Searchable abstracts of presentations at key conferences in endocrinology

ea0081p573 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Total daily dose of insulin at the beginning of treatment with Continuous Subcutaneous Insulin Infusion system: which is the best formula?

Benido Silva Vania , Garrido Susana , Vilaverde Joana , Teixeira Sofia , Cardoso Maria Helena

Introduction: Several formulas are described to calculate the Insulin Dose to start insulin pump therapy. However, there are no data demonstrating their effectiveness in achieving good glycemic control.Aim: To assess the Total Daily Dose of Insulin (TDDI) at 3 months after beginning an insulin pump, and determine which formula most closely matches the TDDI required in cases where good glycemic control is achieved after that period....

ea0049ep921 | Neuroendocrinology | ECE2017

Kallmann syndrome: about eleven clinical cases

Fonseca Liliana , Amaral Claudia , Dores Jorge , Palma Isabel , Carvalho Rui , Cardoso Helena , Vilaverde Joana , Borges Fatima

Idiopathic congenital hypogonadotropic hypogonadism (CHH) is a rare reproductive disorder that is primarily caused by a gonadotrophin-realising hormone (GnRH) deficiency. When CHH is associated with hyposmia or anosmia is designated by Kallmann Syndrome (KS). This syndrome is a genetic disorder with significant genetic heterogeneity that may present as a sporadic or familial case, following autosomal dominant, autosomal recessive, or X – linked recessive modes of inherita...

ea0041ep554 | Diabetes therapy | ECE2016

Economic impact on the use of insulin pumps in diabetes type I – analysis on Portuguese real life results

Joaquim Ines , Vilaverde Joana , Barros Luisa , Diniz Isabel , Sabino Filipa , Boavida Jose Manuel , Cardoso Helena

Although, diabetes type I patients in Portugal have complete and free access to HbA1c management (via multiple daily injections) only a few percentage has been provided an insulin pump – priority is given to children and women in fertile age trying to get pregnant. By the end of 2014, 1.150 insulin pumps had already been provided by the National Program of Insulin Pumps, but at least 3.000 patients with indication for insulin pump use were in waiting list. HbA1c pre-pump ...

ea0035p329 | Clinical case reports Thyroid/Others | ECE2014

Two serious complications of propylthiouracil treatment in the same patient: case report

Garrido Susana , Pereira Teresa , Marinho Antonio , Freitas Claudia , Vilaverde Joana , Amaral Claudia , Carvalho Andre , Borges Fatima

Introduction: Thionamides are important drugs in the treatment of hyperthyroidism. Despite that, they can be associated with rare but serious complications, which require drug discontinuation.Case report: Sixty-five-year-old woman with Graves’ disease, treated in 2002 with methimazole and in remission until 2012. Recurrence of Graves’ disease was diagnosed in March 2012 and she was started on propylthiouracil (PTU) 150 mg per day. She presented...

ea0035p457 | Diabetes complications | ECE2014

Diabetic ketoacidosis and olanzapine: case report

Garrido Susana , Pereira Teresa , Freitas Claudia , Vilaverde Joana , Amaral Claudia , Carvalho Andre , Borges Fatima

Introduction: Patients with psychotic or depressive disorders have an increased risk of developing metabolic syndrome, not only because of their unhealthy lifestyle (sedentary habits, inadequate diet and smoking) but also because of the negative impact of antipsychotic agents (specially clozapine and olanzapine) on several metabolic features. These include overweight/obesity, dyslipidemia, development of new-onset type 2 diabetes, worsening of pre-existing diabetes and diabeti...

ea0070aep486 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Glycemic variability in type 1 diabetes

Santos Tiago , Inácio Isabel , Soares Bruno , Vilaverde Joana , Teixeira Sofia , Cardoso Helena

Introduction: Glycemic variability (GV) is emerging as a measure of glycemic control in type 1 diabetic patients (T1DM) given that it provides an integrated picture of postprandial hyperglycemia and hypoglycemic episodes and is associated with diabetic complications and mortality. However, little is known about the best way to address this problem in clinical practice.Aim: To characterize GV in T1DM patients followed in our center and to identify clinica...

ea0070ep235 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Flash glucose monitoring in type 1 diabetes: Real world data

Borges Duarte Diana , Santos Tiago , Fonseca Liliana , Teixeira Sofia , Vilaverde Joana , Cardoso Maria Helena

Introduction: Clinical trial data demonstrate improved glycemic control in individuals with type 1 diabetes (T1D),especially, reduction of time in hypoglycaemia with flash glucose monitoring (FGM);however real-life conditions can modify this scenario.Aim: To examine real world use and glycemic control following a standardized initiation process of FGM.Methods: Individuals aged 18 years or older with T1D were prospectively recruited...

ea0037ep460 | Diabetes (complications & therapy) | ECE2015

Establishing the relationship between third-trimester foetal abdominal circumference, birthweight, and neonatal morbidity in gestational diabetes

Pereira Maria Teresa , Garrido Susana , Almeida Raquel , Vilaverde Joana , Pichel Fernando , Pinto Clara , Goncalves Joaquim , Dores Jorge

Introduction: Gestational diabetes (GD) is associated with a significantly higher risk of perinatal complications. It has been suggested that third-trimester (3thT) foetal abdominal circumference (fAC) determination is an important predictor of macrossomia and large for gestational age (LGA).Aims: The purpose of this study was to evaluate the association between the 3thT fAC percentile with birthweight (BW) and adverse neonatal outc...

ea0037ep552 | Obesity and cardiovascular endocrinology | ECE2015

Influence of normal food intake on the lipid profile of diabetic patients

Garrido Susana , Almeida Raquel , Pereira Teresa , Ferreira Lia , Neto Helena , Vilaverde Joana , Pichel Fernando , Oliveira Jose Carlos , Palma Isabel

Introduction: The need to fast for the determination of lipid profile has been discussed in the past years, for several reasons – i) most of the day time is spent in a postprandial state; ii) the lipid concentrations seem to be only slightly affected by a normal meal; both fasting and postprandial can predict cardiovascular risk.Aim: Determine the influence of normal food intake on the lipid profile of diabetic patients.Method...

ea0056ep15 | Adrenal and Neuroendocrine Tumours | ECE2018

IGF-2-oma: a diagnosis to be considered in a patient with a leiomyosarcoma and recurrent hypoglycemia

Fonseca Liliana , Ferreira Lia , Pereira Teresa Alves , Lopes Ana , Almeida Raquel , Vilaverde Joana , Pereira Maria Teresa , Cardoso Helena

Introduction: Non-islet cell tumor induced hypoglycemia (NICTH) is a paraneoplastic phenomenon involving many types of tumors. It is associated with the secretion of incompletely processed precursors of IGF-2 resulting in a persistent insulin-like activity and hypoglycemia. Most commonly, IGF-2–linked hypoglycemia has been observed in patients with solid mesenchymal or epithelial tumors. Typically, elevated IGF-2 levels are associated with suppressed plasma levels of insu...