Endocrine Abstracts

ObjectiveScanty data about glucose metabolism, hypertension and metabolic syndrome (MS) have been reported in Paget’s disease of bone (PDB) to be related with increased cardiovascular mortality. We aimed to determine prevalence of metabolic syndrome in PDB and to determine the relationship between metabolic syndrome and bone-specific alkaline phosphatase levels.Patients and methodsTwenty three patients w...

ABSTRACT WITHDRAWN...

Introduction: Adrenocortical carcinoma (ACC) is a rare tumor with an aggressive prognosis of 1–2 people per million per year. They are functional tumors which mostly occur with virilization and/or Cushing syndrome. Metastatic ACC has a dismal prognosis and the most common sites of metastases are the lung, liver, lymph nodes and bones. Herein, we present metastatic ACC patient without Cushing clinic at the time of diagnosis.Case presentation: A 48-ye...

Aim: Bisphenol A (BPA) is the most common endocrine disruptor among environmental estrogens. BPA is an ingredient that is commonly used in polycarbonate plastics. In this study, our main concern is to measure the levels of BPA in premenopausal obese women and to examine the relationship of BPA with adiponectin and leptin.Materials and methods: 47 obese women and 39 non-obese healthy women were enrolled in this study. All participants were premenopausal. ...

Introduction: APECED syndrome is characterized by the three most common components of the condition, i.e. mucocutaneous candidiasis, autoimmune hypoparathyroidism, and Addison’s disease. Presence of two of these components suffices for diagnosis.The case: A 33-year-old female patient presented to the endocrinology polyclinic for weakness, nausea, vomiting, dizziness, recurring vaginal itch, and discharge for 1 year, intermittent dysphagias and ameno...

Background: Currently, multiple treatment options are available for the treatment of acromegaly. However, cure is obtained only in 50% of patients with macroadenomas after surgery. Persistent tumor enlargement occur in 2.2% of the patients treated with somatostatin analogs and in 1.6–2.9% of the patients treated with pegvisomant. The nuclear antigen Ki-67 is related to growth potential and is also a major prognostic indicator for pituitary adenomas. Studies demonstrated t...

Background: Currently, no effective medical treatment exists for recurrent and aggressive craniopharyngiomas that are resistant to conventional therapies, including repeat surgeries and adjuvant radiotherapy (RT). Temozolomide is an alkylating chemotherapeutic agent and is used routinely in the management of high grade gliomas. The response to temozolomide is suggested to be dependent on the tumoral expression of O-6 methylguanine DNA methyltransferase (MGMT). Evidence ...

Objective: Endogenous hyperthyroidism is associated with altered coagulation. The aim of the present study is to investigate the effect of levothyroxine (LT4) suppression treatment for benign thyroid nodules on coagulation system.Design: Prospective case-control study.Patients: Thirty consecutive euthyroid pre-menopausal women with nodular goitre disease and 28 healthy controls were included in the study.Meas...

Thyroid dysfunction is associated with altered levels of several coagulation factors. The aim of this study is to investigate the effect of levothyroxine suppression therapy for benign thyroid nodules on coagulation system.Thirty-six patients with benign thyroid nodules, who were applicant for levothyroxine suppression therapy, were included in the study. Thirty patients completed 1 year follow-up period. Levothyroxine was given to maintain TSH level bet...

Introduction: Vitamin D (Vit D) receptors have been shown in extra skeletal tissues. Vit D deficiency plays a role in the development of many malignant, chronic inflammatory, autoimmune and metabolic diseases. Our aim was to evaluate the effect of Vit D replacement therapy on insulin sensitivity, endothelial function and oxidative stress in Vit D deficient subjects.Material-method: Serum 25(OH) D levels of 74 volunteer-healthy subjects (22.7±2.7) we...