Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting approximately 4–8% of premenopausal women. The main clinical features are clinical and/or biochemical hyperandrogenemia, oligomenorrhea and polycystic ovarian changes. It has gained a great attention during the last two decades with the realization that this syndrome affects more than the reproductive system. Epilepsy is a common neurologic disorder affecting women during the reproductive years. Sei...

Introduction: Although the etiology of osteoporosis is different between men and women, the underlying pathophysiologic mechanism is similar, namely an absolute or relative increase in bone resorption, leading to progressive bone loss. Transforming growth factor (TGF) beta-1 is a growth factor in human bone, which is produced by osteoblasts and inhibits osteoclast proliferation and activity and stimulates proliferation and differentiation of preosteoblasts.<p class="abstex...

Introduction: Papillary thyroid carcinoma(PTC) and medullary thyroid carcinoma(MTC) have always been considered different tumors. Concomitant presence of MTC and PTC in the same patient is a rare clinical event.Case report: A 43 year-old woman admitted with fatigue, a serum thyrotropin of 4.6 uIU/ml and a 15×11 mm thyroid nodule in right lobe detected in another center. Fine needle aspiration(FNA) of the nodule was consistent with MTC. In family his...

Introduction: Recently, Programmed cell death ligand 1 (PD-L1) inhibitors have been frequently used as promising treatment options for some advanced malignancies. Although immune-related side effects secondary to PD-1 inhibitor treatment are well defined in the literature, data on PD-L1 inhibitors are limited. Thyroid dysfunction was reported in 10% of patients in the clinical study of atezolizumab. We aimed to present a case of severe hypothyroidism-related rhabdomyolysis and...

Introduction: Ten per cent of pheochromocytomas are malignant. Malign pheochromocytoma could cause metastasis, relapse and local invasion. The most common sites of metastasis for pheochromocytoma or extra-adrenal paraganglioma are lymph nodes, bones, lungs, and liver. Here, we present a case who had pheochromocytoma relapse and unusual peritoneal metastasis after 12 years of left adrenalectomy.Case presentation: A 38 year-old woman, who had left adrenale...

Aim: Metabolic syndrome rates have been studied especially in adrenal gland secreting cortisol and studies on nonfunctional adenomas are limited. In this study, we investigated metabolic parameters and metabolic syndrome frequency in non-functional adrenal adenomas (NFA).Materials and methods: In our study, 55 patients (15 men (27.3%), 40 women (72.7%) who were diagnosed incidentally, unilateral or bilateral localized, hormone-inactive, and with adenoma-...

Introduction: Hyperkalemia due to zona glomerulosa (ZG) insufficiency is generally transient and mild for patients with aldosterone-producing adenoma (APA) after adrenalectomy. We report here a case with prolonged ZG insuffiency requiring long-term mineralocorticoid replacement (MR) therapy.Case report: A 45-years-old female with hypertension and hypokalemia admitted to outpatient clinic with incidentally detected right adrenal adenoma (3 cm) showing sig...

Introduction: Hypogonadism persisting in man with macroprolactinoma requires exogenous testosterone replacement therapy (TRT). But TRT may cause secondary elevations of prolactin. We report here a case of macroprolactinoma and hypogonadotropic hypogonadism with persistently high prolactin level after initiating TRT.Case report: A 28 year-old male was admitted to outpatient clinic with complaints of headache, low libido and blurred vision on left eye for ...

Purpose: To determine the relationship between grade of diabetic retinopathy and serum vitamin D levels in diabetic patients.Materials and methods: A total of 173 diabetic patients consisting of patients without retinopathy (n=67), patients with non proliferative diabetic retinopathy (NPDRP group n=47), patients with proliferative diabetic retinopathy (PDRP group n=59) was included in the study. Age and sex matched 55 healthy s...

Background: Recombinant human thyroid-stimulating hormone (rhTSH)-stimulated serum thyroglobulin (Tg) (s-Tg) and (131)I whole-body scanning (WBS) are supposed to provide equal diagnostic information with thyroxine withdrawal (THW) at follow-up thyroid cancer patients without the symptoms of hypothyroidism. We aimed to compare the WBS and s-Tg levels after thyrogen injection and thyroid hormone withdrawal for tumor recurrence/persistance according to the risk groups.<p clas...