Endocrine Abstracts

Introduction: Maternally-inherited diabetes with deafness (MIDD) is a rare form of monogenetic diabetes caused by a point mutation in mitochondrial DNA at a position 3243A>G. The syndrome is characterised by diabetes and sensoneural hearing impairment. Additional clinical features include short stature, cardiomyopathy, myopathy, renal disease, macular dystrophy, and gastrointestinal disease. The majority of patients usually require insulin therapy within 2 years and metfor...

Introduction: Topical wound oxygen therapy (TWO2) is therapeutic modality that delivers humidified pressurised O2 directly to the specific body part to achieve tissue penetration and increased O2 levels to the open ischaemia wound. O2 is vital in the synthesis of collagen, enhancement of fibroblasts, angiogenesis, leukocyte function, energy metabolism, and the inhibition of mycrobial growth. TWO2 therapy has showed effecti...

The aim of the study was to compare ATPIII and IDF criteria for metabolic syndrome in diabetes mellitus type 2 subjects.Two hundred and seventy-seven participants were included, 177 women 60.43±8.06 years and 100 men aged 56.35±9.58 years. Group A: metabolic syndrome by ATPIII; group B metabolic syndrome by IDF.Following laboratory and antropometric measurements were done: total cholesterol, triglycerides, LDL- and HDL ch...

Background and Aims: The aim of our investigation was to evaluate the relationship between parameters of the metabolic syndroma (MSDR; NCEP/ATPIII Panel) in randomly selected diabetic patients (DM) with peripheral arterial occlusive disease (PAOD).Materials and Methods: diabetics, male 680 (49.7%), age (mean+SD) 52.6+14.4yrs. (16–84), were propectively examined using doppler examination and neuropathy disability scoring (NDS). PAOD was confirmed in ...

Introduction and objective: Cardiovascular mortality is high in acromegaly. Our aim in this study was to determine the levels of the new cardiovascular marker in active acromegaly patients, the mean platelet volume (MPV) values before and after octreotide acetate LAR treatment.Material and methods: Thirty-six patients with active acromegaly who presented at the endocrinology department (mean age 46.0±14.0 years and mean BMI: 30.4±5.1 kg/m2...

Introduction: It is known that diabetes mellitus and its complex yet insufficiently known mechanisms affect bone strength and increases the fracture risk.Objective: The aim of this study was to assess bone mass measured by lumbar spine and hip DXA, in patients suffering from diabetes mellitus according to sex and type of diabetes.Material and methods: It was a prospective study. Included 150 diabetic patients of both sexes.<p c...

Introduction: Biological casuses of levothyroxine (LT4) malabsorption are well known. Congestive heart failure, gastrointestinal diseases, pregnancy, medication or dietary interference are the most commonly known causes of poor oral absorption of LT4. However, when substitution therapy with LT4 fails we need to be more exploratory.Case description: Female, born in 1987, BH 164 cm, BW 73kg, in 2010 she was presented as M. Basedowi and in october 2011 near...

Introduction: Congentital adrenal hyperplasia (CAH) comes to adult endocrinologist wheather as transition from pediatritian (Case 3) or as still without diagnosis (Case 1, 2, 4). The aim of this work is to describe typical forms of CAH initially sucessfuly treated with dexamethasone therapy.Case descriptions: Case 1: female, 1972y., presented in 1995y. (23y.) as severe hirsutism and infertility managed by team of gynecologists. She refus...

Introduction: It is indisputable importance of vitamin D for the preserved integrity of the skeleton and bone metabolism.The aim of the study was to analyse bone turnover parameters in relation to the vitamin D status in women with postmenopausal osteoporosis.Materials and methods: This study included a total of 195 postmenopausal women with osteoporosis. Osteoporosis is diagnosed by DXA scan of the spine and hip. Bone turnover mar...

Introduction: Literature data suggests increased fracture risk in women with diabetes mellitus type 2 but the underlying mechanism is not fully understood.Aim of the study was to analyse bone turnover parameters in women with DM2 and in healthy women with osteoporosis in menopause.Materials and methods: There were 76 participants out of wich 36 women with DM2. Average diabetes duration was 14.48±10.51 years with mean HbA1c 7.8...