Endocrine Abstracts

Lipoprotein-associated phospholipase A2 (LpPLA2) is a member of the phospholipaseA2 super family of enzymes, and is upregulated in arterial inflammation, obesity and cardiovascular disease. The other isoforms, iPLA2 and cPLA2, appear to contribute to inflammation through production of lipid mediators. The role of PLA2 in human adipose tissue (AT) is unclear, therefore we sought to i) characterise PLA2 isoforms in lean, obese, T2DM abdominal subcutaneous (AbdSc) and omental (Om...

Background: Previous genome wide association studies in Caucasian and South Asian populations have identified over 35 loci for type 2 diabetes mellitus (T2DM) risk. However, little is known about the contribution of these loci in T2DM from a Saudi Arabian population. In this study we investigated for the first time, the association of 38 previously identified T2DM risk loci (32 loci from Caucasian and six loci from South Asian populations) in 1166 T2DM patients and 1235 health...

Objective: Vitamin D deficiency is associated with an increased risk of type two diabetes mellitus (T2DM) and cardiovascular disease reduced through Vitamin D3 supplementation. However to the best of our knowledge, no research has determined the effect of vitamin D3 supplementation in conjunction with existing pharmacological and non-pharmacological approaches to the DMT2 population. Hence, the aim of this study was to determine the effect of vitamin D3 supplementation in a co...

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a member of the phospholipase A2 super family of enzymes that hydrolyse phospholipids, and is upregulated in arterial inflammation, obesity and cardiovascular disease. Secreted soluble Lp-PLA2 (sPLA2) increases arterial inflammation in addition to cytosolic calcium dependent PLA2 (cPLA2) and calcium independent PLA2 (iPLA2). These studies examined the influence of adipose tissue (AT) depots (abdominal subcutaneous (Abd Sc), ...

Introduction: Thyroid cancer (TC) in adolescents and adults (AYA) is defined as thyroid cancer diagnosed among those aged between 15-39 years. It is the fifth most common cancer in AYAs, and its incidence is increasing. Compared with older adult patients, the AYA with TC has a higher prevalence of node metastasis which represents a risk factor for recurrence.Aim: To describe the characteristics of thyroid carcinoma with confirmed nodal metastases at the ...

Introduction: The COVID-19 pandemic has presented many challenges in the management of diabetics around the world. While many people can be managed using new methods such as tele-consulting, the diabetic foot presents unique challenges due to the frequent need for “face-to-face” consultation and treatment. The pandemic has thus made the management of diabetic feet, already complex, even more difficult. This study aims to assess the impact of the COVID-19 pandemic on ...

Introduction: Diabetic foot ulcer (DFU) is one of the leading causes of non-traumatic lower extremity amputations worldwide. Conventional treatment is expensive and often requires a long hospital stay, placing a heavy burden on any healthcare system. Using autologous platelet-rich plasma (PRP), which is rich in various growth factors, can approximate the natural healing process.Objective: Evaluate the place of PRP injections and its interest in the manag...

Introduction: Diabetic foot ulcer (DFU) is one of the major complications of diabetes mellitus. It can be a cause of amputation. A multidisciplinary approach is essential to promote wound healing and decrease amputation rates. Epidermal growth factor (EGF) is used as an adjuvant to close the wound in addition to standard care in diabetic foot ulcers.Methods: This is a prospective study carried out between February 2019 and April 2021 in the department of...

Introduction: The COVID 19 pandemic is causing a considerable degree of fear and concern among the general population. In diabetic pregnant women, this risk is even higher given the physiological and psychological changes that occur during pregnancy.Goal of the study: To evaluate the prevalence and risk factors for the onset of anxiety-depressive disorders in pregnant women with diabetes during the COVID 19 pandemic in comparison with those followed outs...

Introduction: Fasting in the month of Ramadan is one of the pillars of Islam. The diabetic subject, whether he practices it or not, if not prepared expose him to acute complications. The objective of our study was to determine the frequency of occurrence of acute complications during the month of Ramadan.Objectives: To establish the epidemiological profile of diabetics seen in the emergency room during the month of Ramadan. Determine the frequency of occ...