Endocrine Abstracts

Background: Glucocorticoid (GC) formulations are widely used as anti-inflammatory treatment, and synthetic GC, e.g. prednisolone, is the cornerstone treatment of polymyalgia rheumatic (PMR) and giant cell arteritis (GCA). Long-term pharmacological GC treatment may induce adrenal insufficiency (GIA). Adrenal function is, however, not routinely assessed after discontinuation of long-term GC treatment, and it is unknown, if hydrocortisone replacement is beneficial. This study aim...

Introduction: It is important to ensure the information shared on social media is up to date to current clinical practice, reliable and appropriate to the target audience. YouTube is the most popular social media platform for video-based medical information worldwide. You and Your Hormones is a UK-based website endorsed by Society for Endocrinology hosting videos on various medical conditions aimed at the public. CoMICs (Concise Medical Information Cines) are short videos prov...

Introduction: SGLT2 (sodium-glucose cotransporter 2) inhibitors are a molecule more and more used in type 2 diabetes. However, it can cause a metabolic decompensation in some cases. Euglycemic ketoacidosis may be atypical, misplacing and delaying the diagnosis. We investigated the precipitating factors of this metabolic complication in our case study and in the literature.Presentation of the Case: We report the case of a normal BMI (19 kg/m2) ...

Introduction: Benzold abscess remains rare, and its occurrence implies immunosuppression, particularly within unbalanced diabetes.Methods and Results: Observation of a 76-year-old patient, diabetic for 29 years, on metformin, admitted for CMO of the right ear, complicated by Bezold’s abscess. The interrogation revealed purulent otorrhea hypoacusis. The clinical examination revealed hyperglycemia, a swelling of the sternocleidomastoid, responsible fo...

Context: Acromegaly is associated with many complications, which affects multiple systems, such as cardiovascular, respiratory, metabolic, muscles and bones. Osteoporosis and osteoporosis fracture are commonly neglected comorbidity of this rare disease. Usual manifestation of this skeletal complication is skeletal fragility and vertebral fractures, but prior research confirms, that other location fractures can be found as well. Case illustration: We repo...

Hyponatremia is the most common disorder of electrolytes encountered in clinical practice, occurring in 15-30% of acutely or chronically hospitalized patients. Although many cases are mild and relatively asymptomatic, hyponatremia is nonetheless important clinically because: acute severe hyponatremia can cause substantial morbidity and mortality; overly rapid correction of chronic hyponatremia can cause severe neurological deficits and death. We present Clinical cases of endoc...

Introduction: The treatment of Graves’ disease is represented principally by anti-thyroid drugs, radioiodine ablation or thyroidectomy. Methimazole is the most used drug for the initial treatment. It is rare to encounter patients with resistant hyperthyroidism despite high doses of MMI.Case presentation: A 41-year-old woman was referred to our unit for resistant thyrotoxicosis. She had a confirmed Graves’ disease with positive serum Trab. Whils...

Introduction: Hypothyroidism can present in a variety of ways, from unexpected abnormal blood results in seemingly asymptomatic patients to those with a multitude of debilitating symptoms. Levothyroxine dose titration is a challenge often faced by physicians. We identified 8 difficult cases which following MDT discussion underwent the Thyroxine Absorption Test (TAT) to gain further clarification (Walker et al. 2013).Aim: To identify if the issue...

Introduction: Resistance to thyroid hormones (RTH) is a rare syndrome. This condition is caused by gene mutations of thyroid hormone receptors (THR). There are two types of genes that code THR: THR alpha (THRA) and THR beta (THRB). The RTH alpha is associated with mutations in the THRA gene and is less common than RTH beta [1]. It is challenging to identify patients with RTH alpha because usually they only have mildly abnormal (or even normal) thyroid hormone levels and the se...

Introduction: Primary hyperparathyroidism is associated with numerous cardiovascular complications including hypertension, left ventricular hypertrophy and calcification of cardiac valves. However, guidelines from expert panels and NICE have not included cardiovascular complications as an indication of parathyroidectomy. This literature review will be focused on benefits of parathyroidectomy on cardiovascular complications of primary hyperparathyroidism....