’ orbitopathy (GO) depends on the severity and activity of the disease. Guidelines for the management of GO have recently been published by EUGOGO (European Group on Graves’ Orbitopathy) (European Thyroid Journal 2016 5 9–26). Assessment of GO by standardized criteria is fundamental to determine the type of intervention. General measures for all patients with GO, irrespective of the degree of severity and activity, i...

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Primary Aldosteronism (PA), due to a unilateral aldosterone-producing adenoma of the adrenal (APA), is the commonest curable cause of Hypertension, but the prospects for cure fall with age. APAs rarely increase in size, suggesting an origin much earlier than the development of resistant hypertension. Most APAs have gain-of-function somatic mutations which result in increased Ca2+ entry, and constitutive activation of aldosterone production. Women with larger APAs, a...

Primary Aldosteronism (PA), due to a unilateral aldosterone-producing adenoma of the adrenal (APA), is the commonest curable cause of Hypertension, but the prospects for cure fall with age. APAs rarely increase in size, suggesting an origin much earlier than the development of resistant hypertension. Most APAs have gain-of-function somatic mutations which result in increased Ca2+ entry, and constitutive activation of aldosterone production. Women with larger APAs, a...

Background: Children with HbA1cs in target within the first year of diagnosis of diabetes show tracking of future results1 and experience fewer long term complications.2 This phenomenon is called ‘metabolic memory.3 HbA1C depends on a combination of patient factors and quality of care offered by the team (intensive insulin, communication, and support). We hypothesized that well managed, supported, patients should achieve target HbA1cs at l...

Introduction: It has been suggested that BMI, especially above 30, is associated with subfertility in men. At the same time validity of BMI to distinguish variability in body composition, have been questioned (MacDonald, 2010). In our study, we employed more accurate surrogate measures of adiposity to investigate the relations of semen parameters and reproductive hormones with waist circumference (WC) and waist-to-height ratio (WHtR).Methods: During 2010...

Case History: A 64-year-old gentleman presented with progressive exertional breathlessness since 1 year. He had started noticing pigmentation in the eyes 2 years back, and gave a history of passing black coloured urine since childhood. He had never consulted a medical professional for the same. Examination revealed hyperpigmentation of both ears and conjunctivae, and an ejection systolic murmur (Grade V) at the aortic area, which radiated to both his carotids. A sample of his ...