Endocrine Abstracts

The hypoxia, associated to intra-uterine growth restriction, is related to high concentrations of IGFBP1 and unchanged concentrations of IGF1 in animals. Nevertheless, during threatening life events, low IGFI concentrations and high IGFBP1 concentrations was reported. Furthermore, severe hypoxia increased the IGF1R expression of the neuronal growth cones in the ovine fetal brain. No information is available regarding the regulation of the IGF system by the acute hypoxia in hum...

CCK, secreted from duodenal cells in response to nutrients is involved in the satiety mechanisms, via activation of nucleus tractus solitarius (NTS). The arcuate (ARC) and paraventricular nuclei (PVN), which receives projections from NTS, integrate the circuitry that controls food intake. Corticotrophin releasing factor (CRF) participates in the energy homeostasis, decreasing food intake.To evaluate the effect of glucocorticoid on feeding and neuronal ac...

The family of G-protein coupled receptors (GPCRs) are amongst the best-described regulators of cardiovascular pathophysiology. In rodents, intracerebroventricular administration of orexins increases mean arterial pressure and heart rate. However, important peripheral actions of orexins and their cognate receptors is now increasingly of interest.In this study we demonstrated that both receptors are present across the rat heart, at mRNA and protein level. ...

Lipid profile suffers adaptive changes during pregnancy due to estrogen stimulation and insulin resistance. Several relations have been suggested between maternal lipid profile, glucose tolerance, endothelial cell dysfunction and long-term cardiovascular risk; the effects of maternal lipid profile metabolism in fetal growth are also inconclusive. Since a regular evaluation and follow-up of lipid profile during pregnancy has not been stablished yet, we aimed to evaluate the inc...

Hyperthyroidism during pregnancy is determined by decreased thyroid stimulating hormone (TSH), and high levels of thyroid hormones: thyroxine (T4), triiodothyronine (T3), being a complication in 1–2 women per 1,000 pregnancies, and occurs first as Graves’ disease in 0.1–1% of pregnancies. There are specific reference ranges of THS and free T4 for each population and each trimester. For the medical management in the first trimeste...

Uncoupling protein 2 (UCP2) is a mitochondrial protein located in the mitochondrial inner membrane, and it uncouples substrate oxidation from ATP synthesis, thereby dissipating the membrane potential energy and consequently decreasing reactive oxygen species (ROS) formation by mitochondrial respiratory chain. ROS overproduction is related to diabetic retinopathy (DR), a chronic complication of diabetes mellitus (DM). Recently, our group reported that the -866A/55Val/Ins haplot...

Background: The effect of Roux-en-Y gastric bypass (RYGB) on diabetic kidney disease (DKD) is unclear. We used a Zucker diabetic fatty rat (ZDF) model of DKD to determine the effect of RYGB on histopathological markers of DKD, proteinuria, and MCP1 excretion.Methods: ZDF rats underwent RYGB (n=15) or sham surgery (n=14) at 18 weeks of age. Eight sham operated animals were food restricted to match the weight loss of the RYGB group (body-...

Objectives: The aim of this prospective study was to compare the diagnostic performance of 99mTc-sestaMIBI SPECT scintigraphy (sestaMIBI), 18F-fluorocholine PET/CT or PET/MR (FCH) for preoperative localization of hyperfunctioning parathyroid gland.Materials and Methods: 60 patients with biochemical evidence of primary (n=57) or tertiary (n=3 kidney transplanted patients) hyperparathyroidism were imaged prospectivel...

Background: Adrenocortical carcinoma (ACC) is a very rare and aggressive, endocrine malignancy with still limited treatment options. Approximately 60% of patients with ACC show endogenous glucocorticoid excess which could be one potential cause, why first clinical trials with immunotherapies, like immune checkpoint inhibitors, showed only modest results. Due to the lack of an ACC-specific antigen structure, other immunotherapeutic approaches, like specialized cancer treatments...

Introduction: Due to the widespread use of imaging studies performed in hospitalised patients for other indications, adrenal incidentalomas (AI) are frequent findings in the everyday clinical practice. The objective of this research is to describe the prevalence of hormonally active and malignant AI.Patients and methods: Observational retrospective study of a cohort of patients who consulted in the Endocrinology service between 2005 and 2015 because of a...