Endocrine Abstracts

Aim: To study features of neuroendocrine, hormonal and ophthalmic complications of giant pituitary adenomas depending on the volume and growth of the tumor (data from a prospective study).Material and methods: Us for the period from 2020 to 2022. 151 patients with macro- and giant NFPA were prospectively examined. According to the size of pituitary adenomas, patients of prospective (151 patients) observation were divided into 2 groups: group 1 – pat...

Introduction: Although a number of studies have reported on the External Masculinisation Score (EMS) and have validated its use for numerical descriptions of the external genitalia, the methodology in these studies has not considered longitudinal changes in EMS.Objectives: To examine longitudinal changes in EMS in boys with XY Disorders of Sex Development (DSD) and determine the causes of these changes.Methods: All boys of confirme...

Goal: To carry out a retrospective analysis of case histories of children and adolescents with genetically determined types of short stature who admitted a paediatric department of a clinic of Research Institute of Endocrinologyduring 2003–2013.Materials and methods: An analysis of case histories of children and adolescents with short stature 3 to 17 years who undertook inpatient treatment in paediatric department of RIE clinic during 2003–2013...

Goal: Identification of latent mosaicism and determination of a parental origin of an X chromosome in TS patients in Uzbek population.Methods: Molecular genetic studies are carried out in 35 patients with TS (26 with monosomy and nine with mosaicism) at the age of 7–16 and their parents with a set of DIATOMTMDNA prep 200 reagents. DNA amplification was performed in Applied Biosystems thermocyclers. PCR products were subjected to electrophoresis on 1...

Introduction: Autoimmune polyglandular syndrome (APS) is a group of polyendocrinopathies characterizedby multiple glands insufficiencies associated with other autoimmune diseases resulting from immune mediated destruction. We describe a patient with type 2 APS presenting first with diabetes type 1 followed later by adrenal insufficiency and Hashimoto disease.Case report: A 23-year-old male, known with diabetes type 1, presented with a very low blood pres...

Introduction: Ectopic Cushing’s syndrome (ECS) is a rare disease caused by ACTH secretion by extrapituitary neuroendocrine tumors, characterized by high mortality. Despite the clinical sings of Cushing’s syndrome, difficult access to reliable clinical examinations, leads to a delay in diagnosis and the choice of optimal treatment tactics. Small-cell lung cancer patients with ECS have a very poor prognosis. Case report: A 35-year-old woman ...

The purpose of the study: Is to study the efficiency of the treatment by Sandostatin-Lar in patients with non-functional pituitary macroadenomas (NFPA) Material and methods.: Under our observation there were 20 patients with NFPA, of whom women were 8, men - 12. The average age of patients was 29,2/36.4 years. All patients were subjected to transnasal adenomectomy of pituitary gland (TAG) in our clinic. The whole patients were performed by research compl...

Introduction: Cervical thymic cysts are among the rarest congenital neck masses. Thymic migration into the superior mediastinum during organogenesis explains the topography and diversity of clinical presentations of these cysts. Due to the possibility of mediastinal extension, the management of these lesions is different than other congenital neck masses. The aim of our work is to present the clinical, radiological, and therapeutic features of cervicomediastinal thymic cysts.<...

In this study, we attempted to assess the toxicity of Methyl Thiophanate (MT) on the biochemical and reproductive parameters in male Wistar rats as well as the possible protective role of Zingiber officinale (Ginger, Ging) extract against MT-induced toxicity. Hence, forty adult Wistar rats were allocated into four groups of 10 rats for each; the first group served as control, groups 2, 3 and 4 were treated orally (5/week) for 8 weeks by MT (150 mg/kg bw), Ging (100 mg...

Introduction: Patients with clinical clues suggesting the possible presence of secondary hypertension should undergo a more extensive evaluation, because in this case some of these disorders can be cured, leading to partial or complete normalization of the blood pressure.Case description: We report a case of a 43-year-old man, who suffered for years of hypertension despite concurrent use of adequate doses of three antihypertensive agents from different c...