Endocrine Abstracts

Background: Conventional methods of one-way teaching may not involve the integration of clinical skills and may become more inefficient and passive [1]. During the COVID-19 pandemic, limited patient interaction and shift to online lectures greatly reduced the clinical exposure and opportunity of developing interpersonal skills for junior medical students. In this study, we hosted online webinars with case-based teaching for medical students so that they can amalgamate clinical...

Background and Aims: Cardiometabolic comorbidity is a well-established complication related to GH hypersecretion. Several studies have highlighted an increased cardiovascular risk in this population. The objective of the current work was to investigate the cardiovascular complications in Tunisian patients diagnosed with acromegaly.Patients and Method: We conducted a retrospective study that included all patients diagnosed with acromegaly who have been fo...

Introduction: The spectrum of corticotroph cell pituitary adenomas is very wide, silent corticotroph adenomas (SCAs) being a rare subtype with positive immunohistochemistry for adrenocorticotropic hormone (ACTH), without causing Cushing’s disease. SCAs may exhibit a more aggressive behavior, and the changing of the clinical phenotype towards Cushing’s disease is described. Case report: We present the case of a 74 years old, ex-smoker, hypertens...

Introduction: Type 1 diabetes mellitus (T1DM) is the result of the autoimmune destruction of beta-cells of the endocrine pancreas, leading to absolute insulin deficiency. The process of this autoimmune destruction occurs in genetically susceptible individuals with positive relevant autoantibodies. T1DM may be associated with other autoimmune diseases (AD) such as autoimmune thyroid disorders (AITD). Patients and methods: It is a descriptive retrospective...

Introduction: Liver function abnormalities in hyperthyroidism are common, several abnormalities have been reported: hepatic cytolysis, cholestasis, insufficiency or even non-specific abnormalities. The pathophysiology of hepatic dysfunction secondary to hyperthyroidism is not yet well established. Graves’ disease can be associated with various autoimmune diseases. However, association with Primary biliary cirrhosis has been described in few cases in literature. We report ...

Introduction: Thevenard’s disease is a sensory neuropathy with a type of ulcerative-mutilating acropathy of progressive course. It has a hereditary character with autosomal dominant inheritance. It is a scarce disease, which usually affects feet but can also affect hands. It causes disorders of thermoalgesic sensitivity, leading to painless ulcerations at the pressure points and then bone deformities with osteoarticular destruction and ‘cubic foot‘ appearance. R...

A 26 year old gentleman presented to his GP in July 2018 with a one month history of thyrotoxic symptoms, including palpitations and weight loss. His initial thyroid function tests (TFTs) showed a hyperthyroid picture, including a FT4 of >100pmol/l (RR 12-22). His TSH receptor antibody was 11.1 IU/l (RR <1.75). He had no evidence of thyroid eye disease, and no goitre or thyroid nodules on exam. His Graves” disease was initially managed medically with carbimazole. ...

Adrenocortical carcinomas (ACCs) are a group of aggressive neuroendocrine cancers that affect 1-2 people/million/year (1) and are mostly diagnosed in advanced stages. ACCs have poor overall survival (OS) rates (2). This study aimed to determine potential factors influencing OS of ACC patients in Yorkshire by a retrospective investigation of potential factors and OS of all 30 adult patients with ACC seen at St James University Hospital (SJUH) from 01/01/2000 to 01/10/2021. Anal...

Introduction: The triad of primary hypothyroidism, precocious puberty and delayed bone age in children with cystic ovarian enlargement constitutes the syndrome of van wyk grumbach. Commonly reported as a rare complication of hypothyroidism in children, there are only a few case reports in adult population. Herewith, we are reporting the case of a 22-year-old hypothyroid lady, who presented with bilateral ovarian cysts. Considering hypothyroidism, a high risk for surgery, thyro...

Background: Ectopic malignancies arising from adrenal rests are extremely rare. Localization has been reported in the retroperitoneum, testis/scrotum, ovary, kidney, anterior abdominal wall, spinal cord, and liver associated with embryological development 1-3.Objective: This report presents a case of ectopic adrenocortical cancer (ACC) localized to the pancreas. An exciting feature of the case was the simultaneous presence of breast cancer.</p...