Endocrine Abstracts

Introduction: Recent studies defend the measurements of insulin resistance and β-cell function to assess the endocrine pancreatic function in patients with cystic fibrosis (CF). HOMA-IR indexes greater than 1 translate insulin resistance and HOMA-%β values lower than 100% imply an altered β-cell function.Aim: To describe insulin resistance and β-cell function using HOMA-IR and HOMA-%β indexes in patients with CF and compare them ...

Introduction: Fine-needle aspiration (FNA) is indicated in suspicious thyroid nodules or big ones. Bethesda system classifies them according to the cytological malignancy risk. Bethesda category 4 (B4) comprises follicular neoplasms and suspicious follicular neoplasms. Aim: Determine final diagnosis of B4 nodules and study associations between malignancy and other variables.Methods: Retrospective study of patients with nodules classified as B4 a...

ObjectiveHealth care for transsexuals has changed in Andalucia since 2014. Our unit of attention to transsexual people began in 2015. The objective of this study is to analyze our experience.Patients and methodsRetrospective study by reviewing the medical records of the transsexuals treated in our unit.Results145 transsexual people. Transsexual man to woman (TMW):...

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a relatively recent and rare disease, frequently misdiagnosed. It is characterized as a generalized proliferation of pulmonary neuroendocrine cells and is recognized as a precursor lesion for pulmonary neuroendocrine tumors, although the risk of progression to malignancy is considered low. Here we report a patient with ectopic ACTH-dependent Cushing’s syndrome due to metastatic lung carcinoid tumors...

Background: Thyroglobulin (Tg) is a promising biomarker for monitoring iodine nutrition in children and pregnant women. The determination of Tg in dried blood spots (DBS) offers many logistical advantages, simplifying the collection, transport, and storage of samples. The present study aimed to validate an ELISA assay for Tg determination in newborns.Methods: Tg-DBS samples were measured in 196 newborns born from healthy pregnant women. The different cri...

Aim of the work: The effects of subclinical hyperthyroidism (SCH) on bone and heart have been well documented. Effects on other parameters like lipids metabolism and weight regulation have also been reported but mainly in cross-sectional studies. The potential benefits of treatment of endogenous subclinical hyperthyroidism are more controversial as few large controlled studies on clinical outcomes have been performed. ATA guidelines recommend treatment according to the severit...

Introduction: Children with TPS and/or ICDI represent a diagnostic and management conundrum. Agreed radiological criteria for TPS are lacking.Aims: To longitudinally characterize the neuroradiological features of children presenting with TPS and/or ICDI due to different aetiologies (oncological, inflammatory, idiopathic).Methods: We searched the terms ‘thickened pituitary stalk’ or ‘idiopathic diabetes insipidus&#146...

Adrenal venous sampling (AVS) is regarded as the gold-standard for the study of lateralisation of primary aldosteronism (PA) after its biochemical diagnosis. After catheterisation of both adrenal veins, confirmed by ratio of cortisol concentration in each adrenal vein and peripheral vein (selectivity index (SI)), lateralization is accepted if aldosterone/cortisol (A/C) ratio between both adrenal veins is over 3–4 (lateralization index (LI)), particularly if non-dominant v...

IntroductionThe malignancy risk of an adrenal nodule is based on clinical symptoms (rapid onset of hypercortisolism and hyperandrogenism; mass symptoms) and imaging characteristics. These suspicious criteria include boundary irregularities, heterogeneity, dimension>6 cm and density>20 HU (CT). However, these are not absolute criteria.Case reportWe report the case of a 43 years-old female patient with a histor...

Background: Thyroglobulin (Tg) is a promising index of iodine status in pregnant women and children. The present study aimed to test a new strategy facilitating the monitoring of iodine status using Tg dried blood spot (DBS) in newborns.Methods: Pregnant women were recruited in the third trimester of pregnancy at the Erasme Hospital in Brussels, Belgium. Thyroglobuline concentrations and urine iodine concentrations (UIC) were determined in pregnant women...