Endocrine Abstracts

Introduction: Multiple primary cancers are a rare entity; however their incidence is increasing due to advances in diagnostic methods and surveillance strategies. The coexistence in the same patient of several primary malignant tumors has been described in the literature with a frequency varying from 5.5% to 8.5%.The aim of this observation is to report a case associating 3 neoplasias:medullary thyroid carcinoma (MTC), papillary thyroid carcinoma (PTC) a...

Introduction: Anaplastic thyroid carcinoma are highly aggressive solid tumors, with a median survival of less than 6 months after diagnosis. They typically occur in patients who are 65 years of age or older. On the other hand, papillary thyroid carcinoma and follicular thyroid carcinoma are generally indolent, with very few progressive cases.Case report: A 64-year-old patient with no significant pathological history, known with goiter for about 40 years ...

Background: Fibroblast growth factor 21 (FGF21) is a key metabolic regulator in the adaptation to fasting. In food-restricted mice, inhibition of skeletal growth appears to be mediated by the antagonistic effect of FGF21 on GH action in the liver and in the growth plate (Kubicky et al. 2012, Yu et al. 2012). The role of FGF21 in growth regulation in humans is currently unknown.Objective and hypothesis: To provide mechanistic insights in...

Ganglioneuromas are benign sympathetic tissue tumors originating from neural crest cells. A 40-year-old female patient, was admitted to our department for endocrinological evaluation of incidentally discovered tumor of right adrenal gland. For about a year before admission she had a pain under the right costal arch. An ultrasound and computed tomography (CT) showed 2 ovoid cystical tumors of right adrenal (34 and 32 mm, respectively). Three months prior admission she had sever...

Introduction and aimsMacroscopic angioinvasion associated to lymph node metastasis from follicular thyroid carcinoma (FTC) is scarce and leads usually to a poor outcome.Subjects and methodsWe report a case of FTC with extensive vascular invasion into the right jugular vein and numerous lymph nodes. We reviewed clinical records of our patient and analysed clinical outcomes and thyroglobulin rate as well as ima...

Introduction: Glycogenic hepatopathy(GH) refers to excessive intrahepatic glycogen accumulation in patients with poorly controlled diabetes mellitus especially type 1 diabetes mellitus. It is a rare and frequently misdiagnosed complication of diabetes mellitus. The patients present with non-specific pain abdomen may be incidentally detected during evaluation of deranged liver function tests(LFT).Case report: A 15 years old female presented with pain abdo...

Introduction: Medullary thyroid cancer is a rare neoplasm, accounting for approximately 4% of all cases of thyroid cancer. Exceptionally, it can be associated with the hormonal production of ACTH or CRH, causing ectopic Cushing’s syndrome.Clinical Case: We present the case of a 43-year-old man who, as a history of interest, presented a T6-T8 vertebral body fracture 2 years ago and a right hip fracture 1 year ago. Bone densitometry is compatible with...

Introduction: Resistant thyrotoxicosis is condition in which patients fail to respond to maximal doses of antithyroid drugs. Definitive treatment is radioactive ablation and operative treatment. However, achievement of euthyroid status before definitive treatment is important in patients with underlying cardiovascular disorder in whom thyroid crises can be detrimental.Case report: We describe a case of resistant thyrotoxicosis and right heart failure. A ...

Pheochromocytoma (PCC) is a rare neuroendocrine tumor, mainly sporadic, many cases are discovered incidentally by computed tomography or magnetic resonance imaging of the abdomen. Malignancy in pheochromocytoma is difficult to diagnose microscopically. Therefore, only the presence of distant metastases, derived from pleomorphic chromaffin cells, is widely accepted as a criterion of malignancy (1)Case presentation: In March 2016, a 43 year old women prese...

BackgroundCurrently, serious complications of secondary hyperparathyroidism (sHPT) are rare due to early diagnosis and more effective treatments. These complications include osteitis fibrosa cystica, which is characterized by bone resorption and brown tumors. Depending on the location, they can cause pain or compressive symptoms.Case reportWe report a case of a 41-year-old black woman with a past medical hist...