Endocrine Abstracts

Risk factors involved in new-onset diabetes mellitus after transplantation (NODAT) remain unclear. Clinical studies have demonstrated the association between low vitamin D levels with insulin resistance and diabetes. In animal models, osteocalcin deficiency leads to high glucose levels and insulin resistance.The aim of this study is to evaluate the prevalence of NODAT and other alterations of glucose metabolism after liver transplantation (LT) at our ins...

Introduction: Renal function and glucose lowering therapy, particularly metformin, influence serum lactate concentration in patients with type 2 diabetes (T2D). However, seems to be an acute precipitating event that triggers hyperlactacidemia and metabolic acidosis. This study aims to assess prevalence of hyperlactacidemia in T2D patients who presented at emergency room (ER), calculate relative risk of hyperlactacidemia in diabetics under metformin, identify predictive factors...

Introduction: The discovery of incidental thyroid carcinomas (ITC) in patients undergoing surgery for a benign disease range between 3 and 16% of cases. During years, patients with hyperthyroidism were considered protected by TSH suppression (TSH is well known factor that favors the development of thyroid cancer). Thyroid size might be a predictive factor due to the excess of thyroid tissue prone to mutations. The knowledge of determining factors foretelling the presence of un...

IntroductionNeurofibromatosis type 1 (NF-1) is a relatively frequent syndrome, with an estimated incidence of 1/3000 per year. Patients with NF-1 are at an approximately fourfold higher risk of developing tumors than the general population, most frequently gastrointestinal stromal tumors, central nervous system tumors and endocrine tumors. Pheochromocytoma may occur in about 1% of these patients.Case report: We report a 56-year-old...

Background: Pendred syndrome (PS) is an autosomal recessive disorder characterized by defective organification of iodine, goiter and deafness. It is caused by mutations in pendrin gene (SLC26A4), a transporter of chloride/iodide that mediates the efflux of iodine from thyroid follicular cells to the follicular lumen.Clinical case: Case-index: MJFS, female, refered to consultation at 35 years for enlarged neck. Personal history: congenital deafness, thyro...

Introduction: Thymic hyperplasia has been described after hypercortisolism resolution. The natural history remains poorly defined: emergence ≧1 month after hypercortisolism resolution, variable duration, usually spontaneous resolution/benign course.Case Report: ♂, 24, referred in 2000 for secondary hypothyroidism: TSH: 0.25 μUI/ml (0.25–5); FT4: 5.55 pmol/l (9–20). Clinical evaluation: insomnia, nocturnal sweating, facial eryt...

Introduction: Acromegaly is a rare disease with a high morbidity and mortality rate.Our aim was to characterise the population with acromegaly that is currently under supervision at our Department.Materials and methods: We included 104 patients with acromegaly (mean age at the diagnosis 44.0±13.0; with 71.2% females).The referred population was analysed on what concerns disease’s duration, clinical ...

Introduction: The differential diagnosis of nonpituitary sellar masses is broad. Clinical presentation may be similar to that of pituitary adenomas. Sometimes certain findings are particular to some lesions and may help in their differentiation. Correct preoperative diagnosis is important to better guide therapeutic management. The aim of this work was to analyze patients with parasellar lesions (craniopharyngiomas excluded), attended in the Department of Endocrinology of our ...

Current guidelines recommend measurement of rhTSH-stimulated Tg, with neck ultrasound 6–12 months after the initial therapy for DTC (Total thyroidectomy plus 100 mCiI131 ablation of the thyroid bed). Uncertainty persists regarding whether the subsequent follow up should be based on measurement of basal serum Tg or whether rhTSH-stimulated Tg should be performed and at what frequency. The aim of our study was to evaluate the utility of repeated rhTSH-stimulated Tg.<p c...

Increasing incidence of papillary thyroid microcarcinoma (PTMC) is due to accurate histological study of surgical specimens (incidental, INC) or to improved preoperative diagnostic techniques (preoperatively diagnosed, PD). We evaluate the differences between both groups of PTMC from 2000 to 2009.We reviewed data of patients diagnosed of PTMC (<10 mm) during the last decade with complete follow-up since surgery. Demographic data, tumour size, histolo...