Endocrine Abstracts

Ramadan is a holy month in the Muslim religion, it involves a period of daily fasting from sunrise to sunset, which means an average of fifteen hours of fasting during the day (twelve to eighteen hours depending on seasons and regions). In diabetics, this involves metabolic disorders related to fasting, food mode (quantitative and qualitative change in dietary intake). The objective of our study is to define the profile of diabetic patients seen in the emergency department and...

Introduction: Ophthalmopathy is the most common extrathyroidal manifestation of Grave’s disease, with 3–7% evolving to Dysthyroid Optic Neuropathy (DON), which requires urgent treatment to avoid permanent or progressive visual loss. We describe two cases of DON evaluated at Endocrinology and Metabolism Service of Paraná (SEMPR).Case 1: Male, 70 years old, previously diagnosed with hypertension, type 2 diabetes with insulin use, microvascul...

Introduction: During nephrotic syndromes, thyroid function abnormalities may be observed. Hypothyroidism due to loss of thyroid hormones or their binding proteins can be seen but remains a rare complication of nephrotic syndrome. We report the case of 22 year old patient admitted for massive proteinura with nephrotic syndrome that was complicated with hypothyroidism.Case report: We report the case of 22 year old patient who presented with generalized ede...

Background and Aims: Obesity is a major risk factor for type 2 diabetes (T2D). Remission of diabetes can be achieved by dietary weight loss although the underlying molecular mechanism(s) are unknown. These beneficial effects could be related to decreasing hepatic fat delivery to the pancreas and eventually restoring β-cell function. We hypothesised that hepatic de novo lipogenesis (DNL) is the primary driver of pancreas “lipotoxicity” and the pr...

Several pathological processes contribute to the development and progression of pulmonary arterial hypertension (PAH), which is a disorder with high morbidity and mortality rates. However, although cardiac manifestations are common in hyperthyroidism (HT), they have been seldom described in association with HT. Thus, the objective of this study was to evaluate echocardiographic parameters in patients with Graves Disease (GD) during uncontrolled hyperthyroidism and after its re...

Introduction: Hypophosphatemic rickets comprehends a group of hereditary diseases characterized by hypophosphatemia and defective bone mineralization. The most common form is X-linked, with a prevalence of 1:20.000.Objectives: Describe the follow up of patients with hypophosphatemic rickets in a public center in Brazil.Methods: Patients with hypophosphatemic rickets were selected from a database of Endocrinology and Metabolism Serv...

Introduction: The availability of the body’s most abundant amino acid, glutamine is compromised in obesity-associated diabetes. This may impair glucose metabolism by increasing hepatic insulin resistance, oxidative stress and the development of nonalcoholic fatty liver disease (NAFLD).Objective: Evaluate the effects of free and dipeptide (DIP, L-alanyl-L-glutamine) forms of L-glutamine on glucose metaboli...

Context: Sodium-glucose cotransporter 2 (SGLT2) inhibitors induce glycosuria and improve glycemic control, β cell function and insulin sensitivity in type 2 diabetes mellitus (DM2). On the other hand, these drugs predispose to diabetic ketoacidosis by increasing the tonus of glucagon. Glucagon acts on the liver and has no relevant effect on peripheral lipolysis and release of free fatty acids (FFA) as a substrate for ketogenesis, an action attributed to growth hormone (GH...

Introduction: There is some variation in the practice of gonadectomy for individuals with Differences of Sex Development (DSD) worldwide. This quality improvement project aims to undertake continued surveillance of the occurrence of gonadectomy in suspected or confirmed cases of DSD.Methods: Participating centres from the International-DSD Registry are sent a monthly email asking if a gonadectomy has been performed. A se...

Steve Shalet, Dept of Endocrinology, Christie Hospital, Manchester, UK AbstractAfter completing a BSc in Physiology at London University in 1966, I qualified in medicine at the Royal London Hospital in 1969. Junior hospital medical training posts in London and Bristol were followed by an appointment as Research Fellow in Endocrinology at the Christie Hospital, Manchester in 1974....