Endocrine Abstracts

Objective: Flash glucose monitoring (FGM) allows non-invasive glucose level assessment. Our objective was to describe the characteristics of patients in a secondary referral hospital and their glycemic control expressed as FGM targets.Methods and patientsObservational longitudinal clinical study between January 2021 and December 2021 in patients with DM1 referred to a secondary care center in Montilla (Córdoba).Results: 101 patients included. Mean a...

Introduction: Thyrotoxic crisis is a rare endocrinological emergency with high mortality and it is more frequent in Graves’ disease.Clinical case: A 66-year-old women with schizophrenia was admitted to the Emergency Department due to altered state of consciousness, fatigue, constant moaning interspersed with unusual psychomotor agitation, heteroaggressiveness, diarrhea and anorexia. Lack of compliance with her psychiatric medication, new delusional ...

Introduction: T2DM is one of the main causes of morbidity and mortality in the UK. Epigenetic mechanisms impact gene expression and could predispose individuals to a particular metabolic phenotype. We investigated association of LINE-1 methylation (a surrogate of global DNA methylation) with cardiometabolic parameters in a longitudinal cohort of T2DM patients.Methods: Global LINE-1 DNA methylation in blood-derived DNA samples from 795 (men 60%, women 40%...

Introduction: T2DM is one of the main causes of morbidity and mortality in the UK. Epigenetic mechanisms impact gene expression and could predispose individuals to a particular metabolic phenotype. We investigated association of LINE-1 methylation (a surrogate of global DNA methylation) with cardiometabolic parameters in a longitudinal cohort of T2DM patients.Methods: Global LINE-1 DNA methylation in blood-derived DNA samples from 795 (men 60%, women 40%...

Objective: The carbohydrate metabolism dysfunctions are common in critical ill patients with diabetes or stress hyperglycaemia and the correct management of them has an important prognostic value. Despite its limitations, capillary glucose (CG) was collected more than arterial glucose (gold standard) because of its good correlation. However, the usefulness of intermittent intersticial glucose monitoring (IGM) in keeping blood glucose within target range in critical ill patient...

Central pontine myelinolysis (CPM) is a neurological disorder typically caused by rapid correction of severe chronic hyponatremia. Conditions causing a hyperosmolar state can also cause CPM, but it is rarely seen in diabetes. We report the case of a 33-year-old woman with personal history of Type 1 Diabetes since she was 9 years old with very poor metabolic control (A1hbC 15%) and microvascular complications, who attended the emergency department due to left hemicranial headac...

Primary generalized glucocorticoid resistance or Chrousos syndrome is a rare disorder, which affects all tissues expressing the human glucocorticoid receptor. It has been defined by an absence of overt Cushing’s syndrome (CS) signs (no skin weakness, muscle atrophy, or osteoporosis) associated with biological hypercortisolism consisting of high urinary free cortisol (UFC) and an absence of negative feedback loop of cortisol on HPA, defined as 8-AM cortisol level >50 n...

Introduction: The anatomical and physiological changes induced by bariatric surgery (BS) can significantly impact the absorption and pharmacokinetics of orally administered medication. In particular, levothyroxine (LT4) dosage, given its dependence on patient’s weight and gastric pH for optimal absorption, is expected to change following BS. However, the literature is not unanimous and there is a void of longer-term studies. We aimed to compare LT4 dosage 4 years followin...

We report the case of a 34-year-old woman with a personal history of type 1 diabetes mellitus (DM1) since she was 9 years old. Very poor chronic metabolic control stands out despite multiple insulin schemes with multiple complications: nephropathy, retinopathy and peripheral neuropathy. She was admitted to the hospitalization floor due to diabetic ketoacidosis. At admission Hba1c of 15.3%. During admission after treatment with IV insulin, improvement in glycemic control. Nine ...

Purpose: To establish the safety and efficacy of multikinase inhibitors (MKIs) treatment in real life.Methods: This retrospective observational descriptive study included patients with advanced differentiated thyroid cancer in treatment with MKIs as first and second line treatment. From November 2011 to May 2022. Clinical variables, efficacy and adverse events (AE) were collected. Variables are expressed as median and interquartile range.<p class="ab...