Endocrine Abstracts

IntroductionAcromegalo-gigantism is a rare disease, occurring before the epiphyses weld, it causes a linear acceleration of growth in children and adolescents. Medical treatment with analogues of somatostatin (AS) well established can be used in cases where surgery is impossible or inadequate or in cases of surgical failureObservationThis is a 14-year-old patient, followed for acromegalo-gigantism discovered ...

IntroductionApoplexy is a rare, serious and acute complication of pituitary adenomas, revealed by tumor syndrome, visual disturbances and hormonal deficits in 60% of cases. We report a case in which the diagnosis of acromegaly was revealed by pituitary apoplexy.Observation45-year-old patient. The examination found a tumor syndrome made up of headaches, reduced visual acuity and vomiting which had evolved for ...

IntroductionPrimary thyroid lymphomas (LTP) are a rare entity, characterized by their histological and clinical heterogeneity. They represent 5% of thyroid tumors and 2% of extra-ganglionic lymphomas. We report two observations of LTP by specifying the epidemiological, diagnostic and therapeutic features.ObservationsObservation 170-year-old patient, followed in internal medicine for Sd ...

IntroductionBasedow disease is the most common etiology of hyperthyroidism; the cardiac manifestations seen in hyperthyroidism often affect people over 60 years of age, manifested mainly by sinus tachycardia, atrial rhythm disturbances or increased cardiac output. Pulmonary arterial hypertension and pulmonary embolism are atypical manifestations.Observation39-year-old patient, followed for basedow disease for...

IntroductionDifferentiated thyroid cancers DTC are metastatic in 10% of cases. The most frequent sites are the lungs, the bones, the brain and the liver. The presence of a metastasis reduces the life expectancy of patients by 60%. The objective of this work is to describe the characteristics of metastatic DTC in our service.MethodologyDescriptive retrospective study of 740 patient files monitored at the endoc...

IntroductionPapillary carcinoma is the most frequent histological form of malignant thyroid tumors, increasingly diagnosed at the microcarcinoma stage. Papillary microcarcinomas, often localized, are classified as very low risk.Objective of the studyTo describe the epidemiological and clinical characteristics, the evolutionary profile as well as to determine the predictive factors of recurrence of papillary m...

IntroductionAcromegaly is an acquired endocrine pathology associated with the overproduction secondary to hypersecretion of growth hormone, by a somatotropic pituitary adenoma in more than 90% of cases, the symptoms of which may concern various organs (eye, heart, colon, etc.). skin….). Occasionally, it can present itself in association with skin changes which in some cases are very rare. We report the observation of a patient followed for acromega...

Background: Our previous study revealed a high prevalence of abnormal mineralization markers namely low 25 hydroxyvitamin D (47.9%); high serum alkaline phosphatase (3.7%) and low calcium-phosphate product (9.8%) suggestive of biochemical signs of osteomalacia (OM, defined as any two of these risk factors). OM was more prevalent in girls (11.2%) compared to boys (5.0%). In this follow-up study, we aimed to evaluate if biochemical OM was associated with low intakes of calcium a...

Background: The pathogenesis of obesity and T2DM mediates mitochondrial dysfunction which, in part, may arise as a consequence of endoplasmic reticulum (ER) stress. However, the potential impact of ER stress on mitochondria dysfunction is unclear. Therefore, we investigated whether induction of ER stress contributes to mitochondrial dysfunction in human adipocytes using 1) human differentiated adipocyte cell line (Chub-S7, n=12); and 2) primary differentiated lean and...

Background and aims: Current evidence highlights that dietary cholesterol, trans-fatty acids and saturated fatty acids (SFAs) are all known to increase the levels of systemic atherogenic lipoproteins and cardiovascular disease. The aim of this study was to observe the direct effect of dietary change, via a calorie-restricted diet on i) cardio-metabolic profile and ii) a high-fat meal challenge pre- and post-3-month intervention.Methods: T2DM subjects (Sa...