Endocrine Abstracts

Objective: The aim of this study was to determine the change in serum ischemia-modified albumin (IMA) level and oxidative stress markers (total antioxidant status, TAS, total oxidant status, TOS) in patients with metabolic syndrome (metS).Research design and methods: We studied 52 metS patients (56.74±12.75 mean age), and 36 control subjects (54.47±6.52 mean age). The presence of metS was diagnosed according to National Cholesterol Education Pr...

Background: Acromegaly is a multi-systemic dysfiguring disease caused by pituitary GH secreting tumour. Pituitary surgery, medical treatment with somatostatin analogues and radiotherapy have been cornerstone in the management of acromegaly. However, all these treatment modalities do not provide sufficient disease control especially in patients with macroadenomas.Objective: To evaluate the follow-up outcomes and remission rates of acromegaly patients....

Data regarding cardiovascular risk in subjects with non-functioning adrenal adenoma is limited. The aim of this study is to investigate osteoprotogerin (OPG) and Interleukin-6 (IL-6) levels in subjects with non functioning adrenal incidentalomas.Of 51 subjects without findings of hypercortisolism or other adrenal gland disorders (AI), 32 BMI-unmatched controls (C) and 20 BMI-matched controls (BC) were enrolled. Participants underwent hormonal evaluation ...

ApoB plays a central role in lipoprotein metabolism through regulation of total cholesterol and LDL-cholesterol (LDL-C) concentrations in plasma. Two restriction fragment length polymorphisms (ECoRI and XbaI) represent single base alterations in the coding region of ApoB gene. ECoRI polymorphic region of ApoB gene is due to on an amino acid change (Glu→Lys). The XbaI polymorphic region of ApoB gene results from a substitution of (A→T) in the threonine codon and doe...

Objective: Acromegaly is associated with an increased prevalence of colonic polyps. The aim of this study was to evaluate the prevalence of colonic polyps in acromegalic subjects, and also whether there is a relationship between insulin-like growth factor 1 (IGF-1), growth hormon (GH), fasting insulin plasma levels and the presence of polyps.Material and methods: Fifty-four consecutive acromegalic patients and 45 IBS patients were enrolled to study betwe...

Acromegaly is known to be associated with insulin resistance. Visceral adipose tissue is increased in patients with insulin resistance and we aimed to investigate a visceral adipose tissue content as a possible marker of insulin resistance in diabetic and nondiabetic acromegalic patients. We compared 16 diabetic and 16 nondiabetic acromegalic patients for fasting blood glucose (FBG), insulin and visceral adipose tissue content calculated from abdominal computer tomography. All...

Acromegaly is known to be associated with both increased cardiovascular mortality and carbohydrate intolerance. The aim of our study is to compare intima-media thickness, a marker of atherosclerosis in active acromegalic patients with and without diabetes. 32 active acromegalic patients (M/ F: 15/17, 16 diabetic and 16 nondiabetic) were assessed for fasting blood glucose (FBG), insulin, growth hormone, insulin-like growth factor 1 and carotid intima-media thickness (IMT). Diab...

Increased heel pad thickness can be used as a marker of soft tissue enlargement in acromegalic patients. We aimed to investigate if concomittant hyperinsulinemia/and or diabetes secondary to insulin resistance in acromegaly contribute to the enlargement of heel pad. We compared heel pad thickness in 16 diabetic and 16 nondiabetic active acromegalic patients using X-ray images. All of the diabetics were well controlled with diet and/ or oral antidiabetic drugs. GH and IGF-1 wer...

Hungry bone syndrome (HBS) is associated with recent parathyroid surgery. The Wolfram syndrome is characterised by diabetes insipidus, diabetes mellitus, optic atrophy and deafness. Other anomalies, such as renal outflow tracts and multiple neurological disorders may develop later. We present a Wolfram patient with tertiary hyperparathyroidism due to chronic renal failure associated with bilateral reterohidronephrosis who developed prolonged HBS after parathyroid adenomectomy....

Objective: Polycystic ovary syndrome (PCOS) is closely associated with insulin resistance (IR) and about 50–70% of women with PCOS have significantly increased IR. Our study was performed to determine the effects of metformin on IR indices with lean PCOS patients.Methods: Our study was a single center, randomized prospective study, approved by the local ethical committee. 53 patients with BMI <25 kg/m2 who had chronic anovulation and ...