Endocrine Abstracts

Background and Aims: The metabolic-associated fatty liver disease (MAFLD) is a fatty liver accumulation with metabolic dysfunction (diabetes, overweight/obese, insulin-resistance), a definition more practical for identifying patients with fatty liver disease with high risk of disease progression. The triglyceride-glucose (TyG) index is a marker of insulin resistance. Long-term fasting plasma glucose (FPG) variability is associated with fatty liver content (FLC). Continuous glu...

Introduction: Patients with hypoparathyroidism (hypoPT) suffer from a number of complaints and reduced quality of life (QoL) besides having serum values for disease-specific parameters in the target range. To be able to quantify symptoms in hypoPT patients we lately developed a disease-specific questionnaire, the Hypoparathyroidism patient questionnaire with 28 items (HPQ28). The aim of this study was to present normative values for the HPQ28.Methods: A ...

Introduction: An undefined lesion detected by imaging methods in one or both adrenals is known as an incidentaloma. The size and capacity of the secretion are evaluated to determine its definitive management. It is extremely uncommon for a mixed adrenal incidentaloma to appear with elevated cortisol and medullar hormone output.Case report: A 21-year-old woman was admitted to the hospital with intermittent palpitations, headaches, and chest pain. She was ...

Introduction: Despite basal-bolus regime many type 2 diabetic patients do not achieve good glycemic control. Obesity and a large number of insulin units per day, even in combination with metformin and/or SGLT-2 inhibitors, are challenge in treatment of those patients.Aim: To assess changes of glycemia, body weight and daily dose of insulin in a group of type 2 diabetic patients treated with basal-bolus scheme (with/without peroral agents), starting with ...

3-Iodothyronamine (T1AM) is a hormone like molecule structurally similar to TH, that has been reported to modulate energy metabolism by favoring lipid over glucose catabolism. To better understand the role played by T1AM on the regulation of lipid metabolism, in the present study we administered spontaneously obese mice with T1AM at two different dosages (10 and 25 mg/kg per day) for 7 days and the effects on body weight (BW) and lipid profiles were examined. In addition a flu...

Introduction: Patients with diabetes (DM) are at increased risk for cardiovacular disease (CVD). Possible effects of insulin therapy on development of atherosclerosis and CVD were studied.Patients and methods: Relevant metabolic parameters were determined in 348 patients assigned into groups with DM2 on oral hypoglycemic drugs (DM2-OH) and insulin (DM2-INS), and with DM1.Results: A significant among-group difference was found in ad...

The myokine irisin is secreted after cleavage of the transmembrane protein Fibronectin type III domain-containing protein five and was shown to induce a thermogenic program in white adipose tissue. This cleavage can be induced by exercise, thus linking exercise with browning of adipose tissue. We investigated the response of Fndc5/irisin as well as its inducer Peroxisome proliferator-activated receptor gamma co-activator 1α (Ppargc1a) in mice long-term selected for high t...

Human and animal health has been exposed to endocrine disruptors (EDs) which are chemicals found in pesticides, food or personal care products. The main concern about these disruptors is caused by their interference with the endocrine system causing adverse effects, such as altered reproduction, abnormal neurological development in newborns and children or an elevated susceptibility to hormone-related cancers. The thyroid gland and its hormones belong to major targets that are...

Objective: Recent papers reported that basal calcitonin (CT) level may be related to thyroid volume. This study aims to evaluate if this finding is confirmed in patients undergoing ultrasonography-guided fine-needle aspiration cytology (FNAC) for thyroid nodules.Design: Retrospective university-center study.Methods: From February 2010 to September 2012, 561 patients underwent ultrasonography-guided FNAC and a complete evaluation in...

Background: The Scottish Genital Anomaly Network(SGAN) is a national managed clinical network that provides care to patients with a suspected disorder of sex development(DSD). Factors that influence the decision to perform a karyotype in suspected DSD are unclear.Aim: To explore the SGAN register to study the factors that influence the decision to perform a karyotype. Variables examined included centre of presentation, examination findings and associated...