Endocrine Abstracts

Introduction: Obese patients are at an increased risk of develop nonalcoholic fatty liver disease. Evidence supports that bariatric surgery might have an important impact on hepatic profile in obese adults. Literature suggests that bariatric surgery in adolescents might decrease the prevalence of some comorbidities, but information about its impact on liver profile and steatosis and fibrosis risk remains scarce.Aim: To evaluate the impact of bariatric su...

Introduction: Obesity is a complex multifactorial disease and its prevalence in pediatric age has increased. Obesity prejudices the individual metabolic profile due to the adipotoxicity involved in this condition. Bariatric surgery improves the weight of obese patients along with metabolic comorbidities, being today one of the most effective treatments for obesity. Time of exposure to adipotoxicity appears to be an important risk factor for the development of metabolic complic...

Introduction: Clomiphene citrate (CC), a selective estrogen receptor modulator that increases LH and FSH secretion, improves hypogonadism and fertility outcomes. Moreover, there is limited evidence that it may also be helpful as add-on therapy to normalize IGF-1 levels in male acromegalic patients.Objective: To assess the effect impact of CC on serum IGF-1 and testosterone levels in male acromegalic patients not controlled by the combination of lanreotid...

Evaluation of bone quality represents a challenge since the analysis by bone mineral density (BMD), provides useful but incomplete information. New tools are arising, and amog them, TBS is emerging as a new surrogate marker of bone texture and microarchitecture which may be useful to potentially evaluate the risk of bone fracture and can be obtained from already existing BMD scans. Retrospective study of 23 patients with PHH. Clinical, analytical and BMD data were collected fo...

Introduction: Recent studies suggest that some patients initially diagnosed with congenital hypogonadotropic hypogonadism (CHH), may evolve towards a combined pituitary hormonal deficiency (CPHD). Heterozygous pathogenic CHD7 variants impair neural cell crest guidance causing CHARGE syndrome and have been associated with abnormal pituitary development/function/structure and isolated CHARGE features, including HH. We aimed to genotype CHD7 and phenotype thoroughly those adult p...

In liver, melatonin (Mel) and glucocorticoids (GC) influence the systemic energy homeostasis. Animals without pineal gland present impairment in glycemic control, as in type-2 diabetes. In turn, Mel reduces the GC levels, particularly in nocturnal animals. We aimed to evaluate the influence of Mel, as well as GC receptor blockade by RU486 treatment on hepatic and pancreatic energy metabolism. Male Wistar rats were subjected to surgical removal of pineal and, 25 days after the ...

Background: Pregnancy alters the natural history of autoimmune thyroid disorders. The incidence rate of positive thyroid antibodies (T-abs +) in asymptomatic women during pregnancy has been reported to be between 6 and 19.6%.Aim: To determine the prevalence of thyroid antibodies (T-abs) in Gestational Diabetes Mellitus (GDM).Subjects & Method: In 408 women, at the time of diagnose of GDM, TSH, free thyroxine, free tri-iodothyro...

Introduction and objective: Prevalence of obesity is increasing in fertile women. We aimed to investigate its relation with pregnancy outcome.Methods: A retrospective analysis of 37 obese pregnant women (O group) was undertaken in the Endocrinology/Obstetric Unit, from 1998 to 2004. Control group included 33 pregnant women (C group) with normal body mass index (BMI).Results: Our O and C groups were age matched (O: 27.9±4.35; C...

Introduction, material and methods: The BRAF isoform of RAF has been implicated in the pathogenesis of papillary thyroid cancer, but not of benign or follicular neoplasms. Also, BRAF mutations may confer a worse clinical prognosis than for papillary thyroid cancer without the BRAF mutation. Recurrence occurs more frequently when BRAF mutations are present. In addition, BRAF mutations are associated with extrathyroidal invasion, lymph node me...

*These authors contributed equally to this workIntroductionThe prevalence of obesity has risen dramatically worldwide in the last three decades. Due to this obesity pandemic, a growing demand for weight-loss drugs has emerged. The increased use of these drugs has consequently lead to an increase in the report of adverse reactions.Case reportA 45-year-old woman with past medical history ...