Endocrine Abstracts

Objective: Therapeutic options for patients with dedifferentiated thyroid carcinoma are rare and alternative treatment strategies are needed. Among the most promising new agents for these patients are protein kinase inhibitors like the BRAF- and multi-targeted kinase inhibitor sorafenib. We have already shown that sorafenib inhibits growth of dedifferentiated thyroid carcinoma cell lines with and without BRAF mutation. The purpose of this study was to analyze the molecular eff...

Introduction: Acromegaly is characterized by high cardiovascular morbidity and mortality possibly due to increased prevalence of main traditional cardiovascular risk factors. It is not clear though whether the incidence of atherosclerosis is truly enhanced. Moreover recent in vitro studies show a protective role of (GH) and IGF1 (insulin-like growth factor-1) on the endothelium. As expression of endothelial regenerative reserve, endothelial progenitor cells (EPCs) could...

There is evidence for a strong association between Cushing’s syndrome, characterized by a cluster of systemic complications, and increased cardiovascular risk. To our knowledge, coronary circulatory function has not been explored in Cushing’s syndrome. The aim of the study was to evaluate coronary flow reserve (CFR), an index of coronary microvascular function, in patients with Cushing’s syndrome. Thirteen newly diagnosed patients with Cushing’s syndrome (1...

Introduction: Achievement of stable normocalcemia (88–98.8%) is considered a criterium of efficiency of surgical operations for primary hyperparathyroidism (PHPT) (P.Goudet et al. 2001, Zeiger 1997). In 1–15% of cases, persistence of PHPT is noted (Mariani et al. 2003, Mariette et al. 1998).Description of methods: In 110 of 175 patients (aged 14–72 years), parathyroid adenoma was verified, in 57 – hyperplasi...

Active acromegaly is associated with significant comorbidity and reduced quality of life. Cross-sectional studies have shown that quality of life did not significantly change in long-term cured acromegalic patients. However, the effect of medical treatment on the quality of life in the short term is unknown.We evaluated the quality of life by a disease-specific questionnaire in a longitudinal study before and after a 6-month course with somatostatin anal...

Exon 1 of AR gene contains a variable number of CAG triplets, which encode a polyglutamine stretch of variable length in the N-terminal domain of the receptor. Experimental evidence has accumulated in demonstrating that the length of this stretch influences AR transcriptional activity and therefore modulates target organs responsiveness to androgens. Aim of our study was to evaluate CAG repeats length [(CAGr)n] in various conditions hypothetically influenced by AR function. 35...

Polycystic ovarian syndrome presents in 4–8% of women worldwide, making it the most common reproductive age endocrinopathy. Rheumatological concomitant diseases are extremely rare in PCOS patients, especially Raynaud’s phenomenon. Condition that, lowers the quality of life in patients, suggesting hormonal imbalances despite years of treatment. Studies show that oestrogen plays a role in the vasculature, it is exogenous administration increases the endothelium depende...

Objective: Osteoporosis is a typical long-term complication after solid organ transplantation. Patients after simultaneous pancreas kidney transplantation (SPK) are at a very high risk due to preceding renal osteopathy and diabetic status. To determine the best preventive strategy we analysed the bone metabolism at the point of the pretransplant examination.Design and methods: In years 2011–2014 the number of 112 patients with type 1 diabetes (69 me...

Introduction: Agranulocytosis represents a serious complication of thyreostatic (ATD) treatment. The aim of our work was to determine how often did agranulocytosis occur in Graves’ disease patients admitted to the thyroid treatment department of our clinic for RAI treatment between the years 1999 and 2014.Patients and methods: We have retrospectively analysed 699 patients (572 women and 127 men at the average age of 51.5±12.9 years). 327 (47%) ...

Introduction: The early management of atypical genitalia has been highlighted as being of critical importance by the UK-DSD guidance in 2011.Objectives: To estimate the incidence of atypical genitalia requiring early specialist input in neonates and its clinical presentation and management.Method: Prospective audit through the Scottish DSD network and the Scottish Paediatric Endocrine Group, between June 2013 and June 2014. Monthly...