Endocrine Abstracts

Introduction: Glucocorticoids (GC) are the first line treatment for moderate-to-severe and active Graves’ orbitopathy (GO), but optimal treatment is still undefined. The aim of the present study was to analyze the efficacy and tolerability of combined parenteral GC pulse therapy followed by oral GC in the interpulse period.Methods: The study includes 50 patients (48±10 years; 37 females) with untreated, active and moderate-to-severe GO. Patient...

Introduction: Changes in thyroid function have significant impact on the cardiovascular system.Methods: In a group of 37 subjects the level of thyroid hormones FT4, FT3, and TSH were measured. Then carried out short-term analysis for 30 min measureing variability of blood pressure with non-invasive TASK FORCE monitor. Registered data were analyzed by spectral analysis of variability. Statistical analysis were done by Pearson correla...

Introduction: Isolated IgA deficiency (SIgAD) is the most common form of primary immunodeficiency. Patients with SIgAD have an increased risk of both systemic and organ-specific autoimmune diseases. Autoimmune thyroid diseases (AITD) and type 1 diabetes mellitus (T1DM) are the most common autoimmune endocrine disorders. They occur frequently together, and this combination is nominated as autoimmune polyglandular syndrome type 3 (APS 3). Primary hyperparathyroidism (PHPT) is th...

Background: Ketoconazole is a synthetic antifungal drug, and powerful inhibitor of steroidogenesis. Oral ketoconazole blocks both ovarian and adrenal androgen biosynthesis, and glucocorticoid synthesis, leading to a reduction in circulating testosterone and cortisol levels. In subjects with an intact HPA axis, ketoconazole by decreasing cortisol levels leads to compensatory rise an ACTH level.Objectives: To assess influence ketoconasole induced changes i...

Aim: The aim of this study was to compare clinical symptoms and TSH receptor antibodies (TRAb) in Graves orbitopathy (GO) in hyperthyroid patients to those patients with primarily hypothyroid and euthyroid status.Methods: Study group consisted of 54 primarily hyperthyroid (39 female, 14 male, 47±9 years) and 8 primarily hypothyroid and euthyroid patients (5 female, 3 male, 46±14 years). Clinical symptoms and TRAb were assessed. Assessment of th...

Background/objectives: The aim of the study was to assess hypothalamic–pituitary–adrenal (HPA) axis in patients with chronic fatigue syndrome (CFS).Design and methods: Twenty-three consecutive patients who fulfilled centers for disease control (CDC) criteria for CFS and twenty healthy controls were included in the study. Low dose ACTH test (1mcg of synthetic adrenocorticotropic hormone Synacthen) and insulin tolerance test (ITT) were done and b...

Background/objectives: The aim of the study was to assess association between diabetes mellitus (DM) and arterial hypertension (AH) in patients with adrenal incidentaloma.Design and methods: One hundred and eleven consecutive patients with incidentally discovered adrenal tumours were included in the study. OGTT was done and 24 h urinary catecholamines were measured. Aldosterone and plasma renine activity (PRA) were determined, and 1 mg dexametasone test ...

Background: Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disease that occurs in about 10% of women in reproductive age. Today, PCOS is considered not only reproductive edocrinopathy but also a metabolic disorder associated with long-term health risks, including diabetes mellitus and cardiovascular disease.Objectives: The aim of this study was to evaluate the presense of early vascular demage in normal-weight women with polycystic ovar...

The aim of the study was to assess the influence of thyroid hormones on lipid profiles in primary hypothyroidism, in order to determine the most influential one for the clinical follow-up. Study group included 15 subjects (3 male, 12 female, age 46±13 years/mean±S.D.), and total and free T4, total and free T3 and TSH, total, HDL and LDL cholesterol, triglycerides, ApoA, ApoB and Lp(a) were determined. The diagnosis of primary hypothyroidism was based o...

Background: Hypothyroid Graves’ ophthalmopathy is a rare condition, present in about 3% of all cases. Since thyroid-stimulating antibodies could be detected in a majority of euthyroid and hypothyroid Graves’ patients, the most probable explanation for unincreased thyroid function is a reduction of tissue capability to response to stimulation.Case report: A 57-yr-old man visited the hospital with signs and symptoms typical of hypothyroidism. Sin...