Endocrine Abstracts

Objectives: To describe the prevalence of liver steatosis in a cohort of patients with Cushing’s disease.Methods: Cross-sectional descriptive study. We included 59 patients with Cushing’s disease from our cohort of patients who underwent a Fibroscan to analyze the degree of hepatic steatosis (CAP measured in dB/m) and liver fibrosis (fibrosis measured in kPa). Biochemical algorithms of liver steatosis and fibrosis were assessed.<p class="ab...

Aim: To describe the prevalence of abnormal glucose tolerance and diabetes in patients with cystic fibrosis (CF) depending on the diagnostic criteria.Methods: Observational, cross-sectional, clinical research on patients with CF evaluated at Hospital Universitario Reina Sofía (Córdoba).Results: Twenty-eight patients were selected for the study. Age: 31.85±8.78 years, with a CF evolution time of 21.77±9.37 years....

Objetive: Evaluate the efficacy of subcutaneous HCG with or without FSH in male infertility associated to hypogonadotropic hypogonadism (HH).Patients and methods: Descriptive study of patients with HH treated with HCG s.c. with or without FSH, for fertility objective (2004–2011). The Treatment was initiated with HCG 500 UI/72 h s.c., periodic monitoring of testosterone and semen analysis was realized, adjusting doses up to 2500 UI/72 h. If no answer...

Background: Pituitary adenomas represent a commonly underestimated pathology in terms of incidence and associated morbimortality. Additionally, some patients poorly respond or develop resistance to current medical treatments [i.e. somatostatin analogues (SSAs) and dopamine agonists]. In this context, it is necessary to develop novel and/or optimize currently available medical therapies. Biguanides (metformin, buformin and phenformin) are antidiabetic drugs that have been descr...

IntroductionCushing’s disease is the result of prolonged exposure to excess cortisol caused by a pituitary tumor, known as corticotropinoma, which hypersecretes adrenocorticotropin (ACTH). Treatment with somatostatin analogs (SSA) has been shown to reduce hormone secretion and, to a lower extent, tumor growth in some subtypes of pituitary tumors, such as growth hormone secreting tumors. However, SSA are commonly ineffective in corticotropinomas. Pre...

Background: Cushing’s disease is the result of prolonged and excessive exposure to cortisol caused by a pituitary tumor. Treatment with somatostatin analogs (SSA), which can reduce hormone secretion and tumor growth in other pituitary tumors (e.g., somatotropinomas), is usually ineffective in corticotropinomas. Previous studies indicated that presence of the truncated SST5TMD4 receptor variant is associated with a lack of response to SSA in acromegaly; but, its presence a...

Objective and methods: Recent studies suggest that altered alternative splicing and, consequently, appearance of an abnormal splicing pattern and even of aberrant/oncogenic splicing-variants, represent a common molecular feature of most tumor pathologies, including Pituitary Neuroendocrine Tumors (PitNETs). However, the putative alteration, pathophysiological role and potential therapeutic utility of splicing machinery components [i.e. spliceosome-components (SCs) and splicing...

Introduction: Hydrocarbon Alteration (HA) is considered as the most common complication in Cystic Fibrosis (CF) and is related to a further deterioration of the lung function and the nutritional status.Objective: Analyze the prevalence of HA in patients with CF in an adult unit and its relationship with pulmonary complications.Material and methods: We conducted a retrospective study with 71 patients of our CF unit (age 30+/−9...

Non-functioning pituitary-adenomas (NFPAs) represent the most common pituitary tumor-type. To date, there are not clinical, biochemical, anatomo-pathological, immuno-histochemical or molecular parameters useful to predict their remission. Therefore, the aim of this study was to evaluate the potential relationship between the clinical, biochemical and pathological characteristics of patients with NFPAs, the expression profile of these tumours and the clinical outcomes during th...

Pituitary adenomas (PA) comprise a commonly underestimated pathology in terms of incidence and associated morbimortality. To date, somatostatin and dopamine analogs represent the main medical treatment, but an appreciable subset of patients are resistant or poorly responsive to these drugs. Therefore, the search for new approaches to control tumor growth and/or hormone secretion is crucial. Biguanides such as metformin (MF; commonly used to treat type-2 diabetes), phenformin (...