Endocrine Abstracts

Acromegaly is a rare disease associated with hypersecretion of growth hormone due to adenoma of somatotroph cells in the pituitary gland, with elevated morbidity and mortality. Acromegaly and thyroid diseases show high co-occurrence. In our study; we aimed to determine the relationship between disease activity at the time of admission and after treatment with the presence of goiter, presence of nodules, and possible accompanying thyroid malignancy in 119 patients with acromega...

Objective: It has been argued that salivary alpha-amylase (sAA) is a potential indirect sympathoadrenal medullary (SAM) system activity marker. This study aimed to look at sAA to assess the sympathetic nervous system in acromegaly patients.Subjects and Methods: A total of 31 individuals with acromegaly and 30 controls were enrolled in this prospective, single-center investigation. Saliva samples were taken from individuals with acromegaly and controls in...

Aim: Serum sclerostin levels as an indicator of bone resorption in children with congenital adrenal hyperplasia (CAH) have not been evaluated to date. The aim of this study was to determine the role of osteoprotegerin (OPG) and sclerostin in bone metabolism in children with CAH.Methods: Thirty-one patients (19 girls, 12 boys) with CAH (aged 11.6±3.7 years) and 31 healthy children (age- and sex-matched) as controls were included in the study. The patie...

Objective: It is not currently well known whether pheochromocytomas can be ruled out based on low intensity on T2-weighted sequences and signal loss on out-off phase magnetic resonance imaging (MRI) sequences. Hence, in this study we aimed to investigate whether biochemical screening for pheochromocytoma in patients with adrenal incidentalomas (AI) showing MRI features not suggesting pheochromocytoma would prove beneficial.Methods: We performed MRI for 3...

Aims: We aimed to determine the irisin level in patients with type 1 diabetes mellitus (T1DM) and to examine the relation of irisin level with inflammation and autoimmunity.Methods: This study included 35 cases diagnosed with T1DM and 36 healthy volunteers. Anti-glutamic acid decarboxylase (Anti-GAD), islet cell antibody (ICA), insulin autoantibody levels of the patients have been measured at the time they were included in the study and were recorded fro...

Introduction: Metformin treatment was associated with decreased risk of various cancers including breast cancer. Exposure to sex steroid is related with increased risk of breast cancer. In this study, we aimed to evaluate the effect of metformin treatment on serum levels of sex steroids and sex hormone binding globulin (SHBG) in postmenopausal women with type 2 diabetes mellitus.Methods: Postmenopausal patients with newly diagnosed type 2 diabetes were r...

Introduction and aim: Osteopetrosis is a rare genetic disorder of reduced osteoclastic bone resorption. Defective bone remodelling induces skeletal sclerosis and abnormally dense but brittle bones. We present here a case of autosomal dominant osteopetrosis type II as a cause of high bone mineral density (BMD).Case report: A 52-years-old woman with a complaint of bone pain and headache referred to our clinic for evaluation of high BMD. Her medical history...

Objective: Elevated levels of the soluble adhesion molecules, sICAM-1 and sVCAM-1 reflect chronic inflammatory state. Increased levels of sICAM-1 and sVCAM-1 were demonstrated in various autoimmune thyroid diseases with abnormal thyroid function, but their clinical significance is undefined, especially in the euthyroid patients with Hashimoto’s thyroiditis (HT). Increased levels of soluble adhesion molecules are also associated with components of the metabolic syndrome li...

Introduction: We report the first case of metastatic adrenocortical carcinoma (ACC) concomitantly secreting cortisol, aldosterone, catecholamines and androgens with the extensive distant metastasis at the time of diagnosis.Case report: A 57-year-old woman referred for left adrenal mass (5.5×4.0 cm) two years after the diagnosis of breast cancer. The patient’s medical history revealed hypertension and diabetes mellitus. She has cushingoid and hy...

Introduction: Primary hyperparathyroidism (PHPT) occurs a peak incidence between ages 50 and 60 and the classical bone disease of PHPT or pathological fractures due to PHPT is rarely seen today. Furthermore brown tumor detected with Tc-99m MIBI scintigraphy exists in literature infrequently.Case: A 23 years old woman presented with left arm pain admitted in Department of Orthopaedics for pathological fracture in left humerus. As a result of investigation...