Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is associated with adiposity and metabolic changes predisposing to insulin resistance. Because the recently discovered GH secretagogue, ghrelin is intimately involved in the control of appetite and weight regulation, we investigate ghrelin levels in non-obese and obese PCOS patients. Ten obese (BMI=32.50±1.57 kg/m2) and ten non-obese (BMI=20.45±0.51 kg/m2) patients with PCOS and their respective controls were eva...

It was previously shown that patients with primary hyperparathyroidism (PHPT) are insulin resistant. The aim of our study was to evaluate the effect of surgical treatment on insulin sensitivity and lipid levels in patients with PHPT. In 21 patients with PHPT (age: 56.24±8.69 years, BMI 25.2±3.81 kg/m2) lipid levels (TC, HDL, LDL, TG, Lp(a)) and insulin sensitivity were determinated before and 4 months after surgical treatment. Insulin sensitivity was evalu...

Patients with primary hyperparathyroidism (PHPT) are insulin resistant. The effect of PHPT on lipid levels and low-grade inflammation leves is unknown. The aim of our study was to estimate the cardiovascular risk profile in patients with PHPT. Methods: In patients with PHPT (N=19; age: 58.15±8.38 years; PTH 180.83±104.15 ng/l, calcium 2.97±0.19 mmol/l) insulin sensitivity (measured using euglycemic hyperinsulinemic clamp - M value), lipids (total choleste...

It was reported that patients with primary hyperparathyroidism (PHPT) are insulin resistant, and that surgical treatment may improve insulin sensitivity in this group of patients. The aim of our study was to evaluate the effect of surgical treatment on insulin sensitivity in patients with PHPT. Methods: In patients with PHPT (N=19; age: 58.15±8.38 years) insulin sensitivity was estimated using euglycemic hyperinsulinemic clamp (M value) before and 3 months after su...

It was shown that obesity and insulin resistance may influence ghrelin levels. Contraversial results were observed considering ghrelin levels in women with polycystic ovary syndrome (PCOS). The aim of our study was to investigate the basal ghrelin levels in obese patients with PCOS and to evaluate possible correlations between ghrelin levels, insulin resistance and, androgen levels. In 10 obese PCOS patients (BMI 32.50±1.57 kg/m2, age: 21.4±0.85 years) and...

Insulin resistance and/or hyperinsulinemia are risk factors for CVD. Plasma homocysteine is also important risk factor for the development of premature cardiovascular disease (CVD) in type 2 diabetes. The relationship between level of insulin and homocysteine in insulin resistant state is not clear. The aim of our study was to investigate whether plasma homocystein levels are changed by acute hyperinsulinemia and to associate the change of plasma homocysteine with the level of...

It is supposed a simillar dirnal change of TSH, free fatty acids (FFA) and leptin in humans. Hypothalamic-pituitary-thyroid axis (HPT) is suppressed during food deprivation while there is an elevation of FFA further influencing glucose metabolism. The aim of our study was to investigate whether leptin can act as a metabolic signal linking the adipose tissue metabolism and the HPT. We studied 13 women with polycystic ovary disease-PCOS (mean age: 26.6±1.83 years; BMI: 34...

Abstract: Glomerular hyperfiltration has been suggested as a possible mechanism linking obesity and chronic kidney disease, independently of classical risk factors such as diabetes. In terms of determining the creatinine clearance has numerous drawbacks, in clinical use are predictors of glomerular filtration rate (GFR) which show varying degrees of accuracy in obese patients. The aim of our study was to determine whether it is in our group of obese patients without type 2 dia...

Introduction: Multiple endocrine neoplasia syndrome type 1 (MEN1) associated thymic carcinoids (Th-NETs) are rare and have poor prognosis. Cushing syndrome (CS) caused by Th-NET in MEN1 syndrome is extremely rare.Case report: We report a case of a 55-year-old man with CS at presentation due to ectopic ACTH production in MEN1 syndrome. Thirty years ago, this patient had total gastric resection due to Zollinger-Ellison’s syndrome and extirpation of tw...

Introduction: Women with polycystic ovary syndrome (PCOS) are at increased risk of developing insulin resistance (IR) and T2DM. In this study, we attempted to detect IR parameters that could be the best predictor T2DM in PCOS comparing to controls.Description of methods/design: In 130 women with PCOS (BMI=29.7±0.66 kg/m2; age: 25.6±0.59 years) and 41 controls (age and BMI matched) (BMI=28.5±1.35 kg/m2; age: 26.5±...