Endocrine Abstracts

Ceramides (Cer), which are known to be altered in plasma before the onset of coronary artery disease (CAD), have been proposed as new markers for cardiovascular disease (CVD) risk. Serum Cer18:1/C16:0, Cer18:1/C18:0 and Cer18:1/C24:1 to Cer18:1/24:0 indexes are proposed to be indicative of CAD. Epicardial adipose tissue (EAT) is a visceral adipose tissue, surrounding and in direct contact with the myocardium and coronary arteries, which volume is considered a risk factor for C...

Introduction: Hypogonadotropic hypogonadism is the cause of sexual deficiency, sometimes difficult to differentiate from constitutional growth delay (CGD).Clinical case: A 19-year-old male consulting endocrinology for delayed puberty. Pointed to, at 13 years of age, as having had CGD. His medical report include a viral meningitis at 8 years of age and anosmia since 3 years of age. He expressed lack of sexual desire and concern about the size of his genit...

Introduction: One of the main difficulties in the study of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is their wide heterogeneity and variable outcome. Several potential influencing factors on patient survival have been recently identified. These factors could help predict patients’ prognosis.Objectives: Analysis of long-term survival of our GEP-NETs cohort according to the presence of metastatic disease, tumor grade, age, sex, tumor fu...

Gestational diabetes mellitus (GDM) is associated with an increased risk of pregnancy-induced hypertension (PIH). Ambulatory blood pressure monitoring (ABPM) has been used to screen for PIH and preeclampsia. To date, there are no data regarding ABPM in women with GDM. Currently, little is known in GDM about the role of inflammatory biomarkers in PIH development and their impact on perinatal morbility and the risk of future complications. With this study we aim to identify, in ...

Introduction: New techniques such as etapification ecotomography (EE) have led to less invasive surgeries in Differentiated Thyroid Cancer (DTC). The trend in recent years has been to a reduction in the doses of radioiodine administered. Our hospital in 2013 incorporated these features to protocolize the administration of radioiodine depending on the characteristics of the tumour and the initial thyroglobulin levels, which may have had an impact in the response to treatment (R...

Introduction: The prediction of the risk of recurrence in differentiated thyroid cancer (dtc) in chile is different from ata. The use of the stimulated thyroglobulin (tg) post-surgery in the prediction of the risk is controversial. We present a cohort applying a new local protocol that includes the tg for supporting the discrimination of the patients for offer low doses or radio iodine.Objective: Asses if the local risk classification (lc) allow us to di...

Introduction: Angiopoietins (ANG) -1 and 2, their receptor TIE2, and the vascular endothelial growth factor (VEGF) are involved in the process of angiogenesis. However, their role in the pathogenesis and development of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) is not completely understood. In a previous study of 42 patients with GEP-NET, we observed an elevation of these serum markers, especially in those with metastatic disease. The objective of this study was ...

Recent evidence shows that are modifiable risk factors and preventable, the most responsible for the high morbidity and mortality secondary to multiple chronic conditions (MCC), and smoking is one of the most important representatives. However, we still lack studies of populations with MCC and its association with smoking status.Objectives: To identify clinical and psychosocial characteristics according to the status of smoking among users with MCC, at h...

Introduction: Cushing’s disease (CD) is responsible for 80% of endogenous Cushing’s syndrome (CS). However, distinguishing the cause of ACTH-dependent CS – CD vs ectopic CS – can be extremely difficult. Bilateral inferior petrosal sinus sampling (IPSS) has the highest diagnostic accuracy in this evaluation.Objectives: The aims of this study were to determine the accuracy of bilateral IPSS in the differential diagnosis of ACTH-dependen...

Aims: To study if BRAF V600E mutation in thyroid fine needle aspiration (FNA) is associated with specific ultrasound (US) characteristics.Patients and methods: From 2010 to 2014 we reviewed patients with thyroid nodules with the following inclusion criteria: US guided FNA of the nodule and molecular testing for BRAF V600E on the FNA. BRAF mutation was detected using fluorescence melting curve. An expert on US, blinded to the BRAF status reviewed US exami...